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(Circulation. 1950;1:161.)
© 1950 American Heart Association, Inc.

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Some Effects of Digoxin upon the Heart and Circulation in Man

Digoxin in Chronic Cor Pulmonale

M. IRENÉ FERRER M.D.¹; RÉJANE M. HARVEY M.D.¹; RICHARD T. CATHCART M.D.¹; CHARLES A. WEBSTER M.D.¹; DICKINSON W. RICHARDS JR. M.D.¹; ANDRÉ COURNAND M.D.¹

¹ From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Cardio-Pulmonary Laboratory of the First Medical and Chest Services (Columbia University Division), Bellevue Hospital, New York, N. Y.

The effects of acute digitalization upon the dynamics of the circulation were observed in patients with chronic cor pulmonale, using the technic of cardiac catheterization. The state of the circulation was further investigated in the same patients following recovery from failure. The mode of action of intravenous digoxin is discussed, and a tentative concept of the pathogenesis of chronic cor pulmonale is presented.

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