1 From the Hypertension Division, Department of Internal Medicine, Washington University School of Medicine, The Oscar Johnson Institute, and Barnes Hospital, Saint Louis, Mo., under a grant-in-aid from the National Heart Institute, United States Public Health Service, and Ciba Pharmaceutical Products, Inc.
One hundred and six patients in malignant stages of hypertension were treated with continuous oral hexamethonium chloride and 1-hydrazinophthalazine. The courses of ten uremic individuals were unaffected. Twenty-eight discontinued therapy, three of whom survived two months. Sixty-eight nonuremic patients continued treatment and 54 are alive 15 to 36 months later; 17 who were azotemic have lived two to three years. Of the 14 who died, only three succumbed to hypertensive complications. Forty-six of the living patients have returned to full activity. Apparently the malignant stage of hypertension is reversible by drugs properly used to lower blood pressure and no longer need be the rapidly fatal disease that it has been in the past.
© 1954 American Heart Association, Inc.
Studies on the Control of Hypertension by Hyphex
V. Effects on the Course of the Malignant Stage
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