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Circulation. 1954;10:413-422

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(Circulation. 1954;10:413.)
© 1954 American Heart Association, Inc.

Postural Hypotension Induced by Atropine Sulfate

MARTIN H. KALSER M.D., PH.D.1; CHARLES W. FRYE M.S.1; ARCHER S. GORDON M.D., PH.D.1

1 From the Department of Clinical Science, University of Illinois College of Medicine, Chicago, Ill.

Previous tests on the use of large doses of atropine for the treatment of anticholinesterase poisoning have revealed postural hypotension following the administration of 2 mg. of this drug. In this study on 78 normal adult males, the cardiovascular responses to positional change after 2 mg. atropine have been measured and the mechanisms elucidated. Blood pressure response to tilting was normal during control and placebo phases, but showed a profound alteration after atropine.






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