(Circulation. 1999;100:2254.)
© 1999 American Heart Association, Inc.
Basic Science Reports |
Red Wine Inhibits Monocyte Chemotactic Protein-1 Expression and Modestly Reduces Neointimal Hyperplasia After Balloon Injury in Cholesterol-Fed Rabbits
From the Division of Cardiology (A.-N.F., Y.-T.C., S.-J.L.), Department of Medicine (Y.-Z.D.), Taipei Veterans General Hospital; Institute of Anatomy and Cell Biology (Y.-L.C.); Institute of Clinical Medicine (S.-J.L.); and the Cardiovascular Research Center (S.-J.L), National Yang-Ming University School of Medicine, Taipei, Taiwan.
Correspondence to Shing-Jong Lin, MD, PhD, Division of Cardiology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Rd, Taipei, Taiwan. E-mail sjlin{at}vghtpe.gov.tw
Background—Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte chemotactic protein-1 (MCP-1) expression were studied in cholesterol-fed rabbits.
Methods and Results—Male rabbits were fed a 2% cholesterol diet together with red wine (12.5% vol, 5 mL/kg body wt per day; n=7), white wine (13.3% vol, 5 mL/kg body wt per day; n=7), or no wine as a control (n=8) for 6 weeks. A balloon injury of the abdominal aorta was performed at the end of the third week. Abdominal aortas were harvested at the end of 6 weeks. Neointimal hyperplasia was measured morphometrically. MCP-1 expression was determined by Northern blot, in situ hybridization, and immunohistochemistry. Rabbits fed red wine had significantly less neointimal hyperplasia than did control rabbits (intima/media area ratio 0.59±0.05 [red wine group] versus 0.79±0.07 [control group], P<0.05). However, rabbits fed white wine showed a trend (but not significant) toward less intimal response compared with control rabbits (intima/media area ratio 0.65±0.04 [white wine group] versus 0.79±0.07 [control group], P=0.165). Both red wine and white wine significantly reduced MCP-1 mRNA and protein expression in the aorta.
Conclusions—Long-term consumption of red wine and white wine inhibits MCP-1 expression, and in the small number of animals studied, red wine modestly reduces neointimal hyperplasia. Since red wine exhibits higher antioxidant capacity than does white wine, the decreased intimal response might be partly attributed to its antioxidant effects.
Key Words: alcohol • vessels • restenosis • antioxidants • proteins
This article has been cited by other articles:
 |
|
 |
|
  P. Castilla, A. Davalos, J. L. Teruel, F. Cerrato, M. Fernandez-Lucas, J. L. Merino, C. C. Sanchez-Martin, J. Ortuno, and M. A Lasuncion Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vazquez-Agell, E. Sacanella, E. Tobias, M. Monagas, E. Antunez, R. Zamora-Ros, C. Andres-Lacueva, R. M. Lamuela-Raventos, J. Fernandez-Sola, J. M. Nicolas, et al. Inflammatory Markers of Atherosclerosis Are Decreased after Moderate Consumption of Cava (Sparkling Wine) in Men with Low Cardiovascular Risk J. Nutr., October 1, 2007; 137(10): 2279 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Castilla, R. Echarri, A. Davalos, F. Cerrato, H. Ortega, J. L. Teruel, M. F. Lucas, D. Gomez-Coronado, J. Ortuno, and M. A Lasuncion Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects Am. J. Clinical Nutrition, July 1, 2006; 84(1): 252 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Zern and M. L. Fernandez Cardioprotective Effects of Dietary Polyphenols J. Nutr., October 1, 2005; 135(10): 2291 - 2294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Cullen, S. Sayeed, Y. Jin, N. G. Theodorakis, J. V. Sitzmann, P. A. Cahill, and E. M. Redmond Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1669 - H1675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-H. Oak, J. El Bedoui, P. Anglard, and V. B. Schini-Kerth Red Wine Polyphenolic Compounds Strongly Inhibit Pro-Matrix Metalloproteinase-2 Expression and Its Activation in Response to Thrombin via Direct Inhibition of Membrane Type 1-Matrix Metalloproteinase in Vascular Smooth Muscle Cells Circulation, September 28, 2004; 110(13): 1861 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dell'Agli, A. Busciala, and E. Bosisio Vascular effects of wine polyphenols Cardiovasc Res, September 1, 2004; 63(4): 593 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Badia, E. Sacanella, J. Fernandez-Sola, J. M. Nicolas, E. Antunez, D. Rotilio, G. de Gaetano, A. Urbano-Marquez, and R. Estruch Decreased tumor necrosis factor-induced adhesion of human monocytes to endothelial cells after moderate alcohol consumption Am. J. Clinical Nutrition, July 1, 2004; 80(1): 225 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Colombo and G. Sangiorgi The monocyte: the key in the lock to reduce stent hyperplasia? J. Am. Coll. Cardiol., January 7, 2004; 43(1): 24 - 26. [Full Text] [PDF]
|
|
|
|
|
|
E. Waddington, I. B Puddey, and K. D Croft Red wine polyphenolic compounds inhibit atherosclerosis in apolipoprotein E-deficient mice independently of effects on lipid peroxidation Am. J. Clinical Nutrition, January 1, 2004; 79(1): 54 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-H. Oak, M. Chataigneau, T. Keravis, T. Chataigneau, A. Beretz, R. Andriantsitohaina, J.-C. Stoclet, S.-J. Chang, and V. B. Schini-Kerth Red Wine Polyphenolic Compounds Inhibit Vascular Endothelial Growth Factor Expression in Vascular Smooth Muscle Cells by Preventing the Activation of the p38 Mitogen-Activated Protein Kinase Pathway Arterioscler Thromb Vasc Biol, June 1, 2003; 23(6): 1001 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pellegatta, A. A. Bertelli, B. Staels, C. Duhem, A. Fulgenzi, and M. E. Ferrero Different short- and long-term effects of resveratrol on nuclear factor-{kappa}B phosphorylation and nuclear appearance in human endothelial cells Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1220 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Peters, S. Martini, R. Woydt, M. Ruckert, F. Shimizu, H. Kawachi, L. Liefeldt, S. Kramer, and H.-H. Neumayer Moderate alcohol intake has no impact on acute and chronic progressive anti-thy1 glomerulonephritis Am J Physiol Renal Physiol, May 1, 2003; 284(5): F1105 - F1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. de Lemos, D. A. Morrow, M. S. Sabatine, S. A. Murphy, C. M. Gibson, E. M. Antman, C. H. McCabe, C. P. Cannon, and E. Braunwald Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes Circulation, February 11, 2003; 107(5): 690 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. W. Lee, B. Hennig, and M. Toborek Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H185 - H192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pataki, I. Bak, P. Kovacs, D. Bagchi, D. K Das, and A. Tosaki Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts Am. J. Clinical Nutrition, May 1, 2002; 75(5): 894 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Horvath, F. G.P. Welt, M. Nedelman, P. Rao, and C. Rogers Targeting CCR2 or CD18 Inhibits Experimental In-Stent Restenosis in Primates: Inhibitory Potential Depends on Type of Injury and Leukocytes Targeted Circ. Res., March 8, 2002; 90(4): 488 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Diebolt, B. Bucher, and R. Andriantsitohaina Wine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression Hypertension, August 1, 2001; 38(2): 159 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Thibault, C. Lai, N. Wilke, B. Duong, M. F. Olive, S. Rahman, H. Dong, C. W. Hodge, D. J. Lockhart, and M. F. Miles Expression Profiling of Neural Cells Reveals Specific Patterns of Ethanol-Responsive Gene Expression Mol. Pharmacol., April 13, 2001; 58(6): 1593 - 1600. [Abstract] [Full Text]
|
|
|
|
|
|
L. M. Blanco-Colio, M. Valderrama, L. A. Alvarez-Sala, C. Bustos, M. Ortego, M. A. Hernandez-Presa, P. Cancelas, J. Gomez-Gerique, J. Millan, and J. Egido Red Wine Intake Prevents Nuclear Factor-{kappa}B Activation in Peripheral Blood Mononuclear Cells of Healthy Volunteers During Postprandial Lipemia Circulation, August 29, 2000; 102(9): 1020 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C.P. Azevedo, M. d. A. Pedro, L. C. Souza, H. P. de Souza, M. Janiszewski, P. L. da Luz, and F. R.M. Laurindo Oxidative stress as a signaling mechanism of the vascular response to injury: The redox hypothesis of restenosis Cardiovasc Res, August 18, 2000; 47(3): 436 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Horvath, F. G.P. Welt, M. Nedelman, P. Rao, and C. Rogers Targeting CCR2 or CD18 Inhibits Experimental In-Stent Restenosis in Primates: Inhibitory Potential Depends on Type of Injury and Leukocytes Targeted Circ. Res., March 8, 2002; 90(4): 488 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Froberg, A. Adams, N. Seacotte, J. Parker-Thornburg, and P. Kolattukudy Cytomegalovirus Infection Accelerates Inflammation in Vascular Tissue Overexpressing Monocyte Chemoattractant Protein-1 Circ. Res., December 7, 2001; 89(12): 1224 - 1230. [Abstract] [Full Text] [PDF]
|
|