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Circulation. 1999;100:789-792

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(Circulation. 1999;100:789-792.)
© 1999 American Heart Association, Inc.


Brief Rapid Communication

Late Coronary Occlusion After Intracoronary Brachytherapy

Marco A. Costa, MD; Manel Sabaté, MD; Wim J. van der Giessen, MD, PhD; I. Patrick Kay, MBChB; Pavel Cervinka, MD; Jurgen M. R. Ligthart, BSc; Pedro Serrano, MD; Veronique L. M. A. Coen, MD; Peter C. Levendag, MD, PhD; Patrick W. Serruys, MD, PhD

From Thoraxcenter (M.A.C., M.S., W.J.v.d.G., I.P.K., P.C., J.M.R.L., P.S., P.W.S.), Dijkzigt University Hospital, and Daniel den Hoek Cancer Center (V.L.M.A.C., P.C.L.), Rotterdam, The Netherlands.

Correspondence to Prof Patrick W. Serruys, Head of the Department of Interventional Cardiology, University Hospital Dijkzigt-Thoraxcenter Bd418, Dr. Molewaterplein,40–3015GD Rotterdam, The Netherlands. E-mail serruys{at}card.azr.nl

Background—Intracoronary brachytherapy appears to be a promising technology to prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim of the study was to determine the incidence of late (>1 month) thrombosis after PTCA and radiotherapy.

Methods and Results—From April 1997 to March 1999, we successfully treated 108 patients with PTCA followed by intracoronary ß-radiation. Ninety-one patients have completed at least 2 months of clinical follow-up. Of these patients, 6.6% (6 patients) presented with sudden thrombotic events confirmed by angiography 2 to 15 months after intervention (2 balloon angioplasty and 4 stent). Some factors (overlapping stents, unhealed dissection) may have triggered the thrombosis process, but the timing of the event is extremely unusual. Therefore, the effect of radiation on delaying the healing process and maintaining a thrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events.

Conclusions—Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology.


Key Words: thrombosis • angioplasty • radioisotopes




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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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[Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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Circulation, June 11, 2002; 105(23): 2699 - 2700.
[Full Text] [PDF]


Home page
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Circulation, June 11, 2002; 105(23): 2737 - 2740.
[Abstract] [Full Text] [PDF]


Home page
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Circulation, May 28, 2002; 105(21): 2465 - 2468.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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Home page
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Home page
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HeartHome page
R Mansfield, S Bown, and J McEwan
Photodynamic therapy: shedding light on restenosis
Heart, December 1, 2001; 86(6): 612 - 618.
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CirculationHome page
P. S. Teirstein and R. E. Kuntz
New Frontiers in Interventional Cardiology: Intravascular Radiation to Prevent Restenosis
Circulation, November 20, 2001; 104(21): 2620 - 2626.
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CirculationHome page
P. K. Coussement, H. de Leon, T. Ueno, M. Y. Salame, S. B. King III, N. A.F. Chronos, and K. A. Robinson
Intracoronary {beta}-Radiation Exacerbates Long-Term Neointima Formation in Balloon-Injured Pig Coronary Arteries
Circulation, November 13, 2001; 104(20): 2459 - 2464.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
R. Beyar and A. Roguin
The sirolimus coated stent: will the Achilles heel of interventional cardiology finally be cured?
Eur. Heart J., November 2, 2001; 22(22): 2054 - 2057.
[PDF]


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CirculationHome page
J. E. Sousa, M. A. Costa, A. C. Abizaid, B. J. Rensing, A. S. Abizaid, L. F. Tanajura, K. Kozuma, G. Van Langenhove, A. G.M.R. Sousa, R. Falotico, et al.
Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents: One-Year Angiographic and Intravascular Ultrasound Follow-Up
Circulation, October 23, 2001; 104(17): 2007 - 2011.
[Abstract] [Full Text] [PDF]


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HeartHome page
F Liistro and A Colombo
Late acute thrombosis after paclitaxel eluting stent implantation
Heart, September 1, 2001; 86(3): 262 - 264.
[Abstract] [Full Text] [PDF]


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RadiologyHome page
R. M. Wolfram, B. Pokrajac, R. Ahmadi, C. Fellner, M. Gyongyosi, M. Haumer, R. Bucek, R. Potter, and E. Minar
Endovascular Brachytherapy for Prophylaxis against Restenosis after Long-Segment Femoropopliteal Placement of Stents: Initial Results
Radiology, September 1, 2001; 220(3): 724 - 729.
[Abstract] [Full Text] [PDF]


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CirculationHome page
S. O. Marx and A. R. Marks
Bench to Bedside: The Development of Rapamycin and Its Application to Stent Restenosis
Circulation, August 21, 2001; 104(8): 852 - 855.
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CirculationHome page
G. Tepe, L. M. Dinkelborg, U. Brehme, P. Muschick, B. Noll, T. Dietrich, A. Greschniok, A. Baumbach, C. D. Claussen, and S. H. Duda
Prophylaxis of Restenosis With 186Re-Labeled Stents in a Rabbit Model
Circulation, August 6, 2001; 104(4): 480 - 485.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
G. Sianos, I. P. Kay, M. A. Costa, E. Regar, K. Kozuma, P. J. de Feyter, E. Boersma, C. Disco, and P. W. Serruys
Geographical miss during catheter-based intracoronary beta-radiation: incidence and implications in the BRIE study
J. Am. Coll. Cardiol., August 1, 2001; 38(2): 415 - 420.
[Abstract] [Full Text] [PDF]


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CirculationHome page
Y. Honda, E. Grube, L. M. de la Fuente, P. G. Yock, S. H. Stertzer, and P. J. Fitzgerald
Novel Drug-Delivery Stent: Intravascular Ultrasound Observations From the First Human Experience With the QP2-Eluting Polymer Stent System
Circulation, July 24, 2001; 104(4): 380 - 383.
[Abstract] [Full Text] [PDF]


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VASC ENDOVASCULAR SURGHome page
J. Ludemann, K.-L. Schulte, O. Hader, S. Brehme, H.-D. Volk, and W.-D. Docke
Leukocyte/Endothelium Activation and Interactions During Femoral Percutaneous Transluminal Angioplasty
Vascular and Endovascular Surgery, July 1, 2001; 35(4): 293 - 301.
[Abstract] [PDF]


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RadiologyHome page
P. Wexberg, M. Gottsauner-Wolf, I. Sulzbacher, P. Birner, A. Laggner, and D. Glogar
Fatal Late Coronary Thrombosis after Implantation of a Radioactive Stent: Postmortem Angiographic and Histologic Findings—Case Report
Radiology, July 1, 2001; 220(1): 142 - 144.
[Abstract] [Full Text] [PDF]


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CirculationHome page
A. W. Heldman, L. Cheng, G. M. Jenkins, P. F. Heller, D.-W. Kim, M. Ware Jr, C. Nater, R. H. Hruban, B. Rezai, B. S. Abella, et al.
Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis
Circulation, May 8, 2001; 103(18): 2289 - 2295.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
Z. Chen, K. W. Woodburn, C. Shi, D. C. Adelman, C. Rogers, and D. I. Simon
Photodynamic Therapy With Motexafin Lutetium Induces Redox-Sensitive Apoptosis of Vascular Cells
Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 759 - 764.
[Abstract] [Full Text] [PDF]


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CirculationHome page
G. L. Kaluza, A. E. Raizner, W. Mazur, D. G. Schulz, J. M. Buergler, L. F. Fajardo, F. O. Tio, and N. M. Ali
Long-Term Effects of Intracoronary {beta}-Radiation in Balloon- and Stent-Injured Porcine Coronary Arteries
Circulation, April 24, 2001; 103(16): 2108 - 2113.
[Abstract] [Full Text] [PDF]


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CirculationHome page
A. Farb, S. Shroff, M. John, W. Sweet, and R. Virmani
Late Arterial Responses (6 and 12 Months) After 32P {beta}-Emitting Stent Placement : Sustained Intimal Suppression With Incomplete Healing
Circulation, April 10, 2001; 103(14): 1912 - 1919.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
A.J Wardeh, A.H.M Knook, I.P Kay, M Sabate, V.L.M.A Coen, D.P Foley, J.N Hamburger, P.C Levendag, W.J van der Giessen, and P.W Serruys
Clinical and angiographical follow-up after implantation of a 6-12{micro}Ci radioactive stent in patients with coronary artery disease
Eur. Heart J., April 2, 2001; 22(8): 669 - 675.
[Abstract] [PDF]


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RadiologyHome page
S. O. Trerotola and L. A. Turmel-Rodrigues
Off the Beaten Path: Transbrachial Approach for Native Fistula Interventions
Radiology, March 1, 2001; 218(3): 617 - 619.
[Full Text]


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NEJMHome page
V. Verin, Y. Popowski, B. de Bruyne, D. Baumgart, W. Sauerwein, M. Lins, G. Kovacs, M. Thomas, F. Calman, C. Disco, et al.
Endoluminal Beta-Radiation Therapy for the Prevention of Coronary Restenosis after Balloon Angioplasty
N. Engl. J. Med., January 25, 2001; 344(4): 243 - 249.
[Abstract] [Full Text] [PDF]


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NEJMHome page
M. B. Leon, P. S. Teirstein, J. W. Moses, P. Tripuraneni, A. J. Lansky, S. Jani, S. C. Wong, D. Fish, S. Ellis, D. R. Holmes, et al.
Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
N. Engl. J. Med., January 25, 2001; 344(4): 250 - 256.
[Abstract] [Full Text] [PDF]


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CirculationHome page
J. E. Sousa, M. A. Costa, A. Abizaid, A. S. Abizaid, F. Feres, I. M. F. Pinto, A. C. Seixas, R. Staico, L. A. Mattos, A. G. M. R. Sousa, et al.
Lack of Neointimal Proliferation After Implantation of Sirolimus-Coated Stents in Human Coronary Arteries : A Quantitative Coronary Angiography and Three-Dimensional Intravascular Ultrasound Study
Circulation, January 16, 2001; 103(2): 192 - 195.
[Abstract] [Full Text] [PDF]


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Cardiovasc ResHome page
M. Wohlfrom, J. Kotzerke, J. Kamenz, M. Eble, B. Hess, J. Wohrle, S. N Reske, V. Hombach, H. Hanke, and M. Hoher
Endovascular irradiation with the liquid {beta}-emitter Rhenium-188 to reduce restenosis after experimental wall injury
Cardiovasc Res, January 1, 2001; 49(1): 169 - 176.
[Abstract] [Full Text] [PDF]


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CirculationHome page
C. Di Mario, J. W. Moses, T. J. Anderson, R. Bonan, T. Muramatsu, A. C. Jain, J. Suarez de Lezo, S. Y. Cho, M. Kern, I. T. Meredith, et al.
Randomized Comparison of Elective Stent Implantation and Coronary Balloon Angioplasty Guided by Online Quantitative Angiography and Intracoronary Doppler
Circulation, December 12, 2000; 102(24): 2938 - 2944.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
P.W. Serruys and S.G. Carlier
Brachytherapy in the Journal: European cardiologists have their own forum and should use it!
Eur. Heart J., December 2, 2000; 21(24): 1994 - 1996.
[PDF]


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J Am Coll CardiolHome page
D. E. Drachman, E. R. Edelman, P. Seifert, A. R. Groothuis, D. A. Bornstein, K. R. Kamath, M. Palasis, D. Yang, S. H. Nott, and C. Rogers
Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months
J. Am. Coll. Cardiol., December 1, 2000; 36(7): 2325 - 2332.
[Abstract] [Full Text] [PDF]


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CirculationHome page
P. S. Teirstein
Fulfilling the Promise of Percutaneous Angioplasty
Circulation, November 28, 2000; 102(22): 2674 - 2676.
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CirculationHome page
E. Minar, B. Pokrajac, T. Maca, R. Ahmadi, C. Fellner, M. Mittlbock, W. Seitz, R. Wolfram, and R. Potter
Endovascular Brachytherapy for Prophylaxis of Restenosis After Femoropopliteal Angioplasty : Results of a Prospective Randomized Study
Circulation, November 28, 2000; 102(22): 2694 - 2699.
[Abstract] [Full Text] [PDF]


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CirculationHome page
E. Minar, R. Wolfram, B. Pokrajac, M. A. Costa, M. Sabate, W. J. van der Giessen, I. P. Kay, P. Cervinka, J. M.R. Ligthart, P. Serrano, et al.
Endovascular Brachytherapy and Late Thrombotic Occlusion Response
Circulation, November 28, 2000; 102 (22): e175 - e176.
[Full Text] [PDF]


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Eur Heart JHome page
R. Hoffmann and G.S. Mintz
Coronary in-stent restenosis--predictors, treatment and prevention
Eur. Heart J., November 1, 2000; 21(21): 1739 - 1749.
[PDF]


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HeartHome page
K R KARSCH and A C NEWBY
Stent magic! The genie has escaped from the bottle
Heart, November 1, 2000; 84(5): 469 - 470.
[Full Text]


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J Am Coll CardiolHome page
Y. Cottin, M. Kollum, R. Chan, B. Bhargava, Y. Vodovotz, and R. Waksman
Vascular repair after balloon overstretch injury in porcine model effects of intracoronary radiation
J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1389 - 1395.
[Abstract] [Full Text] [PDF]


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CirculationHome page
A. E. Raizner, S. N. Oesterle, R. Waksman, P. W. Serruys, A. Colombo, Y.-L. Lim, A. C. Yeung, W. J. van der Giessen, L. Vandertie, J. K. Chiu, et al.
Inhibition of Restenosis With {beta}-Emitting Radiotherapy : Report of the Proliferation Reduction With Vascular Energy Trial (PREVENT)
Circulation, August 29, 2000; 102(9): 951 - 958.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
D. Meerkin, J.-C. Tardif, O. F. Bertrand, J. Vincent, F. Harel, and R. Bonan
The effects of intracoronary brachytherapy on the natural history of postangioplasty dissections
J. Am. Coll. Cardiol., July 1, 2000; 36(1): 59 - 64.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
R. Waksman, B. Bhargava, G. S. Mintz, R. Mehran, A. J. Lansky, L. F. Satler, A. D. Pichard, K. M. Kent, and M. B. Leon
Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis
J. Am. Coll. Cardiol., July 1, 2000; 36(1): 65 - 68.
[Abstract] [Full Text] [PDF]


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Cardiovasc ResHome page
J. H. Baron, A. H. Gershlick, K. Hogrefe, J. Armstrong, C. M. Holt, R. K. Aggarwal, M. Azrin, M. Ezekowitz, and D. P. de Bono
In vitro evaluation of c7E3-Fab (ReoProTM) eluting polymer-coated coronary stents
Cardiovasc Res, June 1, 2000; 46(3): 585 - 594.
[Abstract] [Full Text] [PDF]


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CirculationHome page
J. M. Ahmed, G. S. Mintz, R. Waksman, N. J. Weissman, R. Mehran, A. D. Pichard, L. F. Satler, K. M. Kent, and M. B. Leon
Safety of Intracoronary {gamma}-Radiation on Uninjured Reference Segments During the First 6 Months After Treatment of In-Stent Restenosis : A Serial Intravascular Ultrasound Study
Circulation, May 16, 2000; 101(19): 2227 - 2230.
[Abstract] [Full Text] [PDF]


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CirculationHome page
R. E. Kuntz and D. S. Baim
Prevention of Coronary Restenosis : The Evolving Evidence Base for Radiation Therapy
Circulation, May 9, 2000; 101(18): 2130 - 2133.
[Full Text] [PDF]


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CirculationHome page
R. Waksman, R. L. White, R. C. Chan, B. G. Bass, L. Geirlach, G. S. Mintz, L. F. Satler, R. Mehran, P. W. Serruys, A. J. Lansky, et al.
Intracoronary {gamma}-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis
Circulation, May 9, 2000; 101(18): 2165 - 2171.
[Abstract] [Full Text] [PDF]