(Circulation. 2000;101:122.)
© 2000 American Heart Association, Inc.
Brief Rapid Communications |
Carvedilol Inhibits Reactive Oxygen Species Generation by Leukocytes and Oxidative Damage to Amino Acids
From the Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY.
Correspondence to Paresh Dandona, MD, Director, Diabetes Endocrinology Center of Western New York, Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209. E-mail pdandona{at}kaleidahealth.org
Background—The purpose of this study was to test whether carvedilol has an antioxidant effect in humans in vivo.
Methods and Results—We administered 3.125 mg of carvedilol twice daily to normal subjects for 1 week. ROS generation by polymorphonuclear leukocytes and mononuclear cells fell from 314±183.43 and 303±116 mV to 185±157 and 189±63 mV (P<0.025), respectively. m-Tyrosine fell from 4.24±0.99 to 4.03±0.97 ng/mL (P=0.01), and o-tyrosine fell from 4.59±1.10 to 4.24±0.99 ng/mL (P=0.004) in the absence of a change in phenylalanine concentrations.
Conclusions—We conclude that carvedilol significantly inhibits ROS generation by leukocytes and oxidative conversion of phenylalanine to m- and o-tyrosine.
Key Words: carvedilol • oxygen • leukocytes • amino acids
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