(Circulation. 2000;101:2601.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Local Pulse Pressure and Regression of Arterial Wall Hypertrophy During Long-Term Antihypertensive Treatment
From the Department of Pharmacology and INSERM U 337 (P.B., C.B., B.L., S.L.), Broussais Hospital, Paris, France; Rhône-Poulenc-Rorer (N.D.), Paris, France; and Division of Hypertension and Vascular Medicine, CHUV (D.H., J.H., H.B.), Lausanne, Switzerland.
Background—Local pulse pressure (PP) is an independent determinant of carotid artery wall thickness, stronger than mean blood pressure (BP). The present study was designed to assess whether a ß-adrenoceptor antagonist–based or an ACE inhibitor–based treatment was able to reduce carotid artery wall hypertrophy through a reduction in carotid PP rather than by lowering mean BP and whether the influence of local PP reduction could also be detected at the site of a muscular artery, the radial artery.
Methods and Results—Ninety-eight essential hypertensive patients were randomized to 9 months of double-blind treatment with either celiprolol or enalapril. Arterial parameters were determined with high-resolution echo-tracking systems. PP was measured locally with applanation tonometry and independently of mean BP. After 9 months of treatment, mean BP, carotid PP, and intimal-medial thickness (IMT) decreased significantly, with no difference between the 2 groups. The reduction in carotid PP but not in mean BP was a major independent determinant of the reduction in carotid IMT. Radial artery IMT and PP decreased significantly with both treatments. However, the reduction in radial artery IMT was not related to the changes in radial artery PP.
Conclusions—The regression of carotid artery wall hypertrophy during long-term antihypertensive treatment was dependent on the reduction in local PP rather than on the lowering of mean BP. The effect of PP lowering on IMT reduction was observed at the site of an elastic artery but not at the site of a muscular artery.
Key Words: blood pressure • arteries • hypertrophy • arteriosclerosis • remodeling
This article has been cited by other articles:
 |
|
 |
|
  S. Laurent, M. Briet, and P. Boutouyrie Large and Small Artery Cross-Talk and Recent Morbidity-Mortality Trials in Hypertension Hypertension, August 1, 2009; 54(2): 388 - 392. [Full Text] [PDF]
|
|
|
|
|
|
A. P. Avolio, L. M. Van Bortel, P. Boutouyrie, J. R. Cockcroft, C. M. McEniery, A. D. Protogerou, M. J. Roman, M. E. Safar, P. Segers, and H. Smulyan Role of Pulse Pressure Amplification in Arterial Hypertension: Experts' Opinion and Review of the Data Hypertension, August 1, 2009; 54(2): 375 - 383. [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Heffernan, S. Y. Jae, K. R. Wilund, J. A. Woods, and B. Fernhall Racial differences in central blood pressure and vascular function in young men Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2380 - H2387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Lee, S. Choi, J.-H. Jung, and N. Lee Effects of Atrial Fibrillation on Arterial Stiffness in Patients With Hypertension Angiology, August 1, 2008; 59(4): 459 - 463. [Abstract] [PDF]
|
|
|
|
|
|
R. S. Vasan Pathogenesis of Elevated Peripheral Pulse Pressure: Some Reflections and Thinking Forward Hypertension, January 1, 2008; 51(1): 33 - 36. [Full Text] [PDF]
|
|
|
|
 |
|
 K. O. Stumpe, E. Agabiti-Rosei, T. Zielinski, D. Schremmer, J. Scholze, P. Laeis, P. Schwandt, and M. Ludwig Original Research: Carotid intima-media thickness and plaque volume changes following 2-year angiotensin II-receptor blockade. The Multicentre Olmesartan atherosclerosis Regression Evaluation (MORE) study Therapeutic Advances in Cardiovascular Disease, December 1, 2007; 1(2): 97 - 106. [Abstract] [PDF]
|
|
|
|
|
|
M. Briet, C. Collin, S. Laurent, A. Tan, M. Azizi, M. Agharazii, X. Jeunemaitre, F. Alhenc-Gelas, and P. Boutouyrie Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects Hypertension, November 1, 2007; 50(5): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heeneman, J. C. Sluimer, and M. J.A.P. Daemen Angiotensin-Converting Enzyme and Vascular Remodeling Circ. Res., August 31, 2007; 101(5): 441 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Agabiti-Rosei, G. Mancia, M. F. O'Rourke, M. J. Roman, M. E. Safar, H. Smulyan, J.-G. Wang, I. B. Wilkinson, B. Williams, and C. Vlachopoulos Central Blood Pressure Measurements and Antihypertensive Therapy: A Consensus Document Hypertension, July 1, 2007; 50(1): 154 - 160. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. O'Rourke and J. B. Seward Central Arterial Pressure and Arterial Pressure Pulse: New Views Entering the Second Century After Korotkov Mayo Clin. Proc., August 1, 2006; 81(8): 1057 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-G. Wang, J. A. Staessen, Y. Li, L. M. Van Bortel, T. Nawrot, R. Fagard, F. H. Messerli, and M. Safar Carotid Intima-Media Thickness and Antihypertensive Treatment: A Meta-Analysis of Randomized Controlled Trials Stroke, July 1, 2006; 37(7): 1933 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-I. Tropeano, P. Boutouyrie, B. Pannier, R. Joannides, E. Balkestein, S. Katsahian, B. Laloux, C. Thuillez, H. Struijker-Boudier, and S. Laurent Brachial Pressure-Independent Reduction in Carotid Stiffness After Long-Term Angiotensin-Converting Enzyme Inhibition in Diabetic Hypertensives Hypertension, July 1, 2006; 48(1): 80 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Paini, P. Boutouyrie, D. Calvet, A.-I. Tropeano, B. Laloux, and S. Laurent Carotid and Aortic Stiffness: Determinants of Discrepancies Hypertension, March 1, 2006; 47(3): 371 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Armentano, J. G. Barra, D. B. Santana, F. M. Pessana, S. Graf, D. Craiem, L. M. Brandani, H. P. Baglivo, and R. A. Sanchez Smart Damping Modulation of Carotid Wall Energetics in Human Hypertension: Effects of Angiotensin-Converting Enzyme Inhibition Hypertension, March 1, 2006; 47(3): 384 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Reneman, J. M. Meinders, and A. P.G. Hoeks Non-invasive ultrasound in arterial wall dynamics in humans: what have we learned and what remains to be solved Eur. Heart J., May 2, 2005; 26(10): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Nair, D. Waters, W. Rogers, G. J. Kowalchuk, T. D. Stuckey, and D. M. Herrington Pulse Pressure and Coronary Atherosclerosis Progression in Postmenopausal Women Hypertension, January 1, 2005; 45(1): 53 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Liu, K. Ylitalo, R. Salonen, J. T. Salonen, and M.-R. Taskinen Circulating Oxidized Low-Density Lipoprotein and Its Association With Carotid Intima-Media Thickness in Asymptomatic Members of Familial Combined Hyperlipidemia Families Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1492 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boutouyrie, D. P. Germain, J.-N. Fiessinger, B. Laloux, J. Perdu, and S. Laurent Increased Carotid Wall Stress in Vascular Ehlers-Danlos Syndrome Circulation, March 30, 2004; 109(12): 1530 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Simon, P. Boutouyrie, J.M. Simon, B. Laloux, C. Tournigand, A.I. Tropeano, S. Laurent, and P. Jaillon Influence of Tamoxifen on Carotid Intima-Media Thickness in Postmenopausal Women Circulation, December 3, 2002; 106(23): 2925 - 2929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Pini, M. C. Cavallini, F. Bencini, G. Silvestrini, E. Tonon, W. De Alfieri, N. Marchionni, M. Di Bari, R. B. Devereux, G. Masotti, et al. Cardiovascular remodeling is greater in isolated systolic hypertension than in diastolic hypertension in older adults: the Insufficienza Cardiaca negli Anziani Residenti (ICARE) a Dicomano Study J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1283 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Corpataux, E. Haesler, P. Silacci, H. B. Ris, and D. Hayoz Low-pressure environment and remodelling of the forearm vein in Brescia-Cimino haemodialysis access Nephrol. Dial. Transplant., June 1, 2002; 17(6): 1057 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Swan, J. Mathew, P. Sleight, E. Lonn, D. Johnstone, J. Pogue, Q. Yi, J. Bosch, B. Sussex, J. Probstfield, et al. A Pill for Every Ill * Response Circulation, April 9, 2002; 105 (14): e82 - e82. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dart and B. A. Kingwell Pulse pressure--a review of mechanisms and clinical relevance J. Am. Coll. Cardiol., March 15, 2001; 37(4): 975 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Nichols and D. G. Edwards Arterial Elastance and Wave Reflection Augmentation of Systolic Blood Pressure: Deleterious Effects and Implications for Therapy Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2001; 6(1): 5 - 21. [Abstract] [PDF]
|
|
|
|
|
|
P. Boutouyrie, R. Corvisier, M. Azizi, D. Lemoine, B. Laloux, M.-C. Hallouin, and S. Laurent Effects of acupuncture on radial artery hemodynamics: controlled trials in sensitized and naive subjects Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H628 - H633. [Abstract] [Full Text] [PDF]
|
|