(Circulation. 2000;101:862.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Influence of the Menstrual Cycle on Sympathetic Activity, Baroreflex Sensitivity, and Vascular Transduction in Young Women
From the Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn.
Correspondence to Christopher T. Minson, PhD, Anesthesia Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905. E-mail minson.christopher{at}mayo.edu
Background—Our goal was to test sympathetic and cardiovagal baroreflex sensitivity and the transduction of sympathetic traffic into vascular resistance during the early follicular (EF) and midluteal (ML) phases of the menstrual cycle.
Methods and Results—Sympathetic baroreflex sensitivity was assessed by lowering and raising blood pressure with intravenous bolus doses of sodium nitroprusside and phenylephrine. It was defined as the slope relating muscle sympathetic nerve activity (MSNA; determined by microneurography) and diastolic blood pressure. Cardiovagal baroreflex sensitivity was defined as the slope relating R-R interval and systolic blood pressure. Vascular transduction was evaluated during ischemic handgrip exercise and postexercise ischemia, and it was defined as the slope relating MSNA and calf vascular resistance (determined by plethysmography). Resting MSNA (EF, 1170±151 U/min; ML, 2252±251 U/min; P<0.001) and plasma norepinephrine levels (EF, 240±21 pg/mL; ML, 294±25 pg/mL; P=0.025) were significantly higher in the ML than in the EF phase. Furthermore, sympathetic baroreflex sensitivity was greater during the ML than the EF phase in every subject (MSNA/diastolic blood pressure slopes: EF, -4.15; FL, -5.42; P=0.005). No significant differences in cardiovagal baroreflex sensitivity or vascular transduction were observed.
Conclusions—The present study suggests that the hormonal fluctuations that occur during the normal menstrual cycle may alter sympathetic outflow but not the transduction of sympathetic activity into vascular resistance.
Key Words: estrogens • progesterone • blood pressure • vasculature • muscles
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G. Weitz, M. Elam, J. Born, H. L. Fehm, and C. Dodt Postmenopausal Estrogen Administration Suppresses Muscle Sympathetic Nerve Activity J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 344 - 348. [Abstract] [Full Text]
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J. M. Stewart and A. Weldon Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome J Appl Physiol, October 1, 2000; 89(4): 1505 - 1512. [Abstract] [Full Text] [PDF]
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C. A. Ray Effect of gender on vestibular sympathoexcitation Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1330 - R1333. [Abstract] [Full Text] [PDF]
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C. T. Minson, J. R. Halliwill, T. M. Young, and M. J. Joyner Sympathetic Activity and Baroreflex Sensitivity in Young Women Taking Oral Contraceptives Circulation, September 26, 2000; 102(13): 1473 - 1476. [Abstract] [Full Text] [PDF]
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T. J. Horton, E. K. Miller, D. Glueck, and K. Tench No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E752 - E762. [Abstract] [Full Text] [PDF]
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F. A Dinenno, J. H Eisenach, N. M Dietz, and M. J Joyner Post-junctional {alpha}-adrenoceptors and basal limb vascular tone in healthy men J. Physiol., May 1, 2002; 540(3): 1103 - 1110. [Abstract] [Full Text] [PDF]
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