(Circulation. 2000;102:1158.)
© 2000 American Heart Association, Inc.
Basic Science Reports |
Myocardial Strain by Doppler Echocardiography
Validation of a New Method to Quantify Regional Myocardial Function
From the Institute for Surgical Research and The Department of Cardiology, Rikshospitalet, University of Oslo, and the Norwegian University of Science and Technology, Trondheim (H.T., B.A.), Norway.
Correspondence to Otto A. Smiseth, Institute for Surgical Research, Rikshospitalet, The National Hospital, N-0027 Oslo, Norway. E-mail o.a.smiseth{at}rh.uio.no
Background—Myocardial strain is a measure of regional deformation, and by definition, negative strain means shortening and positive strain, elongation. This study investigates whether myocardial strain can be measured by Doppler echocardiography as the time integral of regional velocity gradients, using sonomicrometry as reference method.
Methods and Results—In 13 anesthetized dogs, myocardial longitudinal strain was measured on apical images as the time integral of regional Doppler velocity gradients. Ultrasonic segment-length crystals were placed near the left ventricular (LV) apex and near the base. Apical ischemia was induced by occluding the left anterior descending coronary artery (LAD), and preload was increased by saline. Percentage systolic strain by Doppler correlated well with strain by sonomicrometry (y=0.82x-1.79, r=0.92, P<0.01). During LAD occlusion, apical myocardium became dyskinetic, as indicated by positive strain values and negative Doppler velocities. At the LV base, myocardial strain by Doppler, strain by sonomicrometry, and velocity of shortening by sonomicrometry (dL/dt) were unchanged during apical ischemia. However, myocardial Doppler velocities at the base decreased from 4.2±0.7 (±SEM) to 2.7±0.4 cm/s (P<0.05), probably reflecting loss of motion caused by tethering to apical segments. Volume loading increased myocardial Doppler velocities from 2.2±0.3 to 4.1±0.8 cm/s (P<0.05) and Doppler-derived strain from -12±1% to -22±2% (P<0.05), whereas peak LV elastance remained unchanged.
Conclusions—Myocardial strain by Doppler echocardiography may represent a new, powerful method for quantifying regional myocardial function and is less influenced by tethering effects than Doppler tissue imaging. Like myocardial Doppler velocities, strain is markedly load-dependent.
Key Words: echocardiography • strain • ischemia • ultrasonics • contractility
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K. M. Modesto, S. Cauduro, A. Dispenzieri, B. Khandheria, M. Belohlavek, P. Lysyansky, Z. Friedman, M. Gertz, and T. P. Abraham Two-dimensional acoustic pattern derived strain parameters closely correlate with one-dimensional tissue Doppler derived strain measurements Eur J Echocardiogr, August 1, 2006; 7(4): 315 - 321. [Abstract] [Full Text] [PDF]
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V. R.S. Fernandes, J. F. Polak, T. Edvardsen, B. Carvalho, A. Gomes, D. A. Bluemke, K. Nasir, D. H. O'Leary, and J. A.C. Lima Subclinical Atherosclerosis and Incipient Regional Myocardial Dysfunction in Asymptomatic Individuals: The Multi-Ethnic Study of Atherosclerosis (MESA) J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2420 - 2428. [Abstract] [Full Text] [PDF]
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M. Nahrendorf, J. U. Streif, K.-H. Hiller, K. Hu, P. Nordbeck, O. Ritter, D. Sosnovik, L. Bauer, S. Neubauer, P. M. Jakob, et al. Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2516 - H2521. [Abstract] [Full Text] [PDF]
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D. Mele, G. Pasanisi, F. Capasso, A. De Simone, M.-A. Morales, D. Poggio, A. Capucci, G. Tabacchi, L. Sallusti, and R. Ferrari Left intraventricular myocardial deformation dyssynchrony identifies responders to cardiac resynchronization therapy in patients with heart failure Eur. Heart J., May 1, 2006; 27(9): 1070 - 1078. [Abstract] [Full Text] [PDF]
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H. Skulstad, S. Urheim, T. Edvardsen, K. Andersen, E. Lyseggen, T. Vartdal, H. Ihlen, and O. A. Smiseth Grading of Myocardial Dysfunction by Tissue Doppler Echocardiography: A Comparison Between Velocity, Displacement, and Strain Imaging in Acute Ischemia J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1672 - 1682. [Abstract] [Full Text] [PDF]
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T. H. Marwick Measurement of Strain and Strain Rate by Echocardiography: Ready for Prime Time? J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1313 - 1327. [Abstract] [Full Text] [PDF]
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K. Serri, P. Reant, M. Lafitte, M. Berhouet, V. Le Bouffos, R. Roudaut, and S. Lafitte Global and Regional Myocardial Function Quantification by Two-Dimensional Strain: Application in Hypertrophic Cardiomyopathy J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1175 - 1181. [Abstract] [Full Text] [PDF]
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B. H. Amundsen, T. Helle-Valle, T. Edvardsen, H. Torp, J. Crosby, E. Lyseggen, A. Stoylen, H. Ihlen, J. A.C. Lima, O. A. Smiseth, et al. Noninvasive Myocardial Strain Measurement by Speckle Tracking Echocardiography: Validation Against Sonomicrometry and Tagged Magnetic Resonance Imaging J. Am. Coll. Cardiol., February 21, 2006; 47(4): 789 - 793. [Abstract] [Full Text] [PDF]
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M. S. Suffoletto, K. Dohi, M. Cannesson, S. Saba, and J. Gorcsan III Novel Speckle-Tracking Radial Strain From Routine Black-and-White Echocardiographic Images to Quantify Dyssynchrony and Predict Response to Cardiac Resynchronization Therapy Circulation, February 21, 2006; 113(7): 960 - 968. [Abstract] [Full Text] [PDF]
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