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Circulation. 2000;102:2619-2628

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(Circulation. 2000;102:2619.)
© 2000 American Heart Association, Inc.


Clinical Investigation and Reports

Circumferential Radiofrequency Ablation of Pulmonary Vein Ostia

A New Anatomic Approach for Curing Atrial Fibrillation

Carlo Pappone, MD, PhD; Salvatore Rosanio, MD, PhD; Giuseppe Oreto, MD; Monica Tocchi, MD; Filippo Gugliotta, BS; Gabriele Vicedomini, MD; Adriano Salvati, MD; Cosimo Dicandia, MD; Patrizio Mazzone, MD; Vincenzo Santinelli, MD; Simone Gulletta, MD; Sergio Chierchia, MD

From the Department of Cardiology, San Raffaele University Hospital (C.P., S.R., M.T., F.G., G.V., A.S., C.D., P.M., V.S., S.G., S.C.), Milan, Italy, and University of Messina (G.O.), Messina, Italy.

Correspondence to Dr Carlo Pappone, San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy. E-mail carlo.pappone{at}hsr.it

Background—The pulmonary veins (PVs) and surrounding ostial areas frequently house focal triggers or reentrant circuits critical to the genesis of atrial fibrillation (AF). We developed an anatomic approach aimed at isolating each PV from the left atrium (LA) by circumferential radiofrequency (RF) lesions around their ostia.

Methods and Results—We selected 26 patients with resistant AF, either paroxysmal (n=14) or permanent (n=12). A nonfluoroscopic mapping system was used to generate 3D electroanatomic LA maps and deliver RF energy. Two maps were acquired during coronary sinus and right atrial pacing to validate the lateral and septal PV lesions, respectively. Patients were followed up closely for >=6 months. Procedures lasted 290±58 minutes, including 80±22 minutes for acquisition of all maps, and 118±16 RF pulses were deployed. Among 14 patients in AF at the beginning of the procedure, 64% had sinus rhythm restoration during ablation. PV isolation was demonstrated in 76% of 104 PVs treated by low peak-to-peak electrogram amplitude (0.08±0.02 mV) inside the circular line and by disparity in activation times (58±11 ms) across the lesion. After 9±3 months, 22 patients (85%) were AF-free, including 62% not taking and 23% taking antiarrhythmic drugs, with no difference (P=NS) between paroxysmal and permanent AF. No thromboembolic events or PV stenoses were observed by transesophageal echocardiography.

Conclusions—Radiofrequency PV isolation with electroanatomic guidance is safe and effective in either paroxysmal or permanent AF.


Key Words: fibrillation • catheter ablation • mapping




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V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al.
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
J. Am. Coll. Cardiol., August 15, 2006; 48(4): e149 - e246.
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CirculationHome page
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al.
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
Circulation, August 15, 2006; 114(7): e257 - e354.
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CirculationHome page
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al.
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
Circulation, August 15, 2006; 114(7): 700 - 752.
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Eur Heart JHome page
Authors/Task Force Members, V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, et al.
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
Eur. Heart J., August 2, 2006; 27(16): 1979 - 2030.
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EuropaceHome page
I. Deisenhofer, H. Estner, B. Zrenner, J. Schreieck, S. Weyerbrock, G. Hessling, K. Scharf, M. R. Karch, and C. Schmitt
Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: incidence, electrophysiological characteristics, and results of radiofrequency ablation.
Europace, August 1, 2006; 8(8): 573 - 582.
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Ann. Thorac. Surg.Home page
M. Jahangiri, G. Weir, K. Mandal, I. Savelieva, and J. Camm
Current strategies in the management of atrial fibrillation.
Ann. Thorac. Surg., July 1, 2006; 82(1): 357 - 364.
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Ann. Thorac. Surg.Home page
M. E.W. Hemels, Y. L. Gu, A. E. Tuinenburg, P. W. Boonstra, A. C.P. Wiesfeld, M. P. van den Berg, D. J. Van Veldhuisen, and I. C. Van Gelder
Favorable long-term outcome of maze surgery in patients with lone atrial fibrillation.
Ann. Thorac. Surg., May 1, 2006; 81(5): 1773 - 1779.
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J Am Coll CardiolHome page
C. Pappone, G. Vicedomini, F. Manguso, F. Gugliotta, P. Mazzone, S. Gulletta, N. Sora, S. Sala, A. Marzi, G. Augello, et al.
Robotic Magnetic Navigation for Atrial Fibrillation Ablation
J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1390 - 1400.
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Ann. Thorac. Surg.Home page
S. Forlani, R. De Paulis, L. G. Wolf, R. Greco, P. Polisca, M. Moscarelli, and L. Chiariello
Conversion to Sinus Rhythm by Ablation Improves Quality of Life in Patients Submitted to Mitral Valve Surgery
Ann. Thorac. Surg., March 1, 2006; 81(3): 863 - 867.
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Postgrad. Med. J.Home page
M C S Hall and D M Todd
Modern management of arrhythmias
Postgrad. Med. J., February 1, 2006; 82(964): 117 - 125.
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J Am Coll CardiolHome page
T. Dickfeld, R. Kato, M. Zviman, S. Lai, G. Meininger, A. C. Lardo, A. Roguin, D. Blumke, R. Berger, H. Calkins, et al.
Characterization of Radiofrequency Ablation Lesions With Gadolinium-Enhanced Cardiovascular Magnetic Resonance Imaging
J. Am. Coll. Cardiol., January 17, 2006; 47(2): 370 - 378.
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Br. J. Radiol.Home page
A de Roos, L J M Kroft, J J Bax, H J Lamb, and J Geleijns
Cardiac applications of multislice computed tomography
Br. J. Radiol., January 1, 2006; 79(937): 9 - 16.
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CirculationHome page
J. Sra, D. Krum, A. Malloy, M. Vass, B. Belanger, E. Soubelet, R. Vaillant, and M. Akhtar
Registration of Three-Dimensional Left Atrial Computed Tomographic Images With Projection Images Obtained Using Fluoroscopy
Circulation, December 13, 2005; 112(24): 3763 - 3768.
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Eur Heart JHome page
V. Essebag, F. Baldessin, M. R. Reynolds, S. McClennen, J. Shah, K. F. Kwaku, P. Zimetbaum, and M. E. Josephson
Non-inducibility post-pulmonary vein isolation achieving exit block predicts freedom from atrial fibrillation
Eur. Heart J., December 1, 2005; 26(23): 2550 - 2555.
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HeartHome page
F R Quinn and A C Rankin
Atrial fibrillation ablation in the real world
Heart, December 1, 2005; 91(12): 1507 - 1508.
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CirculationHome page
W. P. Beukema, A. Elvan, H. T. Sie, A. R. Ramdat Misier, and H. J.J. Wellens
Successful Radiofrequency Ablation in Patients With Previous Atrial Fibrillation Results in a Significant Decrease in Left Atrial Size
Circulation, October 4, 2005; 112(14): 2089 - 2095.
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CirculationHome page
B. J. Padanilam and E. N. Prystowsky
Should Ablation Be First-Line Therapy and for Whom: The Antagonist Position
Circulation, August 23, 2005; 112(8): 1223 - 1231.
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ChestHome page
J. Edelson, R. Shah, and D. Ost
A 45-Year-Old Man With Left Lung Hypoperfusion and Possible Pulmonary Embolism
Chest, August 1, 2005; 128(2): 1032 - 1036.
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