(Circulation. 2000;102:500.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Alcohol Consumption and Risk of Coronary Heart Disease by Diabetes Status
From the Division of Preventive Medicine (U.A.A., J.M.G., P.A.L., S.L., J.E.B., J.E.M.), Channing Laboratory (J.E.M.), and Cardiovascular Division (J.M.G.), Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass; the Department of Epidemiology (J.E.B., J.E.M.) and Department of Nutrition (S.L.), Harvard School of Public Health, Boston, Mass; and Massachusetts Veterans Epidemiology Research and Information Center (J.M.G.), Veterans Affairs Medical Center, Brockton/West Roxbury, Mass. Dr Hennekens is visiting Professor of Medicine, and Epidemiology and Public Health at the University of Miami School of Medicine.
Correspondence to Umed A. Ajani, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Ave E, Boston, MA 02215-1204. E-mail uajani{at}rics.bwh.harvard.edu
Background—An inverse association between moderate alcohol consumption and coronary heart disease (CHD) has been observed in several epidemiological studies. To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and without diabetes mellitus in a prospective cohort study.
Methods and Results—A total of 87 938 US physicians (2790 with diagnosed diabetes mellitus) who were invited to participate in the Physicians’ Health Study and were free of myocardial infarction, stroke, cancer, or liver disease at baseline were followed for an average of 5.5 years for death with CHD as the underlying cause. During 480 876 person-years of follow-up, 850 deaths caused by CHD were documented: 717 deaths among nondiabetic men and 133 deaths among diabetic men. Among men without diabetes at baseline, the relative risk estimates for those reporting rarely/never, monthly, weekly, and daily alcohol consumption were 1.00 (referent), 1.02, 0.82, and 0.61 (95% CI 0.49 to 0.78; P for trend <0.0001) after adjustment for age, aspirin use, smoking, physical activity, body mass index, and history of angina, hypertension, and high cholesterol. Among men with diabetes at baseline, the relative risk estimates were 1.00 (referent), 1.11, 0.67, and 0.42 (95% CI 0.23 to 0.77; P for trend=0.0019).
Conclusions—These results suggest that light to moderate alcohol consumption is associated with similar risk reductions in CHD among diabetic and nondiabetic men.
Key Words: alcohol • coronary disease • diabetes mellitus • risk factors
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