Circulation. 2001;104:1927-1932
doi: 10.1161/hc4101.097527
doi: 10.1161/hc4101.097527
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(Circulation. 2001;104:1927.)
© 2001 American Heart Association, Inc.
Clinical Investigation and Reports |
Progression of Aortic Valve Calcification
Association With Coronary Atherosclerosis and Cardiovascular Risk Factors
From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany.
Correspondence to Dr Karsten Pohle, Medizinische Klinik II, Universität Erlangen-Nürnberg, Östliche Stadtmauerstr. 29, D-91054 Erlangen, Germany. E-mail Falk-Karsten.Pohle{at}rzmail.uni-erlangen.de
Background— Recent studies demonstrated an influence of atherosclerotic risk factors on the progression of aortic valve stenosis. The extent of aortic valve calcification (AVC) was also found to be a strong predictor of stenosis progression. We investigated the influence of the LDL cholesterol level (LDL), other standard cardiovascular risk factors, and the extent of coronary calcification (CC) on the progression of AVC quantified by electron beam tomography (EBT).
Methods and Results— In 104 patients (64.7±8 years, 89 male) with an EBT scan positive for AVC, CC and AVC were quantified using a volumetric score. EBT was repeated at a mean interval of 15 months (10 to 36 months), and the progression of AVC and CC was determined. Patients were divided into 2 groups according to LDL: group 1, LDL
3.36 mmol/L (130 mg/dL), 57 patients; group 2, LDL>3.36 mmol/L (130 mg/dL), 47 patients. Mean values for CC were 546±932 mm3 in scan 1 and 665±1085 mm3 in scan 2 for AVC 324±796 mm3 and 404±1076 mm3, respectively. The mean progression of CC was 27±37% (group 1, 16±22%; group 2, 39±46%, P0.001) and of AVC was 25±38% (group 1, 9±22%; group 2, 43±44%, P0.001).
Conclusions— Quantification of AVC by EBT permits new insights into the progression of aortic valve sclerosis. We observed a strong influence of LDL cholesterol level on the progression of AVC and CC, suggesting that lipid-lowering therapy may decrease the progression of aortic valve calcification.
Key Words: imaging • heart diseases • lipids • risk factors • atherosclerosis
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|
|
 |
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|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
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|
|
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|
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|
|
|
|
|
|
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|
|
|
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|
|
|
|
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|
|
|
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|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A K Nightingale and J D Horowitz Aortic sclerosis: not an innocent murmur but a marker of increased cardiovascular risk Heart, November 1, 2005; 91(11): 1389 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
B. Wu, S. Elmariah, F. S. Kaplan, G. Cheng, and E. R. Mohler III Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts: Implications for End-Stage Valvular Heart Disease Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): 592 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y.-M. Wang, S. S.-Y. Ho, M. Wang, E. K.-H. Liu, S. Ho, P. K.-T. Li, S.-F. Lui, and J. E. Sanderson Cardiac Valvular Calcification as a Marker of Atherosclerosis and Arterial Calcification in End-stage Renal Disease Arch Intern Med, February 14, 2005; 165(3): 327 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Systolic murmur in an asymptomatic 70 year old man Heart, January 1, 2005; 91(1): 125 - 125. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 L. J. Schurgers, H. Aebert, C. Vermeer, B. Bultmann, and J. Janzen Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood, November 15, 2004; 104(10): 3231 - 3232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Folsom, G. W. Evans, J. J. Carr, A. E. Stillman, and Atherosclerosis Risk in Communities (ARIC) Study I Association of Traditional and Nontraditional Cardiovascular Risk Factors with Coronary Artery Calcification Angiology, November 1, 2004; 55(6): 613 - 623. [Abstract] [PDF]
|
|
|
|
 |
|
 G. M. Novaro Electron Beam Computed Tomography: The Latest "Stethoscope" for Calcific Aortic Valve Disease Mayo Clin. Proc., October 1, 2004; 79(10): 1239 - 1241. [PDF]
|
|
|
|
|
|
K. Pohle, M. Otte, R. Maffert, D. Ropers, M. Schmid, W. G. Daniel, and S. Achenbach Association of Cardiovascular Risk Factors to Aortic Valve Calcification as Quantified by Electron Beam Computed Tomography Mayo Clin. Proc., October 1, 2004; 79(10): 1242 - 1246. [Abstract] [PDF]
|
|
|
|
|
|
N. M. Rajamannan and C. M. Otto Targeted Therapy to Prevent Progression of Calcific Aortic Stenosis Circulation, September 7, 2004; 110(10): 1180 - 1182. [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Rubin and S. J. Silverberg Vascular Calcification and Osteoporosis--The Nature of the Nexus J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4243 - 4245. [Full Text] [PDF]
|
|
|
|
|
|
V. M. Miller, G. Rodgers, J. A. Charlesworth, B. Kirkland, S. R. Severson, T. E. Rasmussen, M. Yagubyan, J. C. Rodgers, F. R. Cockerill III, R. L. Folk, et al. Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1115 - H1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Messika-Zeitoun, M.-C. Aubry, D. Detaint, L. F. Bielak, P. A. Peyser, P. F. Sheedy, S. T. Turner, J. F. Breen, C. Scott, A. J. Tajik, et al. Evaluation and Clinical Implications of Aortic Valve Calcification Measured by Electron-Beam Computed Tomography Circulation, July 20, 2004; 110(3): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J. R Ortlepp, F. Schmitz, V. Mevissen, S. Weiss, J. Huster, R. Dronskowski, G. Langebartels, R. Autschbach, K. Zerres, C. Weber, et al. The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis Eur. Heart J., March 2, 2004; 25(6): 514 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Otto Why is aortic sclerosis associated with adverse clinical outcomes? J. Am. Coll. Cardiol., January 21, 2004; 43(2): 176 - 178. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
G J Morgan-Hughes, P E Owens, C A Roobottom, and A J Marshall Three dimensional volume quantification of aortic valve calcification using multislice computed tomography Heart, October 1, 2003; 89(10): 1191 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Demer and Y. Tintut Mineral Exploration: Search for the Mechanism of Vascular Calcification and Beyond: The 2003 Jeffrey M. Hoeg Award Lecture Arterioscler Thromb Vasc Biol, October 1, 2003; 23(10): 1739 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Pate, M. N. Tahir, R. T. Murphy, and J. B. Foley Anti-inflammatory Effects of Statins in Patients with Aortic Stenosis Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2003; 8(3): 201 - 206. [Abstract] [PDF]
|
|
|
|
|
|
J R Ortlepp, F Schmitz, T Bozoglu, P Hanrath, and R Hoffmann Cardiovascular risk factors in patients with aortic stenosis predict prevalence of coronary artery disease but not of aortic stenosis: an angiographic pair matched case-control study Heart, September 1, 2003; 89(9): 1019 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-L. Chan Is aortic stenosis a preventable disease? J. Am. Coll. Cardiol., August 20, 2003; 42(4): 593 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Alpert Aortic Stenosis: A New Face for an Old Disease Arch Intern Med, August 11, 2003; 163(15): 1769 - 1770. [Full Text] [PDF]
|
|
|
|
|
|
T. M. Bashore and T. J. Gardner Valvular heart disease J. Am. Coll. Cardiol., July 16, 2003; 42(2): 388 - 390. [Full Text] [PDF]
|
|
|
|
|
|
S Atar, D S Jeon, H Luo, and R J Siegel Mitral annular calcification: a marker of severe coronary artery disease in patients under 65 years old Heart, February 1, 2003; 89(2): 161 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y.-M. Wang, M. Wang, J. Woo, C. W.-K. Lam, P. K.-T. Li, S.-F. Lui, and J. E. Sanderson Cardiac Valve Calcification as an Important Predictor for All-Cause Mortality and Cardiovascular Mortality in Long-Term Peritoneal Dialysis Patients: A Prospective Study J. Am. Soc. Nephrol., January 1, 2003; 14(1): 159 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 L. L Demer Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids Int. J. Epidemiol., August 1, 2002; 31(4): 737 - 741. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|