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(Circulation. 2001;104:2886.)
© 2001 American Heart Association, Inc.

Clinical Investigation and Reports

C-Reactive Protein Elevation in Patients With Atrial Arrhythmias

Inflammatory Mechanisms and Persistence of Atrial Fibrillation

Mina K. Chung, MD; David O. Martin, MD, MPH; Dennis Sprecher, MD; Oussama Wazni, MD; Anne Kanderian, MD; Cynthia A. Carnes, PharmD, PhD; John A. Bauer, PhD; Patrick J. Tchou, MD; Mark J. Niebauer, MD; Andrea Natale, MD; David R. Van Wagoner, PhD

From the Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, Ohio (M.K.C., D.O.M., D.S., O.W., A.K., P.J.T., M.J.N., A.N., D.R.V.W.) and the College of Pharmacy and the Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio (J.A.B., C.A.C.).

Correspondence to Mina K. Chung, MD, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, F-15, Cleveland, OH 44195. E-mail chungm{at}ccf.org

Background— Atrial fibrillation (AF) may persist due to structural changes in the atria that are promoted by inflammation. C-reactive protein (CRP), a marker of systemic inflammation, predicts cardiovascular events and stroke, a common sequela of AF. We hypothesized that CRP is elevated in patients with atrial arrhythmias.

Methods and Results— Using a case-control study design, CRP in 131 patients with atrial arrhythmias was compared with CRP in 71 control patients. Among arrhythmia patients, 6 had frequent atrial ectopy or tachycardia, 86 had paroxysmal AF, 39 had persistent AF lasting >30 days, and 70 had lone arrhythmias. CRP was higher in arrhythmia than in control patients (median, 0.21 versus 0.096 mg/dL; P<0.001). Arrhythmia patients in AF within 24 hours before sampling had higher CRP than those in sinus rhythm (0.30 versus 0.15 mg/dL; P<0.001). CRP in controls was not different than in patients with atrial ectopy or tachycardia. Lone arrhythmia patients had a CRP of 0.21 mg/dL, which was not significantly lower than arrhythmia patients with structural heart disease (CRP, 0.23 mg/dL) but higher than controls (P=0.002). Persistent AF patients had a higher CRP (0.34 mg/dL) than paroxysmal AF patients (0.18 mg/dL; P=0.008); both groups had higher CRP levels than controls (P0.005).

Conclusions— CRP is elevated in AF patients. This study is the first to document elevated CRP in non-postoperative arrhythmia patients. These findings are reinforced by stepwise CRP elevation with higher AF burden. Although the cause of elevated CRP levels in AF patients remains unknown, elevated CRP may reflect an inflammatory state that promotes the persistence of AF.

Key Words: fibrillation • arrhythmia • inflammation • C-reactiveprotein

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				Y. Yin, D. Dalal, and J. Dong Anti-inflammatory effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: potential benefits for the prevention of atrial fibrillation: reply Eur. Heart J., October 1, 2006; 27(19): 2371 - 2371. [Full Text] [PDF]

				D. Amar, A. Goenka, H. Zhang, B. Park, and H. T. Thaler Leukocytosis and increased risk of atrial fibrillation after general thoracic surgery. Ann. Thorac. Surg., September 1, 2006; 82(3): 1057 - 1061. [Abstract] [Full Text] [PDF]

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				V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society J. Am. Coll. Cardiol., August 15, 2006; 48(4): e149 - e246. [Full Text] [PDF]

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				K. Rahimi, S. Watzlawek, H. Thiele, M.-A. Secknus, B.-F. Hayerizadeh, J. Niebauer, and G. Schuler Incidence, time course, and predictors of early malignant ventricular arrhythmias after non-ST-segment elevation myocardial infarction in patients with early invasive treatment Eur. Heart J., July 2, 2006; 27(14): 1706 - 1711. [Abstract] [Full Text] [PDF]

				C. W. Hogue Jr, C. A. Palin, R. Kailasam, J. S. Lawton, A. Nassief, V. G. Davila-Roman, B. Thomas, and R. Damiano C-reactive protein levels and atrial fibrillation after cardiac surgery in women. Ann. Thorac. Surg., July 1, 2006; 82(1): 97 - 102. [Abstract] [Full Text] [PDF]

				M. Rotter, P. Jais, M.-C. Vergnes, P. Nurden, Y. Takahashi, P. Sanders, T. Rostock, M. Hocini, F. Sacher, and M. Haissaguerre Decline in C-Reactive Protein After Successful Ablation of Long-Lasting Persistent Atrial Fibrillation J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1231 - 1233. [Full Text] [PDF]

				S. Kurl, J. A. Laukkanen, L. Niskanen, D. Laaksonen, J. Sivenius, K. Nyyssonen, and J. T. Salonen Metabolic Syndrome and the Risk of Stroke in Middle-Aged Men Stroke, March 1, 2006; 37(3): 806 - 811. [Abstract] [Full Text] [PDF]

				A. Shiroshita-Takeshita, B. J.J.M. Brundel, J. Lavoie, and S. Nattel Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs Cardiovasc Res, March 1, 2006; 69(4): 865 - 875. [Abstract] [Full Text] [PDF]

				L. Mascitelli and F. Pezzetta Anti-Inflammatory Action of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers J. Am. Coll. Cardiol., February 21, 2006; 47(4): 889 - 889. [Full Text] [PDF]

				K. Matsuura, H. Ogino, H. Matsuda, K. Minatoya, H. Sasaki, A. Kada, T. Yagihara, and S. Kitamura Prediction and Incidence of Atrial Fibrillation After Aortic Arch Repair Ann. Thorac. Surg., February 1, 2006; 81(2): 514 - 518. [Abstract] [Full Text] [PDF]

				C. J. Boos, R. A. Anderson, and G. Y.H. Lip Is atrial fibrillation an inflammatory disorder? Eur. Heart J., January 2, 2006; 27(2): 136 - 149. [Abstract] [Full Text] [PDF]

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				J. F. Malouf, R. Kanagala, F. O. Al Atawi, A. G. Rosales, D. E. Davison, N. S. Murali, T. S.M. Tsang, K. Chandrasekaran, N. M. Ammash, P. A. Friedman, et al. High Sensitivity C-Reactive Protein: A Novel Predictor for Recurrence of Atrial Fibrillation After Successful Cardioversion J. Am. Coll. Cardiol., October 4, 2005; 46(7): 1284 - 1287. [Abstract] [Full Text] [PDF]

				M. D.M. Engelmann and J. H. Svendsen Inflammation in the genesis and perpetuation of atrial fibrillation Eur. Heart J., October 2, 2005; 26(20): 2083 - 2092. [Abstract] [Full Text] [PDF]

				O Wazni, D O Martin, N F Marrouche, M Shaaraoui, M K Chung, S Almahameed, R A Schweikert, W I Saliba, and A Natale C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion Heart, October 1, 2005; 91(10): 1303 - 1305. [Abstract] [Full Text] [PDF]

				C. A.C. Abreu Filho, L. A.F. Lisboa, L. A.O. Dallan, G. S. Spina, M. Grinberg, M. Scanavacca, E. A. Sosa, J. A. F. Ramires, and S. A. Oliveira Effectiveness of the Maze Procedure Using Cooled-Tip Radiofrequency Ablation in Patients With Permanent Atrial Fibrillation and Rheumatic Mitral Valve Disease Circulation, August 30, 2005; 112(9_suppl): I-20 - I-25. [Abstract] [Full Text] [PDF]

				A S Montenero, N Mollichelli, F Zumbo, A Antonelli, A Dolci, M Barberis, C Sirolla, T Staine, L Fiocca, N Bruno, et al. Helicobacter pylori and atrial fibrillation: a possible pathogenic link Heart, July 1, 2005; 91(7): 960 - 961. [Full Text] [PDF]

				M. L. Fontes, J. P. Mathew, H. M. Rinder, D. Zelterman, B. R. Smith, C. S. Rinder, and the Multicenter Study of Perioperative Ischemia (M Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation Anesth. Analg., July 1, 2005; 101(1): 17 - 23. [Abstract] [Full Text] [PDF]

				Y. Ishii, R. B. Schuessler, S. L. Gaynor, K. Yamada, A. S. Fu, J. P. Boineau, and R. J. Damiano Jr Inflammation of Atrium After Cardiac Surgery Is Associated With Inhomogeneity of Atrial Conduction and Atrial Fibrillation Circulation, June 7, 2005; 111(22): 2881 - 2888. [Abstract] [Full Text] [PDF]

				M. Di Napoli, M. Schwaninger, R. Cappelli, E. Ceccarelli, G. Di Gianfilippo, C. Donati, H. C.A. Emsley, S. Forconi, S. J. Hopkins, L. Masotti, et al. Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members Stroke, June 1, 2005; 36(6): 1316 - 1329. [Abstract] [Full Text] [PDF]

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				A. D. Shaw, A. A. Vaporciyan, X. Wu, T. M. King, M. R. Spitz, J. B. Putnam, and B. F. Dickey Inflammatory Gene Polymorphisms Influence Risk of Postoperative Morbidity After Lung Resection Ann. Thorac. Surg., May 1, 2005; 79(5): 1704 - 1710. [Abstract] [Full Text] [PDF]

				B. J. Gersh, T. S.M. Tsang, M. E. Barnes, and J. B. Seward The changing epidemiology of non-valvular atrial fibrillation: the role of novel risk factors Eur. Heart J. Suppl., May 1, 2005; 7(suppl_C): C5 - C11. [Abstract] [Full Text] [PDF]

				T. J. Wang, H. Parise, L. M. Sullivan, R. B. D'Agostino Sr, D. Levy, P. A. Wolf, R. S. Vasan, and E. J. Benjamin Obesity and the Risk of New-Onset Atrial Fibrillation--Reply JAMA, April 27, 2005; 293(16): 1975 - 1975. [Full Text] [PDF]

				K. Mandal, E. Torsney, J. Poloniecki, A. J. Camm, Q. Xu, and M. Jahangiri Association of High Intracellular, But Not Serum, Heat Shock Protein 70 With Postoperative Atrial Fibrillation Ann. Thorac. Surg., March 1, 2005; 79(3): 865 - 871. [Abstract] [Full Text] [PDF]

				L. M. Biasucci CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Clinical Use of Inflammatory Markers in Patients With Cardiovascular Diseases: A Background Paper Circulation, December 21, 2004; 110(25): e560 - e567. [Abstract] [Full Text] [PDF]

				A. Shiroshita-Takeshita, G. Schram, J. Lavoie, and S. Nattel Effect of Simvastatin and Antioxidant Vitamins on Atrial Fibrillation Promotion by Atrial-Tachycardia Remodeling in Dogs Circulation, October 19, 2004; 110(16): 2313 - 2319. [Abstract] [Full Text] [PDF]

				Y. Ishii, M. J. Gleva, M. C. Gamache, R. B. Schuessler, J. P. Boineau, M. S. Bailey, and R. J. Damiano Jr Atrial Tachyarrhythmias After the Maze Procedure: Incidence and Prognosis Circulation, September 14, 2004; 110(11_suppl_1): II-164 - II-168. [Abstract] [Full Text] [PDF]

				C. S. Fox, R. S. Vasan, and E. J. Benjamin Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring--Reply JAMA, September 8, 2004; 292(10): 1175 - 1175. [Full Text] [PDF]

				A. S. Gami, G. Pressman, S. M. Caples, R. Kanagala, J. J. Gard, D. E. Davison, J. F. Malouf, N. M. Ammash, P. A. Friedman, and V. K. Somers Association of Atrial Fibrillation and Obstructive Sleep Apnea Circulation, July 27, 2004; 110(4): 364 - 367. [Abstract] [Full Text] [PDF]