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(Circulation. 2001;104:429.)
© 2001 American Heart Association, Inc.

Clinical Investigation and Reports

Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension

Xing-Guo Sun, MD; James E. Hansen, MD; Ronald J. Oudiz, MD; Karlman Wasserman, MD, PhD

From the Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif.

Correspondence to Karlman Wasserman, MD, PhD, Department of Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Box 405, Torrance, CA 90509-2910. E-mail kwasserm{at}ucla.edu

Background— Patients with primary pulmonary hypertension (PPH) have a pulmonary vasculopathy that leads to exercise intolerance due to dyspnea and fatigue. To better understand the basis of the exercise limitation in patients with PPH, cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York Heart Association (NYHA) symptom class, and resting pulmonary hemodynamics were studied.

Methods and Results— We retrospectively evaluated 53 PPH patients who had right heart catheterization and cycle ergometer CPET studies to maximum tolerance as part of their clinical workups. No adverse events occurred during CPET. Reductions in peak O₂ uptake (O₂), anaerobic threshold, peak O₂ pulse, rate of increase in O₂, and ventilatory efficiency were consistently found. NYHA class correlated well with the above parameters of aerobic function and ventilatory efficiency but less well with resting pulmonary hemodynamics.

Conclusions— Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class.

Key Words: oxygen • hypertension, pulmonary • ventilation • exercise • hemodynamics

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