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(Circulation. 2001;104:480.)
© 2001 American Heart Association, Inc.

Basic Science Reports

Prophylaxis of Restenosis With ¹⁸⁶Re-Labeled Stents in a Rabbit Model

Gunnar Tepe, MD; Ludger M. Dinkelborg, PhD; Ute Brehme, PhD; Peter Muschick, PhD; Bernhard Noll, PhD; Tobias Dietrich, MD; Annette Greschniok, MD; Andreas Baumbach, MD; Claus D. Claussen, MD; Stephan H. Duda, MD

From the Department of Diagnostic Radiology (G.T., T.D., C.D.C., S.H.D.), the Department of Occupational and Social Medicine (U.B.), and the Institute of Pathology (A.G.), University of Tübingen; the Research Laboratories of Schering AG, Berlin (L.M.D., P.M.); and the Forschungszentrum Rossendorf, Dresden (B.N.), Germany; and the Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK (A.B.).

Reprint requests to Gunnar Tepe, MD, Department of Diagnostic Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany. E-mail gunnar.tepe{at}med.uni-tuebingen.de

Background— Intraluminal ß-irradiation has been shown to decrease neointimal proliferation after angioplasty in experimental models. The purpose of this study was to test the technical feasibility and biological effects of ¹⁸⁶Re-labeled stents.

Methods and Results— Thirty-four New Zealand White rabbits were fed a 0.5% cholesterol diet before balloon angioplasty and insertion of Palmaz stents in the infrarenal aorta. The animals were killed 7 weeks after stent implantation. Two of 34 animals died prematurely (aortic leak, pneumonia). Control stents (n=7) were compared with ¹⁸⁶Re stents (2.6 MBq [n=6], 8.1 MBq [n=5], 16.0 MBq [n=6], and 25.3 MBq [n=8]). Stent application was successful in all cases. No thrombus occlusion was observed. After 7 weeks, neointima formation was 2.2±0.2 mm² in the control group. In the treatment groups, a dose-dependent neointima reduction was detectable (0.5±0.5 mm² [2.6 MBq], 0.4±0.4 mm² [8.1 MBq], and 0 mm² [16.0 MBq, 25.3 MBq]). No induction of neointimal formation was observed at the edges of the stents. Radiation resulted in delayed reendothelialization.

Conclusions— ¹⁸⁶Re stents were capable of reducing neointima formation in a dose-dependent fashion. ¹⁸⁶Re stents did not cause late thrombosis or neointimal induction at the stent margins in the observation period of 7 weeks.

Key Words: atherosclerosis • angioplasty • hypertension • restenosis • radioisotopes • stents

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