Circulation. 2002;105:1304-1310
Published online before print February 25, 2002, doi: 10.1161/hc1102.105730
Published online before print February 25, 2002, doi: 10.1161/hc1102.105730
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;105:1304.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Effects of Long-Term Biventricular Stimulation for Resynchronization on Echocardiographic Measures of Remodeling
From the Cardiomyopathy and Arrhythmia Research and Education Center, University of California, San Francisco, Calif.
Correspondence to Leslie A. Saxon, MD, 500 Parnassus Ave, MU East Box 1354, San Francisco, CA 94143-1354. E-mail saxon{at}medicine.ucsf.edu
Background— Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated.
Methods and Results— Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved.
Conclusions— Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.
Key Words: pacing • ventricles • remodeling
This article has been cited by other articles:
 |
|
 |
|
  D. H. Kwon, C. M. Halley, T. P. Carrigan, V. Zysek, Z. B. Popovic, R. Setser, P. Schoenhagen, R. C. Starling, S. D. Flamm, and M. Y. Desai Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study. J. Am. Coll. Cardiol. Img., January 1, 2009; 2(1): 34 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Sweeney and F. W. Prinzen Ventricular Pump Function and Pacing: Physiological and Clinical Integration Circ Arrhythm Electrophysiol, June 1, 2008; 1(2): 127 - 139. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ypenburg, P. Lancellotti, L. F. Tops, E. Boersma, G. B. Bleeker, E. R. Holman, J. D. Thomas, M. J. Schalij, L. A. Pierard, and J. J. Bax Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy Eur. Heart J., March 2, 2008; 29(6): 757 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Inage, T. Yoshida, T. Hiraki, M. Ohe, T. Takeuchi, Y. Nagamoto, Y. Fukuda, T. Gondo, and T. Imaizumi Chronic cardiac resynchronization therapy reverses cardiac remodelling and improves invasive haemodynamics of patients with severe heart failure on optimal medical treatment Europace, March 1, 2008; 10(3): 379 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T V Salukhe, K Dimopoulos, R Sutton, P Poole-Wilson, M Y Henein, M Morgan, J R Clague, and D P Francis Instantaneous effects of resynchronisation therapy on exercise performance in heart failure patients: the mechanistic role and predictive power of total isovolumic time Heart, January 1, 2008; 94(1): 59 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ypenburg, P. Lancellotti, L. F. Tops, G. B. Bleeker, E. R. Holman, L. A. Pierard, M. J. Schalij, and J. J. Bax Acute Effects of Initiation and Withdrawal of Cardiac Resynchronization Therapy on Papillary Muscle Dyssynchrony and Mitral Regurgitation J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2071 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Kass Highlighting the R in CRT Circulation, September 25, 2007; 116(13): 1434 - 1436. [Full Text] [PDF]
|
|
|
|
|
|
P. A. Gould, G. Kong, V. Kalff, S. J. Duffy, A. J. Taylor, M. J. Kelly, and D. M. Kaye Improvement in cardiac adrenergic function post biventricular pacing for heart failure Europace, September 1, 2007; 9(9): 751 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Valzania, F. Gadler, M. J. Eriksson, A. Olsson, G. Boriani, and F. Braunschweig Electromechanical effects of cardiac resynchronization therapy during rest and stress in patients with heart failure Eur J Heart Fail, June 1, 2007; 9(6-7): 644 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Rao, U. N. Kumar, J. Schafer, E. Viloria, D. De Lurgio, and E. Foster Reduced Ventricular Volumes and Improved Systolic Function With Cardiac Resynchronization Therapy: A Randomized Trial Comparing Simultaneous Biventricular Pacing, Sequential Biventricular Pacing, and Left Ventricular Pacing Circulation, April 24, 2007; 115(16): 2136 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lichodziejewska, K. Kurnicka, K. Grudzka, J. Malysz, M. Ciurzynski, and D. Liszewska-Pfejfer Chronic and Acute Effects of Smoking on Left and Right Ventricular Relaxation in Young Healthy Smokers Chest, April 1, 2007; 131(4): 1142 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Hauptman and H. N. Sabbah Reversal of ventricular remodeling: Important to establish and difficult to define Eur J Heart Fail, April 1, 2007; 9(4): 325 - 328. [Full Text] [PDF]
|
|
|
|
|
|
L. A. Saxon, M. R. Bristow, J. Boehmer, S. Krueger, D. A. Kass, T. De Marco, P. Carson, L. DiCarlo, A. M. Feldman, E. Galle, et al. Predictors of Sudden Cardiac Death and Appropriate Shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial Circulation, December 19, 2006; 114(25): 2766 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kubanek, I. Malek, J. Bytesnik, P. Fridl, L. Riedlbauchova, L. Karasova, V. Lanska, and J. Kautzner Decrease in plasma B-type natriuretic peptide early after initiation of cardiac resynchronization therapy predicts clinical improvement at 12 months Eur J Heart Fail, December 1, 2006; 8(8): 832 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Bristow Cardiac resynchronization therapy and adrenergic mechanisms Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2590 - H2591. [Full Text] [PDF]
|
|
|
|
|
|
J J Bax and D Poldermans Mitral regurgitation and left ventricular dyssynchrony: implications for treatment Heart, October 1, 2006; 92(10): 1363 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Saxon More is better with cardiac resynchronization therapy--but is it enough? Eur. Heart J., August 2, 2006; 27(16): 1891 - 1892. [Full Text] [PDF]
|
|
|
|
|
|
C. Ermis and D. G. Benditt Cardiac resynchronization pacing without defibrillator capability: is this a viable option? Europace, July 1, 2006; 8(7): 499 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhang, J. W.-H. Fung, A. Auricchio, J. Y.-S. Chan, L. C.C. Kum, L. W. Wu, and C.-M. Yu Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure Eur. Heart J., June 2, 2006; 27(12): 1423 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mannaerts Regression of left ventricular mass and wall thickness after cardiac resynchronization therapy: proof of pathophysiological concept Eur. Heart J., June 2, 2006; 27(12): 1392 - 1393. [Full Text] [PDF]
|
|
|
|
|
|
N. M. Hawkins, M. C. Petrie, M. R. MacDonald, K. J. Hogg, and J. J.V. McMurray Selecting patients for cardiac resynchronization therapy: electrical or mechanical dyssynchrony? Eur. Heart J., June 1, 2006; 27(11): 1270 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Donal, C. Leclercq, C. Linde, and J.-C. Daubert Effects of cardiac resynchronization therapy on disease progression in chronic heart failure Eur. Heart J., May 1, 2006; 27(9): 1018 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. St John Sutton, T. Plappert, K. E. Hilpisch, W. T. Abraham, D. L. Hayes, and E. Chinchoy Sustained Reverse Left Ventricular Structural Remodeling With Cardiac Resynchronization at One Year Is a Function of Etiology: Quantitative Doppler Echocardiographic Evidence From the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Circulation, January 17, 2006; 113(2): 266 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Brandt, C. Reiner, R. Arnold, J. Sperzel, H. F. Pitschner, and C. W. Hamm Contractile response and mitral regurgitation after temporary interruption of long-term cardiac resynchronization therapy Eur. Heart J., January 2, 2006; 27(2): 187 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Ellery, L Williams, and M Frenneaux Role of resynchronisation therapy and implantable cardioverter defibrillators in heart failure Postgrad. Med. J., January 1, 2006; 82(963): 16 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, T. Abraham, S. S. Barold, O. A. Breithardt, J. W.H. Fung, S. Garrigue, J. Gorcsan III, D. L. Hayes, D. A. Kass, J. Knuuti, et al. Cardiac Resynchronization Therapy: Part 2--Issues During and After Device Implantation and Unresolved Questions J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2168 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kashani and S. S. Barold Significance of QRS Complex Duration in Patients With Heart Failure J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2183 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Aranda Jr, G. W. Woo, R. S. Schofield, E. M. Handberg, J. A. Hill, A. B. Curtis, S. F. Sears, J. S. Goff, D. F. Pauly, and J. B. Conti Management of Heart Failure After Cardiac Resynchronization Therapy: Integrating Advanced Heart Failure Treatment With Optimal Device Function J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2193 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Waggoner, M. N. Faddis, M. J. Gleva, L. de las Fuentes, and V. G. Davila-Roman Improvements in Left Ventricular Diastolic Function After Cardiac Resynchronization Therapy Are Coupled to Response in Systolic Performance J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2244 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Feldman, G. de Lissovoy, M. R. Bristow, L. A. Saxon, T. De Marco, D. A. Kass, J. Boehmer, S. Singh, D. J. Whellan, P. Carson, et al. Cost Effectiveness of Cardiac Resynchronization Therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2311 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mann and M. R. Bristow Mechanisms and Models in Heart Failure: The Biomechanical Model and Beyond Circulation, May 31, 2005; 111(21): 2837 - 2849. [Full Text] [PDF]
|
|
|
|
|
|
M U Braun, T Rauwolf, T Zerm, M Schulze, A Schnabel, and R H Strasser Long term biventricular resynchronisation therapy in advanced heart failure: effect on neurohormones Heart, May 1, 2005; 91(5): 601 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Pitzalis, M. Iacoviello, R. Romito, P. Guida, E. De Tommasi, G. Luzzi, M. Anaclerio, C. Forleo, and P. Rizzon Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy J. Am. Coll. Cardiol., January 4, 2005; 45(1): 65 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A Bleasdale and M P Frenneaux Cardiac resynchronisation therapy: when the drugs don't work. Heart, December 1, 2004; 90(suppl_6): vi2 - vi4. [Full Text] [PDF]
|
|
|
|
|
|
P. Knaapen, L. M.C. van Campen, C. C. de Cock, M. J.W. Gotte, C. A. Visser, A. A. Lammertsma, and F. C. Visser Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve Circulation, August 10, 2004; 110(6): 646 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, G. Ansalone, O. A. Breithardt, G. Derumeaux, C. Leclercq, M. J. Schalij, P. Sogaard, M. St. John Sutton, and P. Nihoyannopoulos Echocardiographic evaluation of cardiac resynchronization therapy: ready for routine clinical use?: A critical appraisal J. Am. Coll. Cardiol., July 7, 2004; 44(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Puglisi, M. Lunati, A. G.M Marullo, S. Bianchi, M. Feccia, F. Sgreccia, I. Vicini, S. Valsecchi, F. Musumeci, and E. Vitali Limited thoracotomy as a second choice alternative to transvenous implant for cardiac resynchronisation therapy delivery Eur. Heart J., June 2, 2004; 25(12): 1063 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Bristow, L. A. Saxon, J. Boehmer, S. Krueger, D. A. Kass, T. De Marco, P. Carson, L. DiCarlo, D. DeMets, B. G. White, et al. Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure N. Engl. J. Med., May 20, 2004; 350(21): 2140 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Penicka, J. Bartunek, B. De Bruyne, M. Vanderheyden, M. Goethals, M. De Zutter, P. Brugada, and P. Geelen Improvement of Left Ventricular Function After Cardiac Resynchronization Therapy Is Predicted by Tissue Doppler Imaging Echocardiography Circulation, March 2, 2004; 109(8): 978 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Puggioni, M. Brignole, M. Gammage, E. Soldati, M. G. Bongiorni, E. N. Simantirakis, P. Vardas, F. Gadler, L. Bergfeldt, C. Tomasi, et al. Acute comparative effect of right and left ventricular pacing in patients with permanent atrial fibrillation J. Am. Coll. Cardiol., January 21, 2004; 43(2): 234 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Achilli, M. Sassara, S. Ficili, D. Pontillo, P. Achilli, C. Alessi, S. De Spirito, R. Guerra, N. Patruno, and F. Serra Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and "narrow" QRS J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2117 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Abraham and D. L. Hayes Cardiac Resynchronization Therapy for Heart Failure Circulation, November 25, 2003; 108(21): 2596 - 2603. [Full Text] [PDF]
|
|
|
|
|
|
L. Warner Stevenson The points for pacing J. Am. Coll. Cardiol., October 15, 2003; 42(8): 1460 - 1462. [Full Text] [PDF]
|
|
|
|
|
|
M. Jessup and S. Brozena Heart Failure N. Engl. J. Med., May 15, 2003; 348(20): 2007 - 2018. [Full Text] [PDF]
|
|
|
|
|
|
B. Nowak, A. M. Sinha, W. M. Schaefer, K.-C. Koch, H.-J. Kaiser, P. Hanrath, U. Buell, and C. Stellbrink Cardiac resynchronization therapyhomogenizes myocardial glucosemetabolism and perfusion in dilatedcardiomyopathy and left bundle branch block J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1523 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. St John Sutton, T. Plappert, W. T. Abraham, A. L. Smith, D. B. DeLurgio, A. R. Leon, E. Loh, D. Z. Kocovic, W. G. Fisher, M. Ellestad, et al. Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure Circulation, April 22, 2003; 107(15): 1985 - 1990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Breithardt, A. M. Sinha, E. Schwammenthal, N. Bidaoui, K. U. Markus, A. Franke, and C. Stellbrink Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure J. Am. Coll. Cardiol., March 5, 2003; 41(5): 765 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Bradley, E. A. Bradley, K. L. Baughman, R. D. Berger, H. Calkins, S. N. Goodman, D. A. Kass, and N. R. Powe Cardiac Resynchronization and Death From Progressive Heart Failure: A Meta-analysis of Randomized Controlled Trials JAMA, February 12, 2003; 289(6): 730 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ukkonen, R. S.B. Beanlands, I. G. Burwash, R. A. de Kemp, C. Nahmias, E. Fallen, M. R.S. Hill, and A. S.L. Tang Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism Circulation, January 7, 2003; 107(1): 28 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stellbrink and B. Nowak The importance of being synchronous: on the prognostic value of ventricular conduction delay in heart failure J. Am. Coll. Cardiol., December 4, 2002; 40(11): 2031 - 2033. [Full Text] [PDF]
|
|