Circulation. 2002;105:1453-1458
Published online before print March 18, 2002, doi: 10.1161/01.CIR.0000012350.99718.AD
Published online before print March 18, 2002, doi: 10.1161/01.CIR.0000012350.99718.AD
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(Circulation. 2002;105:1453.)
© 2002 American Heart Association, Inc.
Primary Prevention of Sudden Cardiac Death in Idiopathic Dilated Cardiomyopathy
The Cardiomyopathy Trial (CAT)
From the Department of Cardiology, St Georg Hospital, Hamburg, Germany (D.B., M.A., B.B., M.V., K.H.K.); the Department of Cardiology, University Hospital, Hannover, Germany (J.T.); the Department of Cardiology, Klinikum Ludwigshafen (K.S.); the Department of Cardiology and Angiology, University Hospital, Münster (M.B.); the Department of Mathematics and Data Processing in Medicine, University Hospital Eppendorf, Hamburg, Germany (J.B.); and the Department of Cardiology, Central Hospital, Bielefeld, Germany (F.G.).
Correspondence to Dr Karl Heinz Kuck, St Georg Hospital, Lohmühlenstr 5, D-20099 Hamburg, Germany. E-mail kuck{at}uke.uni-hamburg.de
Background— Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
Methods and Results— Patients with recent onset of DCM (
9 months) and an ejection fraction 30% were randomly assigned to the implantation of an implantable cardioverter-defibrillator (ICD) or control. The primary end point of the trial was all-cause mortality at 1 year of follow-up. The trial was terminated after the inclusion of 104 patients because the all-cause mortality rate at 1 year did not reach the expected 30% in the control group. In August 2000, the vital status of all patients was updated by contacting patients, relatives, or local registration offices. One hundred four patients were enrolled in the trial: Fifty were assigned to ICD therapy and 54 to the control group. Mean follow-up was 22.8±4.3 months, on the basis of investigators’ follow-up. After 1 year, 6 patients were dead (4 in the ICD group and 2 in the control group). No sudden death occurred during the first and second years of follow-up. In August 2000, after a mean follow-up of 5.5±2.2 years, 30 deaths had occurred (13 in the ICD group and 17 in the control group). Cumulative survival was not significantly different between the two groups (93% and 80% in the control group versus 92% and 86% in the ICD group after 2 and 4 years, respectively).
Conclusions— This trial did not provide evidence in favor of prophylactic ICD implantation in patients with DCM of recent onset and impaired left ventricular ejection fraction.
Key Words: cardiomyopathy • defibrillation • tachycardia • fibrillation • death, sudden
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
 |
|
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|
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|
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|
|
|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
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|
|
|
|
|
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|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
Additional Information JAMA, March 15, 2006; 295(11): E1 - E6. [Full Text] [PDF]
|
|
|
|
|
|
M. Christ, T. Klima, W. Grimm, H.-H. Mueller, and B. Maisch Prognostic significance of serum cholesterol levels in patients with idiopathic dilated cardiomyopathy Eur. Heart J., March 2, 2006; 27(6): 691 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Goldberger and R. Lampert Implantable Cardioverter-Defibrillators: Expanding Indications and Technologies JAMA, February 15, 2006; 295(7): 809 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Ellery, L Williams, and M Frenneaux Role of resynchronisation therapy and implantable cardioverter defibrillators in heart failure Postgrad. Med. J., January 1, 2006; 82(963): 16 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Singh, W. J. Hall, S. McNitt, H. Wang, J. P. Daubert, W. Zareba, J. N. Ruskin, A. J. Moss, and and the MADIT-II Investigators Factors Influencing Appropriate Firing of the Implanted Defibrillator for Ventricular Tachycardia/Fibrillation: Findings From the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II) J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1712 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A.M.J. Theuns, A. S. Thornton, A. P. J. Klootwijk, M. F. Scholten, P. J.M.J. Vantrimpont, A. H.M.M. Balk, and L. J. Jordaens Outcome in patients with an ICD incorporating cardiac resynchronisation therapy: Differences between primary and secondary prophylaxis Eur J Heart Fail, October 1, 2005; 7(6): 1027 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
A. E. Buxton, A. J. Moss, A. E. Buxton, and A. J. Moss Should everyone with an ejection fraction less than or equal to 30% receive an implantable cardioverter-defibrillator? Circulation, May 17, 2005; 111(19): 2537 - 2549. [Full Text] [PDF]
|
|
|
|
 |
|
 R. E Lane, M. R Cowie, and A. W C Chow Prediction and prevention of sudden cardiac death in heart failure Heart, May 1, 2005; 91(5): 674 - 680. [Full Text] [PDF]
|
|
|
|
|
|
L. Fauchier, J. Douglas, D. Babuty, P. Cosnay, and J. P. Fauchier QT dispersion in nonischemic dilated cardiomyopathy. A long-term evaluation Eur J Heart Fail, March 2, 2005; 7(2): 277 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Desai, J. C. Fang, W. H. Maisel, and K. L. Baughman Implantable Defibrillators for the Prevention of Mortality in Patients With Nonischemic Cardiomyopathy: A Meta-analysis of Randomized Controlled Trials JAMA, December 15, 2004; 292(23): 2874 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nanthakumar, A. E. Epstein, G. N. Kay, V. J. Plumb, and D. S. Lee Prophylactic implantable cardioverter-defibrillator therapy in patients with left ventricular systolic dysfunction: A pooled analysis of 10 primary prevention trials J. Am. Coll. Cardiol., December 7, 2004; 44(11): 2166 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G Katritsis and A.J. Camm Nonsustained ventricular tachycardia: where do we stand? Eur. Heart J., July 1, 2004; 25(13): 1093 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kadish, A. Dyer, J. P. Daubert, R. Quigg, N.A. M. Estes, K. P. Anderson, H. Calkins, D. Hoch, J. Goldberger, A. Shalaby, et al. Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy N. Engl. J. Med., May 20, 2004; 350(21): 2151 - 2158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Rogers and M. E. Cain Electromechanical Associations N. Engl. J. Med., May 20, 2004; 350(21): 2193 - 2195. [Full Text] [PDF]
|
|
|
|
|
|
C. Linde Implantable cardioverter-defibrillator treatment and resynchronisation in heart failure Heart, February 1, 2004; 90(2): 231 - 234. [Full Text] [PDF]
|
|
|
|
|
|
M. Zecchin, A. Di Lenarda, A. Proclemer, G. Faganello, D. Facchin, E. Petz, and G. Sinagra The role of implantable cardioverter defibrillator for primary vs secondary prevention of sudden death in patients with idiopathic dilated cardiomyopathy Europace, January 1, 2004; 6(5): 400 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Grimm, M. Christ, J. Bach, H.-H. Muller, and B. Maisch Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy: Results of the Marburg Cardiomyopathy Study Circulation, December 9, 2003; 108(23): 2883 - 2891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. DiMarco Implantable Cardioverter-Defibrillators N. Engl. J. Med., November 6, 2003; 349(19): 1836 - 1847. [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Antezano and M. Hong Sudden Cardiac Death J Intensive Care Med, November 1, 2003; 18(6): 313 - 329. [Abstract] [PDF]
|
|
|
|
|
|
G. Boriani, M. Biffi, C. Martignani, C. Camanini, F. Grigioni, C. Rapezzi, and A. Branzi Cardioverter-defibrillators after MADIT-II: the balance between weight of evidence and treatment costs Eur J Heart Fail, August 1, 2003; 5(4): 419 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Hohnloser, T. Klingenheben, D. Bloomfield, O. Dabbous, and R. J. Cohen Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2220 - 2224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Strickberger, J. D. Hummel, T. G. Bartlett, H. I. Frumin, C. D. Schuger, S. L. Beau, C. Bitar, F. Morady, and AMIOVIRT Investigators Amiodarone versus implantable cardioverter-defibrillator:randomized trial in patients with nonischemicdilated cardiomyopathy and asymptomaticnonsustained ventricular tachycardia--AMIOVIRT J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1707 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Jayachandran and D. P. Zipes Say no to primary prophylaxis with implantable cardioverter-defibrillators in asymptomatic nonischemic dilated cardiomyopathy? J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1713 - 1715. [Full Text] [PDF]
|
|
|
|
|
|
D. S. Lee, L. D. Green, P. P. Liu, P. Dorian, D. M. Newman, F. C. Grant, J. V. Tu, and D. A. Alter Effectiveness of implantable defibrillators for preventing arrhythmic events and death: A Meta-Analysis J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1573 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ezekowitz, P. W. Armstrong, and F. A. McAlister Implantable Cardioverter Defibrillators in Primary and Secondary Prevention: A Systematic Review of Randomized, Controlled Trials Ann Intern Med, March 18, 2003; 138(6): 445 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Stevenson and L. M. Epstein Predicting Sudden Death Risk for Heart Failure Patients in the Implantable Cardioverter-Defibrillator Age Circulation, February 4, 2003; 107(4): 514 - 516. [Full Text] [PDF]
|
|
|
|
|
|
M. Jessup The less familiar face of heart failure J. Am. Coll. Cardiol., January 15, 2003; 41(2): 224 - 226. [Full Text] [PDF]
|
|
|
|
|
|
S. G Priori, E. Aliot, C. Blomstrom-Lundqvist, L. Bossaert, G. Breithardt, P. Brugada, J. A Camm, R. Cappato, S. M Cobbe, C. Di Mario, et al. Update of the guidelines on sudden cardiac death of the European Society of Cardiology Eur. Heart J., January 1, 2003; 24(1): 13 - 15. [Full Text] [PDF]
|
|
|
|
|
|
D. J. van Veldhuisen and W. H. van Gilst The pharmacological management of heart failure: too many treatments? Eur J Heart Fail, January 1, 2003; 5(1): 5 - 8. [Full Text] [PDF]
|
|