Circulation. 2002;105:1548-1550
Published online before print March 18, 2002, doi: 10.1161/01.CIR.0000013847.07035.B9
Published online before print March 18, 2002, doi: 10.1161/01.CIR.0000013847.07035.B9
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(Circulation. 2002;105:1548.)
© 2002 American Heart Association, Inc.
Brief Rapid Communications |
Angiotensin-(1–7) Attenuates the Development of Heart Failure After Myocardial Infarction in Rats
From the Department of Clinical Pharmacology, University of Groningen (A.E.L., A.J.M.R., R.H.H., W.H.v.G.); Departments of Cardiology (R.A.T., W.H.v.G.) and Pathology (A.J.H.S.), University Hospital Groningen; and Department of Internal Medicine, Erasmus University Medical Center, Rotterdam (F.B.), the Netherlands.
Correspondence to A.E. Loot, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands. E-mail a.e.loot{at}med.rug.nl
Background— The renin-angiotensin system (RAS) is a key player in the progression of heart failure. Angiotensin-(1–7) is thought to modulate the activity of the RAS. Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the effects of angiotensin-(1–7) on the progression of heart failure.
Methods and Results— Male Sprague-Dawley rats underwent either coronary ligation or sham surgery. Two weeks after induction of myocardial infarction, intravenous infusion of angiotensin-(1–7) (24 µg/kg per hour) or saline was started by minipump. After 8 weeks of treatment, hemodynamic parameters were measured, endothelial function was assessed in isolated aortic rings, and plasma angiotensin-(1–7) levels were determined. Myocardial infarction resulted in a significant deterioration of left ventricular systolic and diastolic pressure, dP/dt, and coronary flow. Raising plasma levels 40-fold, angiotensin-(1–7) infusion attenuated this impairment to a nonsignificant level, markedly illustrated by a 40% reduction in left ventricular end-diastolic pressure. Furthermore, angiotensin-(1–7) completely preserved aortic endothelial function, whereas endothelium-dependent relaxation in aortas of saline-treated infarcted rats was significantly decreased.
Conclusions— Angiotensin-(1–7) preserved cardiac function, coronary perfusion, and aortic endothelial function in a rat model for heart failure.
Key Words: angiotensin • heart failure • hemodynamics • myocardial infarction
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|
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|
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|
|
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|
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|
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|
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|
|
|
|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
R. A. S. Santos, A. J. Ferreira, A. P. Nadu, A. N. G. Braga, A. P. de Almeida, M. J. Campagnole-Santos, O. Baltatu, R. Iliescu, T. L. Reudelhuber, and M. Bader Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats Physiol Genomics, May 19, 2004; 17(3): 292 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
R. M. Carey Angiotensin Type-1 Receptor Blockade Increases ACE 2 Expression in the Heart Hypertension, May 1, 2004; 43(5): 943 - 944. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schafer, D. Fraccarollo, P. Tas, I. Schmidt, G. Ertl, and J. Bauersachs Endothelial dysfunction in congestive heart failure: ACE inhibition vs. angiotensin II antagonism Eur J Heart Fail, March 1, 2004; 6(2): 151 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
D. B. Averill, Y. Ishiyama, M. C. Chappell, and C. M. Ferrario Cardiac Angiotensin-(1-7) in Ischemic Cardiomyopathy Circulation, October 28, 2003; 108(17): 2141 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. O. Sampaio, A. A. S. Nascimento, and R. A. S. Santos Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1985 - H1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stanton Review: Potential of renin inhibition in cardiovascular disease Journal of Renin-Angiotensin-Aldosterone System, March 1, 2003; 4(1): 6 - 10. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Campbell Vasopeptidase Inhibition: A Double-Edged Sword? Hypertension, March 1, 2003; 41(3): 383 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
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