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(Circulation. 2002;105:2493.)
© 2002 American Heart Association, Inc.

Clinical Investigation and Reports

Dosimetric Measurements in Isolated Human Coronary Arteries

Comparison of Commercially Available Iridium¹⁹² With Strontium/Yttrium⁹⁰ Emitters

Christoph Hanefeld, MD; Schgofa Amirie, MS; Dieter Borchardt, BSc; Peter Grewe, MD; K.-M. Müller, MD; Maria Kissler, MD; Andreas Mügge, MD

From the Cardiology Clinic (C.H., S.A., A.M.) and Radiation Oncology (D.B., M.K.) at St Josef Hospital, Ruhr University, Bochum, Germany, and the Department of Pathology (P.G., K.M.M.) at Bergmannsheil-Kliniken, Ruhr-University, Bochum, Germany.

Correspondence to Dr Andreas Mügge, Cardiology Clinic, St Josef Hospital, Ruhr University, Gudrunstrasse 56, 44791 Bochum, Germany. E-mail andreas.muegge{at}ruhr-uni-bochum.de

Background— Intravascular brachytherapy is being applied more and more in patients with coronary artery disease for the prevention of restenosis subsequent to balloon angioplasty, in particular after stent implantation. Several radiation sources (ß- and -emitters) are available in clinical routine. It was the purpose of this study to compare the radiation doses at the level of the adventitia in diseased and stented human coronary arteries for ¹⁹²Ir and ⁹⁰Sr/Y emitters in routine use. In contrast to previously published work, we performed dosimetry instead of calculating depth-dose distribution by use of the Monte Carlo system.

Methods and Results— Postmortem calcified human coronary artery segments were stented and placed in an organ bath. Commercially available -emitters (¹⁹²Ir; Cordis Checkmate) and ß-emitters (⁹⁰Sr/Y; Novoste Beta-Cath) were used. Relative dose distributions along the adventitia were measured by a specially designed scintillation detector system. Whereas dose perturbations caused by stents and calcified plaque were negligible for the ¹⁹²Ir source, radiation from the beta source was significantly impaired (as much as 40%) at the level of the adventitia (3.0-mm vessel diameter). Dose perturbation was clearly dependent on the extent and severity of calcification, less affected by stent material.

Conclusions— Dose perturbation caused by calcified plaque and metallic stents is significant for ß-sources. This dosimetric difference between ß- and -emitters in diseased coronary arteries should be considered when calculating doses in intravascular brachytherapy.

Key Words: angioplasty • restenosis • stenosis • stents • coronary disease

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