Published online before print January 22, 2002, doi: 10.1161/hc0702.104126
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(Circulation. 2002;105:800.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Risk of Myocardial Infarction and Angina in Patients With Severe Peripheral Vascular Disease
Predictive Role of C-Reactive Protein
From the Institute of Cardiology (E.R., L.M.B., S.P., C.M., F.G., D.J.A., G.L.) and Surgery (F.C., G.G.), Catholic University, Rome, Italy; and Department of Cardiovascular Disease (A.M.), University Vita-Salute, San Raffaele Hospital, Milano, Italy.
Correspondence to Elisabetta Rossi, Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Largo A.Gemelli 8, 00168 Roma, Italy. E-mail eliros{at}libero.it
Background— Patients undergoing revascularization procedures for peripheral vascular disease (PVD) have a greatly increased risk for coronary artery disease (CAD) that is predicted only partly by clinical data and cardiovascular risk factors. We investigated whether the prognostic assessment in PVD patients could be improved by preoperative measurements of C-reactive protein (CRP).
Methods and Results— We assessed clinical and risk factors profiles, Eagle clinical scores, and preoperative CRP serum levels in 51 patients with PVD at Fontaine-Leriche stages II to IV without severe rest ventricular dysfunction or ischemia. During 24 months of follow-up, 17 patients (34%) had fatal (11) or nonfatal (6) myocardial infarction (MI). With univariate logistic regression analysis, only previous history of CAD, Eagle score, and CRP were independently related to MI. At multivariate logistic regression analysis, only CRP values in the upper tertile (<9 mg/L) were significantly associated with MI (P<0.05) and identified 65% of cases.
Conclusions— The high incidence of MI in patients with PVD severe enough to require revascularization is strongly predicted by preprocedural measurements of serum CRP, independent of previous CAD, Eagle score index, and traditional cardiovascular risk factors. These patients may benefit from therapy modulating the inflammatory response.
Key Words: peripheral vascular disease • inflammation • prognosis
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