Published online before print September 3, 2002, doi: 10.1161/01.CIR.0000029745.63708.E9
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:1465.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Wine Drinking and Risks of Cardiovascular Complications After Recent Acute Myocardial Infarction
From the Laboratoire du Stress Cardiovasculaire et Pathologies Associées, Université Joseph Fourier de Grenoble, France (M.d.L., P.S., F.B., J.d.L.); Unité d’Epidémiologie de l’INRETS, Lyon, France (J.L.M.); and Département de Cardiologie, CHU-Hôpital Pontchaillou, Rennes, France (F.P.).
Correspondence to Dr M de Lorgeril, Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Médecine et Pharmacie, Domaine de la Merci, 38706 La Tronche (Grenoble), France. E-mail michel.delorgeril{at}ujf-grenoble.fr
Background— Scientific data on the clinical impact of moderate alcohol consumption after a recent acute myocardial infarction (AMI) are limited, and the specific effect of wine ethanol has not been studied.
Methods and Results— In survivors of a recent AMI, we analyzed the association between ethanol intake and the risk of recurrence. The patients were classified according to the amount of ethanol that they consumed regularly during follow-up. Major prognostic factors, including the severity of the prior AMI and drug treatment, were recorded and included in the analyses. Only patients with at least 2 reliable assessments of drinking (and dietary) habits were included (n=437). The average ethanol intake was 7.6% of the total energy intake, wherein wine ethanol represented 92% of the total. Among these patients, 104 cardiovascular complications occurred during a mean follow-up period of 4 years. In comparison with abstainers, the adjusted risk of complications was reduced by 59% (95% confidence interval: 17 to 80) in patients whose average ethanol intake was 7.7% of the total energy intake (about 2 drinks/day), and by 52% (95% confidence interval: 4 to 76) in those whose average ethanol intake was of 16% of energy (about 4 drinks/day).
Conclusion— Whereas moderate wine drinking was associated with a significant reduction in the risk of complications in this homogenous population of coronary heart disease patients, further studies are required to confirm the data, define the clinical and biological profile of the patients who would most benefit from wine drinking after recent AMI, and examine whether the relations found are due to ethanol or other wine ingredients.
Key Words: alcohol • coronary disease • myocardial infarction • prevention • diet
This article has been cited by other articles:
 |
|
 |
|
  R. di Giuseppe, M. de Lorgeril, P. Salen, F. Laporte, A. Di Castelnuovo, V. Krogh, A. Siani, J. Arnout, F. P Cappuccio, M. van Dongen, et al. Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations Am. J. Clinical Nutrition, January 1, 2009; 89(1): 354 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Corder Red wine, chocolate and vascular health: developing the evidence base Heart, July 1, 2008; 94(7): 821 - 823. [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Lorgeril, P. Salen, T. Corcos, P. Defaye, M. Juneau, B. Pavy, and N. Saoudi Is moderate drinking as effective as cholesterol lowering in reducing mortality in high-risk coronary patients? Eur. Heart J., January 1, 2008; 29(1): 4 - 6. [Full Text] [PDF]
|
|
|
|
|
|
I. Janszky, R. Ljung, S. Ahnve, J. Hallqvist, A. M. Bennet, and K. J. Mukamal Alcohol and long-term prognosis after a first acute myocardial infarction: the SHEEP study Eur. Heart J., January 1, 2008; 29(1): 45 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Ignarro, M. L. Balestrieri, and C. Napoli Nutrition, physical activity, and cardiovascular disease: An update Cardiovasc Res, January 15, 2007; 73(2): 326 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Mukamal, S. E. Chiuve, and E. B. Rimm Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med, October 23, 2006; 166(19): 2145 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. de Leiris, M. de Lorgeril, and F. Boucher Ethanol and cardiac function Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1027 - H1028. [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Mukamal, M. Maclure, J. E. Muller, and M. A. Mittleman Binge Drinking and Mortality After Acute Myocardial Infarction Circulation, December 20, 2005; 112(25): 3839 - 3845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Szmitko and S. Verma Antiatherogenic potential of red wine: clinician update Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2023 - H2030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Anstadt Modifiable Behavioral Factors as Causes of Death JAMA, June 23, 2004; 291(24): 2941 - 2941. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Aguilar, H. Skali, L. A. Moye, E. F. Lewis, J. M. Gaziano, J. D. Rutherford, L. H. Hartley, O. S. Randall, E. M. Geltman, G. A. Lamas, et al. Alcohol consumption and prognosis in patients with left ventricular systolic dysfunction after a myocardial infarction J. Am. Coll. Cardiol., June 2, 2004; 43(11): 2015 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M de Lorgeril and P Salen Is alcohol anti-inflammatory in the context of coronary heart disease? Heart, April 1, 2004; 90(4): 355 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M N Zairis, J A Ambrose, A G Lyras, M A Thoma, P K Psarogianni, P G Psaltiras, A D Kardoulas, G P Bibis, E G Pissimissis, P C Batika, et al. C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study Heart, April 1, 2004; 90(4): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bohm, S. Rosenkranz, and U. Laufs Alcohol and red wine: impact on cardiovascular risk Nephrol. Dial. Transplant., January 1, 2004; 19(1): 11 - 16. [Full Text] [PDF]
|
|