Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation. 2002;106:1760-1763
Published online before print September 23, 2002, doi: 10.1161/01.CIR.0000035037.11968.5C
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
106/14/1760    most recent
01.CIR.0000035037.11968.5Cv1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leclercq, C.
Right arrow Articles by Kass, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leclercq, C.
Right arrow Articles by Kass, D. A.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Cardiomyopathy
Related Collections
Right arrow Congestive
Right arrow Pacemaker
Right arrow Animal models of human disease
Right arrow Heart failure - basic studies
Right arrow Electrocardiology
Right arrow Computerized tomography and Magnetic Resonance Imaging

(Circulation. 2002;106:1760.)
© 2002 American Heart Association, Inc.

Brief Rapid Communications

Systolic Improvement and Mechanical Resynchronization Does Not Require Electrical Synchrony in the Dilated Failing Heart With Left Bundle-Branch Block

Christophe Leclercq, MD*; Owen Faris, BA*; Richard Tunin, MS; Jennifer Johnson, RN; Ritsuchi Kato, MD, PhD; Frank Evans, PhD; Julio Spinelli, PhD; Henry Halperin, MD; Elliot McVeigh, PhD; David A. Kass, MD

From the Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Md (C.L., R.T., J.J., R.K., H.H., D.A.K.); National Heart, Lung and Blood Institute/Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Md (O.F., F.E., E.M.); and Cardiac Pacemakers/Guidant, St Paul, Minneapolis, Minn (J.S.).

Correspondence to David A. Kass, Halsted 500, Johns Hopkins Hospital, 600 N. Wolfe St, Baltimore, MD 21287. E-mail dkass{at}jhmi.edu

Background— Biventricular (BiV) and left ventricular (LV) pacing similarly augment systolic function in left bundle-branch block (LBBB)-failing hearts despite different electrical activation. We tested whether electrical synchrony is required to achieve mechanical synchronization and functional benefit from pacing.

Methods and Results— Epicardial mapping, tagged MRI, and hemodynamics were obtained in dogs with LBBB-failing hearts during right atrial, LV, and BiV stimulation. BiV and LV both significantly improved chamber hemodynamics (eg, 25% increase in dP/dtmax and aortic pulse pressure) compared with atrial pacing-LBBB, and this improvement correlated with mechanical resynchronization. Electrical dispersion, however, decreased 13% with BiV but increased 23% with LV pacing (P<0.01).

Conclusion— Improved mechanical synchrony and function do not require electrical synchrony. Mechanical coordination plays the dominant role in global systolic improvement with either pacing approach.


Key Words: heart failure • pacing • electrical stimulation • bundle-branch block • ventricles




This article has been cited by other articles:


Home page
 EuropaceHome page
H. R. Bonakdar, M. V. Jorat, A. F. Fazelifar, A. Alizadeh, N. Givtaj, N. Sameie, A. Sadeghpour, and M. Haghjoo
Prediction of response to cardiac resynchronization therapy using simple electrocardiographic and echocardiographic tools
Europace, October 1, 2009; 11(10): 1330 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. K. Rutz, R. Manka, S. Kozerke, S. Roas, P. Boesiger, and J. Schwitter
Left ventricular dyssynchrony in patients with left bundle branch block and patients after myocardial infarction: integration of mechanics and viability by cardiac magnetic resonance
Eur. Heart J., September 1, 2009; 30(17): 2117 - 2127.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
B. W.L. De Boeck, A. J. Teske, M. Meine, G. E. Leenders, M. J. Cramer, F. W. Prinzen, and P. A. Doevendans
Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response
Eur J Heart Fail, September 1, 2009; 11(9): 863 - 871.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc GenetHome page
A. S. Barth, T. Aiba, V. Halperin, D. DiSilvestre, K. Chakir, C. Colantuoni, R. S. Tunin, V. L. Dimaano, W. Yu, T. P. Abraham, et al.
Cardiac Resynchronization Therapy Corrects Dyssynchrony-Induced Regional Gene Expression Changes on a Genomic Level
Circ Cardiovasc Genet, August 1, 2009; 2(4): 371 - 378.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
S. J. Buss, P. M. Humpert, R. Bekeredjian, S. E. Hardt, C. Zugck, D. Schellberg, A. Bauer, A. Filusch, H. Kuecherer, H. A. Katus, et al.
Echocardiographic phase imaging to predict reverse remodeling after cardiac resynchronization therapy.
J. Am. Coll. Cardiol. Img., May 1, 2009; 2(5): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
T. Abraham, D. Kass, G. Tonti, G. F. Tomassoni, W. T. Abraham, J. J. Bax, and T. H. Marwick
Imaging Cardiac Resynchronization Therapy
J. Am. Coll. Cardiol. Img., April 1, 2009; 2(4): 486 - 497.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Aiba, G. G. Hesketh, A. S. Barth, T. Liu, S. Daya, K. Chakir, V. L. Dimaano, T. P. Abraham, B. O'Rourke, F. G. Akar, et al.
Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy
Circulation, March 10, 2009; 119(9): 1220 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
C. Marcucci, R. Lauer, and A. Mahajan
New Echocardiographic Techniques for Evaluating Left Ventricular Myocardial Function
Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2008; 12(4): 228 - 247.
[Abstract] [PDF]

Home page
 JNMHome page
S. D. Van Kriekinge, H. Nishina, M. Ohba, D. S. Berman, and G. Germano
Automatic Global and Regional Phase Analysis from Gated Myocardial Perfusion SPECT Imaging: Application to the Characterization of Ventricular Contraction in Patients with Left Bundle Branch Block
J. Nucl. Med., November 1, 2008; 49(11): 1790 - 1797.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
E. Donal, C. de Chillou, I. Magnin-Poull, and C. Leclercq
Imaging in cardiac resynchronization therapy: what does the clinician need?
Europace, November 1, 2008; 10(suppl_3): iii70 - iii72.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
J. Chen, J. J. Bax, M. M. Henneman, M. J. Boogers, and E. V. Garcia
Is nuclear imaging a viable alternative technique to assess dyssynchrony?
Europace, November 1, 2008; 10(suppl_3): iii101 - iii105.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
J. Kautzner and P. Peichl
Selecting CRT candidates: the value of intracardiac mapping
Europace, November 1, 2008; 10(suppl_3): iii106 - iii109.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
K. C. Bilchick, V. Dimaano, K. C. Wu, R. H. Helm, R. G. Weiss, J. A. Lima, R. D. Berger, G. F. Tomaselli, D. A. Bluemke, H. R. Halperin, et al.
Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy.
J. Am. Coll. Cardiol. Img., September 1, 2008; 1(5): 561 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
B. L. Zaret
Cardiac imaging and cardiac resynchronization therapy: time to get in phase.
J. Am. Coll. Cardiol. Img., September 1, 2008; 1(5): 614 - 616.
[Full Text] [PDF]

Home page
 EuropaceHome page
S. H. Lim, G. Y.H. Lip, and J. E. Sanderson
Ventricular optimization of biventricular pacing: a systematic review
Europace, August 1, 2008; 10(8): 901 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
M. K. Friedberg, S. L. Roche, A. F. Mohammed, M. Balasingam, E. G. Atenafu, and P. F. Kantor
Left Ventricular Diastolic Mechanical Dyssynchrony and Associated Clinical Outcomes in Children With Dilated Cardiomyopathy
Circ Cardiovasc Imaging, July 1, 2008; 1(1): 50 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
F. W. Prinzen and A. Auricchio
Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Not Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available
Circ Cardiovasc Imaging, July 1, 2008; 1(1): 70 - 78.
[Full Text] [PDF]

Home page
 Circ Cardiovasc ImagingHome page
J. Abraham and T. P. Abraham
Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available
Circ Cardiovasc Imaging, July 1, 2008; 1(1): 79 - 85.
[Full Text] [PDF]

Home page
 Circ Arrhythm ElectrophysiolHome page
M. O. Sweeney and F. W. Prinzen
Ventricular Pump Function and Pacing: Physiological and Clinical Integration
Circ Arrhythm Electrophysiol, June 1, 2008; 1(2): 127 - 139.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. Delgado, C. Ypenburg, R. J. van Bommel, L. F. Tops, S. A. Mollema, N. A. Marsan, G. B. Bleeker, M. J. Schalij, and J. J. Bax
Assessment of Left Ventricular Dyssynchrony by Speckle Tracking Strain Imaging: Comparison Between Longitudinal, Circumferential, and Radial Strain in Cardiac Resynchronization Therapy
J. Am. Coll. Cardiol., May 20, 2008; 51(20): 1944 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
M. Haghjoo, A. Bagherzadeh, M. M. Farahani, Z. O. Haghighi, and M. A. Sadr-Ameli
Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects
Europace, May 1, 2008; 10(5): 566 - 571.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Chakir, S. K. Daya, R. S. Tunin, R. H. Helm, M. J. Byrne, V. L. Dimaano, A. C. Lardo, T. P. Abraham, G. F. Tomaselli, and D. A. Kass
Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization
Circulation, March 18, 2008; 117(11): 1369 - 1377.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. A. Kass
An epidemic of dyssynchrony: but what does it mean?
J. Am. Coll. Cardiol., January 1, 2008; 51(1): 12 - 17.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
S S. Barold and B. Herwerg
Pacing in heart failure: how many leads and where?
Heart, January 1, 2008; 94(1): 10 - 12.
[Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
C. Butter and G. Hindricks
Cardiac resynchronization therapy: haemodynamic background and perspectives
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_I): I87 - I93.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
M. W. Kimmel, N. D. Skadsberg, C. L. Byrd, D. J. Wright, T. G. Laske, and P. A. Iaizzo
Single-site ventricular and biventricular pacing: investigation of latest depolarization strategy
Europace, December 1, 2007; 9(12): 1163 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. P. Abraham, V. L. Dimaano, and H.-Y. Liang
Role of Tissue Doppler and Strain Echocardiography in Current Clinical Practice
Circulation, November 27, 2007; 116(22): 2597 - 2609.
[Full Text] [PDF]

Home page
 HeartHome page
R E Lane, A W C Chow, J Mayet, D P Francis, N S Peters, R J Schilling, and D W Davies
The interaction of interventricular pacing intervals and left ventricular lead position during temporary biventricular pacing evaluated by tissue Doppler imaging
Heart, November 1, 2007; 93(11): 1426 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Johnson, H. K. Kim, M. Tanabe, J. Gorcsan, D. Schwartzman, S. G. Shroff, and M. R. Pinsky
Differential effects of left ventricular pacing sites in an acute canine model of contraction dyssynchrony
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3046 - H3055.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. J. Byrne, R. H. Helm, S. Daya, N. F. Osman, H. R. Halperin, R. D. Berger, D. A. Kass, and A. C. Lardo
Diminished Left Ventricular Dyssynchrony and Impact of Resynchronization in Failing Hearts With Right Versus Left Bundle Branch Block
J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1484 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
C Leclercq
Importance of concordance between left ventricular pacing sites and latest activated regions: myth or reality?
Heart, October 1, 2007; 93(10): 1170 - 1172.
[Full Text] [PDF]

Home page
 EuropaceHome page
A. Sirker, M. Thomas, S. Baker, J. Shrimpton, S. Jewell, L. Lee, R. Rankin, V. Griffiths, N. Cooter, R. James, et al.
Cardiac resynchronization therapy: left or left-and-right for optimal symptomatic effect the LOLA ROSE study
Europace, October 1, 2007; 9(10): 862 - 868.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. A. Kass
Highlighting the R in CRT
Circulation, September 25, 2007; 116(13): 1434 - 1436.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
K. Vernooy, R. N.M. Cornelussen, X. A.A.M. Verbeek, W. Y.R. Vanagt, A. van Hunnik, M. Kuiper, T. Arts, H. J.G.M. Crijns, and F. W. Prinzen
Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts
Eur. Heart J., September 1, 2007; 28(17): 2148 - 2155.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. H. Helm, M. Byrne, P. A. Helm, S. K. Daya, N. F. Osman, R. Tunin, H. R. Halperin, R. D. Berger, D. A. Kass, and A. C. Lardo
Three-Dimensional Mapping of Optimal Left Ventricular Pacing Site for Cardiac Resynchronization
Circulation, February 27, 2007; 115(8): 953 - 961.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
S.-M. Park, K.-C. Kim, M.-J. Jeon, C.-K. Lee, D.-H. Kim, K.-S. Park, W.-H. Lee, and J. Kwan
Assessment of left ventricular asynchrony using volume--time curves of 16 segments by real-time 3 dimensional echocardiography: Comparison with tissue Doppler imaging
Eur J Heart Fail, January 1, 2007; 9(1): 62 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. B. Velimirovic
Ventricular myocardial band concept and ventricular resynchronization device therapy: crossing the roads?
Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 816 - 817.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. A. Quinn, G. Berberian, S. E. Cabreriza, L. J. Maskin, A. D. Weinberg, J. W. Holmes, and H. M. Spotnitz
Effects of sequential biventricular pacing during acute right ventricular pressure overload
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2380 - H2387.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. M. Duncan, E. Lim, J. Clague, D. G. Gibson, and M. Y. Henein
Comparison of segmental and global markers of dyssynchrony in predicting clinical response to cardiac resynchronization
Eur. Heart J., October 2, 2006; 27(20): 2426 - 2432.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
N. M. Hawkins, M. C. Petrie, M. R. MacDonald, K. J. Hogg, and J. J.V. McMurray
Selecting patients for cardiac resynchronization therapy: electrical or mechanical dyssynchrony?
Eur. Heart J., June 1, 2006; 27(11): 1270 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. J.M. Westenberg, H. J. Lamb, R. J. van der Geest, G. B. Bleeker, E. R. Holman, M. J. Schalij, A. de Roos, E. E. van der Wall, J. H.C. Reiber, and J. J. Bax
Assessment of Left Ventricular Dyssynchrony in Patients With Conduction Delay and Idiopathic Dilated Cardiomyopathy: Head-to-Head Comparison Between Tissue Doppler Imaging and Velocity-Encoded Magnetic Resonance Imaging
J. Am. Coll. Cardiol., May 16, 2006; 47(10): 2042 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Donal, C. Leclercq, C. Linde, and J.-C. Daubert
Effects of cardiac resynchronization therapy on disease progression in chronic heart failure
Eur. Heart J., May 1, 2006; 27(9): 1018 - 1025.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Steendijk, S. A. Tulner, J. J. Bax, P. V. Oemrawsingh, G. B. Bleeker, L. van Erven, H. Putter, H. F. Verwey, E. E. van der Wall, and M. J. Schalij
Hemodynamic Effects of Long-Term Cardiac Resynchronization Therapy: Analysis by Pressure-Volume Loops
Circulation, March 14, 2006; 113(10): 1295 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. A. A. M. Verbeek, A. Auricchio, Y. Yu, J. Ding, T. Pochet, K. Vernooy, A. Kramer, J. Spinelli, and F. W. Prinzen
Tailoring cardiac resynchronization therapy using interventricular asynchrony. Validation of a simple model
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H968 - H977.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. A. Kass
Cardiac Resynchronization Therapy and Cardiac Reserve: How You Climb a Staircase May Alter Its Steepness
Circulation, February 21, 2006; 113(7): 923 - 925.
[Full Text] [PDF]

Home page
 CirculationHome page
D. Vollmann, L. Luthje, P. Schott, G. Hasenfuss, and C. Unterberg-Buchwald
Biventricular Pacing Improves the Blunted Force-Frequency Relation Present During Univentricular Pacing in Patients With Heart Failure and Conduction Delay
Circulation, February 21, 2006; 113(7): 953 - 959.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow
Evidence of Structural Remodeling in the Dyssynchronous Failing Heart
Circ. Res., January 6, 2006; 98(1): 125 - 132.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
C. Leclercq, G. Ansalone, F. Gadler, G. Boriani, N. Perez-Castellano, N. Grubb, S. Sack, and E. Boulogne
Biventricular vs. left univentricular pacing in heart failure: rationale, design, and endpoints of the B-LEFT HF study.
Europace, January 1, 2006; 8(1): 76 - 80.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
P. Dilaveris, A. Pantazis, G. Giannopoulos, A. Synetos, J. Gialafos, and C. Stefanadis
Upgrade to biventricular pacing in patients with pacing-induced heart failure: can resynchronization do the trick?
Europace, January 1, 2006; 8(5): 352 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
S Ellery, L Williams, and M Frenneaux
Role of resynchronisation therapy and implantable cardioverter defibrillators in heart failure
Postgrad. Med. J., January 1, 2006; 82(963): 16 - 23.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Kashani and S. S. Barold
Significance of QRS Complex Duration in Patients With Heart Failure
J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2183 - 2192.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. C. Lardo, T. P. Abraham, and D. A. Kass
Magnetic Resonance Imaging Assessment of Ventricular Dyssynchrony: Current and Emerging Concepts
J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2223 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. Carson, I. Anand, C. O'Connor, B. Jaski, J. Steinberg, A. Lwin, J. Lindenfeld, J. Ghali, J. H. Barnet, A. M. Feldman, et al.
Mode of Death in Advanced Heart Failure: The Comparison of Medical, Pacing, and Defibrillation Therapies in Heart Failure (COMPANION) Trial
J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2329 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. C. P. Kerckhoffs, O. P. Faris, P. H. M. Bovendeerd, F. W. Prinzen, K. Smits, E. R. McVeigh, and T. Arts
Electromechanics of paced left ventricle simulated by straightforward mathematical model: comparison with experiments
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1889 - H1897.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Ashikaga, S. R. Mickelsen, D. B. Ennis, I. Rodriguez, P. Kellman, H. Wen, and E. R. McVeigh
Electromechanical analysis of infarct border zone in chronic myocardial infarction
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1099 - H1105.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. D. Spragg, F. G. Akar, R. H. Helm, R. S. Tunin, G. F. Tomaselli, and D. A. Kass
Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts
Cardiovasc Res, July 1, 2005; 67(1): 77 - 86.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. H. Helm, C. Leclercq, O. P. Faris, C. Ozturk, E. McVeigh, A. C. Lardo, and D. A. Kass
Cardiac Dyssynchrony Analysis Using Circumferential Versus Longitudinal Strain: Implications for Assessing Cardiac Resynchronization
Circulation, May 31, 2005; 111(21): 2760 - 2767.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
V. Melenovsky, I. Hay, B. J. Fetics, B. A. Borlaug, A. Kramer, J. M. Pastore, R. Berger, and D. A. Kass
Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy
Eur. Heart J., April 1, 2005; 26(7): 705 - 711.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
U. Tedrow, W. H. Maisel, L. M. Epstein, K. Soejima, and W. G. Stevenson
Feasibility of adjusting paced left ventricular activation by manipulating stimulus strength
J. Am. Coll. Cardiol., December 7, 2004; 44(11): 2249 - 2252.
[Full Text] [PDF]

Home page
 HeartHome page
R A Bleasdale and M P Frenneaux
Cardiac resynchronisation therapy: when the drugs don't work.
Heart, December 1, 2004; 90(suppl_6): vi2 - vi4.
[Full Text] [PDF]

Home page
 HeartHome page
R E Lane, A W C Chow, D Chin, and J Mayet
Selection and optimisation of biventricular pacing: the role of echocardiography
Heart, December 1, 2004; 90(suppl_6): vi10 - vi16.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
I. Hay, V. Melenovsky, B. J. Fetics, D. P. Judge, A. Kramer, J. Spinelli, C. Reister, D. A. Kass, and R. D. Berger
Short-Term Effects of Right-Left Heart Sequential Cardiac Resynchronization in Patients With Heart Failure, Chronic Atrial Fibrillation, and Atrioventricular Nodal Block
Circulation, November 30, 2004; 110(22): 3404 - 3410.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
L. Faber, B. Lamp, J. Vogt, and D. Horstkotte
Tissue Doppler imaging in patients with congestive heart failure and conduction disorders
Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D10 - D15.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Steendijk, S. A.F. Tulner, M. Wiemer, R. A. Bleasdale, J. J. Bax, E. E. van der Wall, J. Vogt, and M. J. Schalij
Pressure-volume measurements by conductance catheter during cardiac resynchronization therapy
Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D35 - D42.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. J. Bax, G. Ansalone, O. A. Breithardt, G. Derumeaux, C. Leclercq, M. J. Schalij, P. Sogaard, M. St. John Sutton, and P. Nihoyannopoulos
Echocardiographic evaluation of cardiac resynchronization therapy: ready for routine clinical use?: A critical appraisal
J. Am. Coll. Cardiol., July 7, 2004; 44(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. S. Turner, R. A. Bleasdale, D. Vinereanu, C. E. Mumford, V. Paul, A. G. Fraser, and M. P. Frenneaux
Electrical and Mechanical Components of Dyssynchrony in Heart Failure Patients With Normal QRS Duration and Left Bundle-Branch Block: Impact of Left and Biventricular Pacing
Circulation, June 1, 2004; 109(21): 2544 - 2549.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A Auricchio and C M Yu
Beyond the measurement of QRS complex toward mechanical dyssynchrony: cardiac resynchronisation therapy in heart failure patients with a normal QRS duration
Heart, May 1, 2004; 90(5): 479 - 481.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
P D. Bella and C Carbucicchio
Non-contact left ventricular endocardial mapping for cardiac resynchronisation therapy: a "slow conduction" towards the fast solution
Heart, May 1, 2004; 90(5): 483 - 484.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M S Turner, R A Bleasdale, C E Mumford, M P Frenneaux, and J A Morris-Thurgood
Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration
Heart, May 1, 2004; 90(5): 502 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. M. Zwanenburg, M. J. W. Gotte, J. P. A. Kuijer, R. M. Heethaar, A. C. van Rossum, and J. T. Marcus
Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1872 - H1880.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. G. Stevenson and M. O. Sweeney
Single Site Left Ventricular Pacing for Cardiac Resynchronization
Circulation, April 13, 2004; 109(14): 1694 - 1696.
[Full Text] [PDF]

Home page
 CirculationHome page
J.-J. Blanc, V. Bertault-Valls, M. Fatemi, M. Gilard, P.-Y. Pennec, and Y. Etienne
Midterm Benefits of Left Univentricular Pacing in Patients With Congestive Heart Failure
Circulation, April 13, 2004; 109(14): 1741 - 1744.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. R. Mehra and B. H. Greenberg
Cardiac resynchronization therapy: caveat medicus!
J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1145 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Penicka, J. Bartunek, B. De Bruyne, M. Vanderheyden, M. Goethals, M. De Zutter, P. Brugada, and P. Geelen
Improvement of Left Ventricular Function After Cardiac Resynchronization Therapy Is Predicted by Tissue Doppler Imaging Echocardiography
Circulation, March 2, 2004; 109(8): 978 - 983.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Steendijk, S. A. F. Tulner, J. J. Schreuder, J. J. Bax, L. van Erven, E. E. van der Wall, R. A. E. Dion, M. J. Schalij, and J. Baan
Quantification of left ventricular mechanical dyssynchrony by conductance catheter in heart failure patients
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H723 - H730.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Leclercq and J. M. Hare
Ventricular Resynchronization: Current State of the Art
Circulation, January 27, 2004; 109(3): 296 - 299.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Bader, S. Garrigue, S. Lafitte, S. Reuter, P. Jais, M. Haissaguerre, J. Bonnet, J. Clementy, and R. Roudaut
Intra-left ventricular electromechanical asynchrony: A new independent predictor of severe cardiac events in heart failure patients
J. Am. Coll. Cardiol., January 21, 2004; 43(2): 248 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Auricchio, C. Stellbrink, C. Butter, S. Sack, J. Vogt, A. R. Misier, D. Bocker, M. Block, J. H. Kirkels, Pacing Therapies in Congestive Heart Failure (PATH, et al.
Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay
J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2109 - 2116.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. A. Kass
Predicting cardiac resynchronization response by qrs duration: The long and short of it
J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2125 - 2127.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. P. Faris, F. J. Evans, A. J. Dick, V. K. Raman, D. B. Ennis, D. A. Kass, and E. R. McVeigh
Endocardial versus epicardial electrical synchrony during LV free-wall pacing
Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1864 - H1870.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
L. Warner Stevenson
The points for pacing
J. Am. Coll. Cardiol., October 15, 2003; 42(8): 1460 - 1462.
[Full Text] [PDF]

Home page
 CirculationHome page
D. D. Spragg, C. Leclercq, M. Loghmani, O. P. Faris, R. S. Tunin, D. DiSilvestre, E. R. McVeigh, G. F. Tomaselli, and D. A. Kass
Regional Alterations in Protein Expression in the Dyssynchronous Failing Heart
Circulation, August 26, 2003; 108(8): 929 - 932.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
X. A. A. M. Verbeek, K. Vernooy, M. Peschar, R. N. M. Cornelussen, and F. W. Prinzen
Intra-ventricular resynchronization for optimal left ventricular function during pacing in experimental left bundle branch block
J. Am. Coll. Cardiol., August 6, 2003; 42(3): 558 - 567.
[Abstract] [Full Text] [PDF]


Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2002 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.