Circulation. 2002;106:1814-1820
Published online before print September 9, 2002, doi: 10.1161/01.CIR.0000031798.07790.FE
Published online before print September 9, 2002, doi: 10.1161/01.CIR.0000031798.07790.FE
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:1814.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Autonomic Neural Control of Dynamic Cerebral Autoregulation in Humans
From the Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and the University of Texas Southwestern Medical Center at Dallas, Tex.
Correspondence to Benjamin D. Levine, MD, Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231. E-mail BenjaminLevine{at}TexasHealth.org
Background— The purpose of the present study was to determine the role of autonomic neural control of dynamic cerebral autoregulation in humans.
Methods and Results— We measured arterial pressure and cerebral blood flow (CBF) velocity in 12 healthy subjects (aged 29±6 years) before and after ganglion blockade with trimethaphan. CBF velocity was measured in the middle cerebral artery using transcranial Doppler. The magnitude of spontaneous changes in mean blood pressure and CBF velocity were quantified by spectral analysis. The transfer function gain, phase, and coherence between these variables were estimated to quantify dynamic cerebral autoregulation. After ganglion blockade, systolic and pulse pressure decreased significantly by 13% and 26%, respectively. CBF velocity decreased by 6% (P<0.05). In the very low frequency range (0.02 to 0.07 Hz), mean blood pressure variability decreased significantly (by 82%), while CBF velocity variability persisted. Thus, transfer function gain increased by 81%. In addition, the phase lead of CBF velocity to arterial pressure diminished. These changes in transfer function gain and phase persisted despite restoration of arterial pressure by infusion of phenylephrine and normalization of mean blood pressure variability by oscillatory lower body negative pressure.
Conclusions— These data suggest that dynamic cerebral autoregulation is altered by ganglion blockade. We speculate that autonomic neural control of the cerebral circulation is tonically active and likely plays a significant role in the regulation of beat-to-beat CBF in humans.
Key Words: blood flow • brain • nervous system, autonomic • ultrasonics
This article has been cited by other articles:
 |
|
 |
|
  R. M. Brothers, R. Zhang, J. E. Wingo, K. A. Hubing, and C. G. Crandall Effects of heat stress on dynamic cerebral autoregulation during large fluctuations in arterial blood pressure J Appl Physiol, December 1, 2009; 107(6): 1722 - 1729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh and P. N. Ainslie Cerebral blood flow during exercise: mechanisms of regulation J Appl Physiol, November 1, 2009; 107(5): 1370 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Subudhi, R. B. Panerai, and R. C. Roach Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques J Appl Physiol, October 1, 2009; 107(4): 1165 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Thomas, J. D. Cotter, S. D. Galvin, M. J. A. Williams, C. K. Willie, and P. N. Ainslie Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects J Appl Physiol, August 1, 2009; 107(2): 506 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Brothers, J. E. Wingo, K. A. Hubing, and C. G. Crandall The effects of reduced end-tidal carbon dioxide tension on cerebral blood flow during heat stress J. Physiol., August 1, 2009; 587(15): 3921 - 3927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang, K. Behbehani, and B. D. Levine Dynamic pressure\#8211;flow relationship of the cerebral circulation during acute increase in arterial pressure J. Physiol., June 1, 2009; 587(11): 2567 - 2577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Mitchell, G. Lambert, N. H. Secher, P. B. Raven, J. van Lieshout, and M. D. Esler Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans J. Physiol., June 1, 2009; 587(11): 2589 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Ainslie and J. Duffin Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1473 - R1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Low, J. E. Wingo, D. M. Keller, S. L. Davis, J. Cui, R. Zhang, and C. G. Crandall Dynamic cerebral autoregulation during passive heat stress in humans Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1598 - R1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. H. R. Claassen, B. D. Levine, and R. Zhang Dynamic cerebral autoregulation during repeated squat-stand maneuvers J Appl Physiol, January 1, 2009; 106(1): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Urbano, F. Roux, J. Schindler, and V. Mohsenin Impaired cerebral autoregulation in obstructive sleep apnea J Appl Physiol, December 1, 2008; 105(6): 1852 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Porta, G Casucci, S Castoldi, A Rinaldi, and L Bernardi Influence of respiratory instability during neurocardiogenic presyncope on cerebrovascular and cardiovascular dynamics Heart, November 1, 2008; 94(11): 1433 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ogoh Response to Letter by Prakash Stroke, November 1, 2008; 39(11): e168 - e169. [Full Text] [PDF]
|
|
|
|
|
|
B. D. Levine, R. Zhang, M. Visocchi, P. N. Ainslie, S. Ogoh, L. Edvinsson, M. Yildiz, O. B. Paulson, G. M. Knudsen, P. A. Cassaglia, et al. Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow J Appl Physiol, October 1, 2008; 105(4): 1369 - 1373. [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. I. Lucas, J. D. Cotter, S. Morrison, and P. N. Ainslie The effects of ageing and passive heating on cardiorespiratory and cerebrovascular responses to orthostatic stress in humans Exp Physiol, October 1, 2008; 93(10): 1104 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Fisher, S. Ogoh, C. N. Young, P. B. Raven, and P. J. Fadel Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging J Appl Physiol, July 1, 2008; 105(1): 266 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, R. M. Brothers, W. L. Eubank, and P. B. Raven Autonomic Neural Control of the Cerebral Vasculature: Acute Hypotension Stroke, July 1, 2008; 39(7): 1979 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Strempel, C. Schroeder, R. Hemmersbach, A. Boese, J. Tank, A. Diedrich, M. Heer, F. C. Luft, and J. Jordan Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation J Appl Physiol, March 1, 2008; 104(3): 756 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Y. Wong, T. S. Leung, T. Austin, M. Wilkinson, J. H. Meek, J. S. Wyatt, and A. M. Walker Impaired Autoregulation in Preterm Infants Identified by Using Spatially Resolved Spectroscopy Pediatrics, March 1, 2008; 121(3): e604 - e611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Ainslie, S. Ogoh, K. Burgess, L. Celi, K. McGrattan, K. Peebles, C. Murrell, P. Subedi, and K. R. Burgess Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia J Appl Physiol, February 1, 2008; 104(2): 490 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ogawa, K.-i. Iwasaki, K. Aoki, S. Shibata, J. Kato, and S. Ogawa Central Hypervolemia with Hemodilution Impairs Dynamic Cerebral Autoregulation Anesth. Analg., November 1, 2007; 105(5): 1389 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang and B. D. Levine Autonomic Ganglionic Blockade Does Not Prevent Reduction in Cerebral Blood Flow Velocity During Orthostasis in Humans Stroke, April 1, 2007; 38(4): 1238 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Iwasaki, B. D. Levine, R. Zhang, J. H. Zuckerman, J. A. Pawelczyk, A. Diedrich, A. C. Ertl, J. F. Cox, W. H. Cooke, C. A. Giller, et al. Human cerebral autoregulation before, during and after spaceflight J. Physiol., March 15, 2007; 579(3): 799 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Carter III, S. N. Cheuvront, C. R. Vernieuw, and M. N. Sawka Hypohydration and prior heat stress exacerbates decreases in cerebral blood flow velocity during standing J Appl Physiol, December 1, 2006; 101(6): 1744 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lavi, D. Gaitini, V. Milloul, and G. Jacob Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1856 - H1861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Mitsis, R. Zhang, B. D. Levine, and V. Z. Marmarelis Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling J Appl Physiol, July 1, 2006; 101(1): 354 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guo, N. Tierney, F. Schaller, P. B. Raven, S. A. Smith, and X. Shi Cerebral autoregulation is preserved during orthostatic stress superimposed with systemic hypotension J Appl Physiol, June 1, 2006; 100(6): 1785 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A F Folino Cerebral autoregulation in neurally mediated syncope: victim or executioner? Heart, June 1, 2006; 92(6): 724 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S W Parry, N Steen, M Baptist, K A Fiaschi, O Parry, and R A Kenny Cerebral autoregulation is impaired in cardioinhibitory carotid sinus syndrome Heart, June 1, 2006; 92(6): 792 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ogawa, K.-i. Iwasaki, S. Shibata, J. Kato, S. Ogawa, and Y. Oi The Effect of Sevoflurane on Dynamic Cerebral Blood Flow Autoregulation Assessed by Spectral and Transfer Function Analysis Anesth. Analg., February 1, 2006; 102(2): 552 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, R. M. Brothers, Q. Barnes, W. L. Eubank, M. N. Hawkins, S. Purkayastha, A. O-Yurvati, and P. B. Raven The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise J. Physiol., December 1, 2005; 569(2): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Latka, M. Turalska, M. Glaubic-Latka, W. Kolodziej, D. Latka, and B. J. West Phase dynamics in cerebral autoregulation Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2272 - H2279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kotajima, G. E Meadows, M. J Morrell, and D. R Corfield Cerebral blood flow changes associated with fluctuations in alpha and theta rhythm during sleep onset in humans J. Physiol., October 1, 2005; 568(1): 305 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Guo, F. Schaller, N. Tierney, S. A. Smith, and X. Shi New Insight into the Mechanism of Cardiovascular Dysfunction in the Elderly: Transfer Function Analysis Experimental Biology and Medicine, September 1, 2005; 230(8): 549 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schondorf, J. Benoit, and R. Stein Cerebral autoregulation is preserved in postural tachycardia syndrome J Appl Physiol, September 1, 2005; 99(3): 828 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muller and M. Marziniak The Linear Behavior of the System Middle Cerebral Artery Flow Velocity and Blood Pressure in Patients With Migraine: Lack of Autonomic Control? Stroke, September 1, 2005; 36(9): 1886 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Panerai, M. Moody, P. J. Eames, and J. F. Potter Dynamic cerebral autoregulation during brain activation paradigms Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1202 - H1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Thengchaisri and R. J. Rivers Remote arteriolar dilations caused by methacholine: a role for CGRP sensory nerves? Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H608 - H613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N Ainslie, J. C Ashmead, K. Ide, B. J Morgan, and M. J Poulin Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans J. Physiol., July 15, 2005; 566(2): 613 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, J. P Fisher, E. A Dawson, M. J White, N. H Secher, and P. B Raven Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans J. Physiol., July 15, 2005; 566(2): 599 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Wilson, R. Zhang, B. D. Levine, and C. G. Crandall Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H385 - H391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, P. J. Fadel, R. Zhang, C. Selmer, O. Jans, N. H. Secher, and P. B. Raven Middle cerebral artery flow velocity and pulse pressure during dynamic exercise in humans Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1526 - H1531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, M. K. Dalsgaard, C. C. Yoshiga, E. A. Dawson, D. M. Keller, P. B. Raven, and N. H. Secher Dynamic cerebral autoregulation during exhaustive exercise in humans Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1461 - H1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hamner, M. A. Cohen, S. Mukai, L. A. Lipsitz, and J. A. Taylor Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations J. Physiol., September 15, 2004; 559(3): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Durand, R. Zhang, J. Cui, T. E. Wilson, and C. G. Crandall Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations J Appl Physiol, August 1, 2004; 97(2): 535 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Cooke, J. R. Carter, and T. A. Kuusela Human cerebrovascular and autonomic rhythms during vestibular activation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R838 - R843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang, C. G. Crandall, and B. D. Levine Cerebral Hemodynamics During the Valsalva Maneuver: Insights From Ganglionic Blockade Stroke, April 1, 2004; 35(4): 843 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Cooke, G. L. Pellegrini, and O. A. Kovalenko Dynamic cerebral autoregulation is preserved during acute head-down tilt J Appl Physiol, October 1, 2003; 95(4): 1439 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J van Lieshout and W. Wieling Perfusion of the human brain: a matter of interactions J. Physiol., September 1, 2003; 551(2): 402 - 402. [Full Text] [PDF]
|
|
|
|
|
|
M. Brys, C. M. Brown, H. Marthol, R. Franta, and M. J. Hilz Dynamic cerebral autoregulation remains stable during physical challenge in healthy persons Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1048 - H1054. [Abstract] [Full Text] [PDF]
|
|