Circulation. 2002;106:1913-1918
Published online before print September 3, 2002, doi: 10.1161/01.CIR.0000034046.87607.1C
Published online before print September 3, 2002, doi: 10.1161/01.CIR.0000034046.87607.1C
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(Circulation. 2002;106:1913.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans
From the Department of Medicine, Division of Cardiology (B.E.S., M.B., T.Z., M.K.) and Institute for Transplantation Diagnostics and Cell Therapeutics (A.H., R.V.S., G.K., P.W.), Heinrich-Heine-University of Düsseldorf, Germany.
Correspondence to Professor Dr Bodo E. Strauer, Department of Medicine, Division of Cardiology, Heinrich-Heine-University, Moorenstr 5, 40225 Düsseldorf, Germany. E-mail Strauer{at}med.uni-duesseldorf.de
Background— Experimental data suggest that bone marrow–derived cells may contribute to the healing of myocardial infarction (MI). For this reason, we analyzed 10 patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI.
Methods and Results— After standard therapy for acute MI, 10 patients were transplanted with autologous mononuclear BMCs via a balloon catheter placed into the infarct-related artery during balloon dilatation (percutaneous transluminal coronary angioplasty). Another 10 patients with acute MI were treated by standard therapy alone. After 3 months of follow-up, the infarct region (determined by left ventriculography) had decreased significantly within the cell therapy group (from 30±13 to 12±7%, P=0.005) and was also significantly smaller compared with the standard therapy group (P=0.04). Likewise, infarction wall movement velocity increased significantly only in the cell therapy group (from 2.0±1.1 to 4.0±2.6 cm/s, P=0.028). Further cardiac examinations (dobutamine stress echocardiography, radionuclide ventriculography, and catheterization of the right heart) were performed for the cell therapy group and showed significant improvement in stroke volume index, left ventricular end-systolic volume and contractility (ratio of systolic pressure and end-systolic volume), and myocardial perfusion of the infarct region.
Conclusions— These results demonstrate for the first time that selective intracoronary transplantation of autologous, mononuclear BMCs is safe and seems to be effective under clinical conditions. The marked therapeutic effect may be attributed to BMC-associated myocardial regeneration and neovascularization.
Key Words: myocardial infarction • cell transplantation, intracoronary • angiogenesis • bone marrow • myogenesis
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S. L.M.A. Beeres, F. M. Bengel, J. Bartunek, D. E. Atsma, J. M. Hill, M. Vanderheyden, M. Penicka, M. J. Schalij, W. Wijns, and J. J. Bax Role of Imaging in Cardiac Stem Cell Therapy J. Am. Coll. Cardiol., March 20, 2007; 49(11): 1137 - 1148. [Abstract] [Full Text] [PDF]
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S. Vandervelde, M. J.A. van Luyn, M. H. Rozenbaum, A. H. Petersen, R. A. Tio, and M. C. Harmsen Stem cell-related cardiac gene expression early after murine myocardial infarction Cardiovasc Res, March 1, 2007; 73(4): 783 - 793. [Abstract] [Full Text] [PDF]
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B. A. Pallante, I. Duignan, D. Okin, A. Chin, M. C. Bressan, T. Mikawa, and J. M. Edelberg Bone Marrow Oct3/4+ Cells Differentiate Into Cardiac Myocytes via Age-Dependent Paracrine Mechanisms Circ. Res., January 5, 2007; 100(1): e1 - e11. [Abstract] [Full Text] [PDF]
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A. Aicher, C. Heeschen, K.-i. Sasaki, C. Urbich, A. M. Zeiher, and S. Dimmeler Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia Circulation, December 19, 2006; 114(25): 2823 - 2830. [Abstract] [Full Text] [PDF]
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S. T. Wall, J. C. Walker, K. E. Healy, M. B. Ratcliffe, and J. M. Guccione Theoretical Impact of the Injection of Material Into the Myocardium: A Finite Element Model Simulation Circulation, December 12, 2006; 114(24): 2627 - 2635. [Abstract] [Full Text] [PDF]
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M Saha, R Zbinden, S R Redwood, and M S Marber Stem cells to repair the broken heart: much ado about nothing? Heart, December 1, 2006; 92(12): 1717 - 1719. [Abstract] [Full Text] [PDF]
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S. Seth, R. Narang, B. Bhargava, R. Ray, S. Mohanty, G. Gulati, L. Kumar, K. S. Reddy, P. Venugopal, and AIIMS Cardiovascular Stem Cell Study Group Percutaneous Intracoronary Cellular Cardiomyoplasty for Nonischemic Cardiomyopathy: Clinical and Histopathological Results: The First-in-Man ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) Trial J. Am. Coll. Cardiol., November 10, 2006; (2006) j.jacc.2006.07.057v1. [Full Text] [PDF]
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C. Kubal, K. Sheth, B. Nadal-Ginard, and M. Galinanes Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans. J. Thorac. Cardiovasc. Surg., November 1, 2006; 132(5): 1112 - 1118. [Abstract] [Full Text] [PDF]
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M. R. Rosen Are Stem Cells Drugs?: The Regulation of Stem Cell Research and Development Circulation, October 31, 2006; 114(18): 1992 - 2000. [Abstract] [Full Text] [PDF]
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I. Ben-Dor, S. Fuchs, and R. Kornowski Potential Hazards and Technical Considerations Associated With Myocardial Cell Transplantation Protocols for Ischemic Myocardial Syndrome J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1519 - 1526. [Abstract] [Full Text] [PDF]
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H. Guven, R. M. Shepherd, R. G. Bach, B. J. Capoccia, and D. C. Link The Number of Endothelial Progenitor Cell Colonies in the Blood Is Increased in Patients With Angiographically Significant Coronary Artery Disease J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1579 - 1587. [Abstract] [Full Text] [PDF]
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H. Hata, G. Matsumiya, S. Miyagawa, H. Kondoh, N. Kawaguchi, N. Matsuura, T. Shimizu, T. Okano, H. Matsuda, and Y. Sawa Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 918 - 924. [Abstract] [Full Text] [PDF]
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K.-L. Ang, L. Takura Shenje, L. Srinivasan, and M. Galinanes Repair of the damaged heart by bone marrow cells: from experimental evidence to clinical hope. Ann. Thorac. Surg., October 1, 2006; 82(4): 1549 - 1558. [Abstract] [Full Text] [PDF]
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S. Roura, J. Farre, C. Soler-Botija, A. Llach, L. Hove-Madsen, J. J. Cairo, F. Godia, J. Cinca, and A. Bayes-Genis Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells Eur J Heart Fail, October 1, 2006; 8(6): 555 - 563. [Abstract] [Full Text] [PDF]
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J. Honold, R. Lehmann, C. Heeschen, D. H. Walter, B. Assmus, K.-I. Sasaki, H. Martin, J. Haendeler, A. M. Zeiher, and S. Dimmeler Effects of Granulocyte Colony Stimulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients With Chronic Ischemic Heart Disease Arterioscler Thromb Vasc Biol, October 1, 2006; 26(10): 2238 - 2243. [Abstract] [Full Text] [PDF]
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 K. Lunde, S. Solheim, S. Aakhus, H. Arnesen, M. Abdelnoor, T. Egeland, K. Endresen, A. Ilebekk, A. Mangschau, J. G. Fjeld, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N. Engl. J. Med., September 21, 2006; 355(12): 1199 - 1209. [Abstract] [Full Text] [PDF]
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