Published online before print September 23, 2002, doi: 10.1161/01.CIR.0000034047.70205.97
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(Circulation. 2002;106:2118.)
© 2002 American Heart Association, Inc.
Basic Science Reports |
Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Simvastatin Prevents Cardiac Hypertrophy Induced by Pressure Overload and Inhibits p21ras Activation
From the Division of Cardiology (C.I., A. Curcio), Magna Graecia University, Catanzaro; Division of Cardiology (E.D.L., C.P., A.M.S., D.T., C.C., L. Cavuto, O.A., M.C.), Department of Medicine (A. Cittadini., L.S.), and Department of Biology and Molecular and Cellular Pathology (L. Cardone, E.V.A.), University Federico II, Naples, Italy.
Correspondence to Ciro Indolfi, MD, FACC, FESC, Division of Cardiology, Magna Graecia University, Via T. Campanella 115, 88100 Catanzaro, Italy. E-mail indolfi{at}unicz.it
Background— Patients with cardiac hypertrophy are at increased cardiovascular risk. It has been hypothesized that hydroxymethylglutaryl coenzyme A reductase inhibitors may exert beneficial effects other than their cholesterol-lowering actions. The aims of the study were to assess the in vivo effects of simvastatin (SIM) on cardiac hypertrophy and on Ras signaling in rats with ascending aorta banding.
Methods and Results— Wistar rats were randomized to receive either treatment with SIM or placebo, and then short-term (group I) and long-term (group II) left ventricular pressure overload was performed by placing a tantalum clip on ascending aorta. At the end of treatment period, left and right ventricular weight, body weight, and tibial length were measured and echocardiographic evaluations were performed. Ras signaling was investigated by analyzing Ras membrane localization and activation, ERK2 phosphorylation, and p27kip1 and cdk4 levels. In SIM-treated rats, a significant reduction of left ventricular weight/body weight, echocardiographic left ventricular mass, and left ventricular end-diastolic diameter and end-diastolic pressure was found. In rats with pressure overload, SIM treatment significantly reduced Ras membrane targeting, Ras in vivo activation, ERK2 phosphorylation, and the ratio cdk4/p27kip1.
Conclusions— HMG CoA inhibitor SIM inhibits in vivo Ras signaling and prevents left ventricular hypertrophy development in aortic-banded animals.
Key Words: hypertrophy • signal transduction • statins • myocardium • pressure
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