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(Circulation. 2002;106:1000.)
© 2002 American Heart Association, Inc.

Basic Science Reports

Stent-Based Approach for Ventricle–to–Coronary Artery Bypass

Peter Boekstegers, MD^*; Philip Raake^*; Rasul Al Ghobainy; Jan Horstkotte; Rabea Hinkel; Torleif Sandner; Reinhard Wichels, MD; Franz Meisner, MD; Eckehard Thein, MD; Keith March, MD, PhD; Dieter Boehm, MD; Hermann Reichenspurner, MD, PhD

From the Department of Internal Medicine I, Grosshadern University Hospital (P.B., P.R., R.A.G., J.H., R.H., T.S., R.W.), and Institute of Surgical Research (F.M., E.T.), Munich, and the Department of Cardiac Surgery, University Hospital Eppendorf, Hamburg (D.B., H.R.), Germany; and the Indiana Center for Vascular Biology and Medicine, Indiana University, Indianapolis, Ind (K.M.).

Correspondence to Prof. Dr. med. Peter Boekstegers, Medizinische Klinik I, Klinikum der Universität-Grosshadern, Marchioninistraße 15, D-81377 München, Germany. E-mail boekstegers{at}med1.med.uni-muenchen.de

Background— Ventricle-to–coronary artery bypass (VCAB) is an experimental revascularization procedure that provides predominantly systolic instead of diastolic blood flow to a coronary artery.

Methods and Results— In a pig model, a stent-based procedure (VSTENT) was developed to create a VCAB. After thoracotomy, a covered VSTENT was implanted between the left ventricle and the left anterior descending coronary artery (LAD). Distal LAD flow, regional myocardial function, and intracoronary pressures were determined at different degrees of LAD stenosis and during complete LAD occlusion. During 3 hours of LAD occlusion, VSTENT preserved net forward flow at 70±6% and regional myocardial function at 71±8% of baseline. Preservation of net flow was influenced by the positioning of the VSTENT, with higher preservation also under conditions of increased oxygen demand if a "valve-like mechanism" was present during diastole. At a hemodynamically relevant level of LAD stenosis (>70%), systolic inflow was predominant after VSTENT implantation. Changes in mean diastolic intracoronary pressure that resulted from different degrees of LAD stenosis were linearly correlated to net flow after VSTENT implantation (r=0.88; P<0.001).

Conclusions— VSTENT for ventricle-to–coronary artery bypass was feasible and preserved 70±6% of baseline flow during complete LAD occlusion. The degree of preservation was dependent on the position of the VSTENT creating a valve-like mechanism during diastole. Residual diastolic blood flow through a high-grade LAD stenosis influenced net flow favorably, because diastolic backflow decreased with increasing mean diastolic intracoronary pressure.

Key Words: arteries • revascularization • shunts • stents

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