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(Circulation. 1955;11:188.)
© 1955 American Heart Association, Inc.

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Cardiovascular Actions of Sodium Nitroprusside in Animals and Hypertensive Patients

IRVINE H. PAGE ¹; A. C. CORCORAN ¹; H. P. DUSTAN ¹; THEODORE KOPPANYI ¹

¹ From the Research Division of the Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute, Cleveland, Ohio and the Department of Pharmacology, Georgetown University School of Medicine, Washington, D. C.

Certain chemical and pharmacological properties of sodium nitroprusside, a cheap, readily available chemical, have been described. It is a powerful hypotensive agent when given intravenously tohypertensive patients. It is no more effective than the sodium thiocyanate into which it is converted when given by mouth. Prolonged infusion has proved highly effective in the treatment of hypertensive encephalopathy.

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