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(Circulation. 1955;11:604.)
© 1955 American Heart Association, Inc.

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The Use of Hexamethonium in Treatment of Arteriosclerosis Obliterans

JOHN H. WINDESHEIM M.D.¹; GRACE M. ROTH PH.D.¹; RAY W. GIFFORD JR. M.D.¹

¹ From the Mayo Foundation, a part of the Graduate School of the University of Minnesota, and the Mayo Clinic, Rochester, Minn.

The effect of hexamethonium on hypertension has been widely studied but its effect on the peripheral blood vessels of patients with severe occlusive vascular disease has been studied on only a few patients although the drug has been used empirically in the treatment of such disease.

Observations were made on the effect of hexamethonium ion administered subcutaneously in increasing doses of 10 to 50 mg. on the skin temperature of the fingers and toes, the blood pressure and the pulse rates of a group of patients with severe arteriosclerosis obliterans. On this group of patients hexamethonium had little or no effect.