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(Circulation. 1955;11:628.)
© 1955 American Heart Association, Inc.

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Effects of Hemorrhagic Shock on the Heart and Circulation of Intact Dogs

DONALD B. HACKEL M.D.¹ WALTER T. GOODALE M.D.¹

¹ From the Department of Pathology, Western Reserve University School of Medicine at City Hospital, Cleveland, Ohio; the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, and the Cardiorespiratory Laboratory, Children's Medical Center, Boston, Massachusetts.

The metabolic, hemodynamic and pathologic effects of hemorrhagic shock on the hearts of intact dogs have been studied, using the technique of venous catheterization of the coronary sinus. Metabolic studies demonstrated an alteration in the pattern of myocardial carbohydrate metabolism during shock and evidence for a relative myocardial oxygen deficiency. Subendocardial hemorrhage or necrosis was found in the left ventricles of some of the dogs.

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