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(Circulation. 1955;11:742.)
© 1955 American Heart Association, Inc.

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The Effect of Cortisone on Experimentally Produced Myocardial Infarcts

NORMAN G. HEPPER M.D.¹; RAYMOND D. PRUITT M.D.¹; DAVID E. DONALD B.V.S., M.R.C.V.S.¹; JESSE E. EDWARDS M.D.¹

¹ From the Mayo Clinic and the Mayo Foundation, part of the Graduate School of the University of Minnesota, Rochester, Minn.

Administration of a moderately large or large dose of cortisone to dogs having acute myocardial infarctions inhibited slightly the rate of removal of necrotic muscle fibers in these animals as compared with untreated animals. Delay was appreciable at four and six days after production of the infarct in animals receiving 2.5 mg. of cortisone per kilogram of body weight and at 4, 6, 12 and 21 days in animals receiving 10 mg. per kilogram. At all other periods up to essentially complete healing of the infarcts as defined at 60 days, no appreciable differences existed between treated and untreated animals.