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(Circulation. 2004;110:10-15.)
© 2004 American Heart Association, Inc.

Original Articles

Effects of Cardiopulmonary Resuscitation on Predictors of Ventricular Fibrillation Defibrillation Success During Out-of-Hospital Cardiac Arrest

Trygve Eftestøl, PhD; Lars Wik, MD, PhD; Kjetil Sunde, MD, PhD; Petter Andreas Steen, MD, PhD

From Stavanger University College, Department of Electrical and Computer Engineering, Stavanger (T.E.), and National Center of Competence in Emergency Medicine, Prehospital Division (L.W., P.A.S.) and Department of Anesthesiology, Surgical Division (K.S., P.A.S.), Ulleval University Hospital, Oslo, Norway.

Correspondence to Trygve Eftestøl, Stavanger University College, Department of Electrical and Computer Engineering, PO Box 8002, 4068 Stavanger, Norway. E-mail trygve.eftestol{at}his.no

Received November 15, 2003; revision received March 10, 2004; accepted March 17, 2004.

Background— Early defibrillation is considered the most important factor for restoring spontaneous circulation in cardiac arrest patients with ventricular fibrillation. Recent studies have shown that, after prolonged ventricular fibrillation, the rates of return of spontaneous circulation (ROSC) and survival are improved if defibrillation is delayed so that CPR can be given first. To examine whether CPR improves myocardial readiness for defibrillation, we analyzed whether CPR causes changes in predictors of defibrillation success calculated from the ventricular fibrillation waveform.

Methods and Results— ECG recordings were retrieved for 105 patients from an original study of 200 patients receiving CPR or defibrillation first. Altogether, 267 CPR sequences from 77 patients were identified on which the effect of CPR could be evaluated. Five predictors of ROSC (spectral flatness measure, energy, centroid frequency, amplitude spectrum relationship, and estimated probability of ROSC) were determined from a spectral analysis of the ventricular fibrillation waveform immediately before and immediately after each of the 267 sequences. CPR increased spectral flatness measure, centroid frequency, and amplitude spectrum relationship (P<0.05, P<0.001, P<0.01). In an analysis of the effect of the duration of CPR, the probability of ROSC and amplitude spectrum relationship showed a positive change for CPR sequences lasting >3 minutes (P<0.001, P<0.05).

Conclusions— During resuscitation from ventricular fibrillation, changes in the predictors calculated from the ventricular fibrillation waveform indicated a positive effect of CPR on the myocardium.

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