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(Circulation. 2004;110:1380-1386.)
© 2004 American Heart Association, Inc.

Original Articles

Relation of Biventricular Function Quantified by Stress Echocardiography to Cardiopulmonary Exercise Capacity in Adults With Mustard (Atrial Switch) Procedure for Transposition of the Great Arteries

Wei Li, MD PhD; Tim S. Hornung, MD; Darrel P. Francis, MRCP; Christine O’Sullivan, BSc; Alison Duncan, MRCP; Michael Gatzoulis, MD PhD; Michael Henein, MD PhD

From Royal Brompton Hospital and Imperial College School of Medicine, London, United Kingdom.

Correspondence to Dr Michael Henein, Department of Echocardiography, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK. E-mail m.henein{at}rbh.nthames.nhs.uk

Received February 27, 2003; de novo received September 26, 2003; revision received April 22, 2004; accepted April 26, 2004.

Background— Mustard repair for transposition of the great arteries (TGA) is frequently associated with impaired systemic (right) ventricular function and sometimes exercise intolerance. We hypothesized that a simple quantitative measurement of ventricular function, during rest and pharmacological stress, could identify abnormalities and predict objective exercise capacity.

Methods and Results— We quantified the performance of systemic and pulmonary (left) ventricles by using echocardiography, at rest and during dobutamine stress, in 27 adults who had undergone Mustard repair for TGA. Systolic and diastolic function of the systemic ventricle were markedly disturbed with respect to pulmonary ventricular function. We also measured exercise capacity by cardiopulmonary exercise testing for peak oxygen uptake. Exercise capacity was significantly predicted by systemic ventricular long-axis excursion both at rest (r=0.66, P<0.001) and at peak dobutamine stress (r=0.53, P=0.006) but not by pulmonary ventricular long-axis excursion at rest (r=0.04) or on stress (r=0.11). Exercise capacity was also predicted by the septal long-axis excursion at rest (r=0.61, P=0.001) but not pulmonary ventricular free wall excursion (P>0.05) or fractional shortening (P>0.05). Peak aortic velocity at maximum dobutamine stress correlated with exercise capacity (r=0.46, P=0.029) but not at rest (r=0.36). Multivariate analysis revealed systemic ventricular long-axis excursion to be the sole significant independent predictor of exercise capacity.

Conclusions— Systemic ventricular function is depressed in most patients with Mustard repair. Quantitative echocardiographic evaluation shows systemic ventricular function to be a key determinant of exercise capacity.

Key Words: transposition of great vessels • echocardiography • exercise

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