Published online before print April 25, 2005, doi: 10.1161/01.CIR.0000163550.70487.0B
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(Circulation. 2005;111:2171-2177.)
© 2005 American Heart Association, Inc.
Epidemiology |
Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition
From the Hypertension Research Center (J.P.G., M.K., X.L., A.A.), the Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, and The Bogalusa Heart Study (S.L., S.R.S., W.C., G.S.B.), Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, La.
Correspondence to Abraham Aviv, MD, Hypertension Research Center, Room F-464, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103. E-mail avivab{at}umdnj.edu
Received August 20, 2004; revision received January 20, 2005; accepted February 23, 2005.
Background— Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition.
Methods and Results— We measured white blood cell telomere dynamics and age-related changes in insulin resistance and body mass index in young adults of the Bogalusa Heart Study. Over 10.1 to 12.8 years, the relative changes in telomere length were correlated with the homeostasis model assessment of insulin resistance (r=–0.531, P<0.001) and changes in the body mass index (r=–0.423, P<0.001).
Conclusions— These findings provide the first tangible nexus of telomere biology with insulin resistance and adiposity in humans.
Key Words: telomere • insulin • obesity • aging • stress
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