Circulation. 2005;112:2143-2148
Published online before print September 26, 2005, doi: 10.1161/CIRCULATIONAHA.105.558122
Published online before print September 26, 2005, doi: 10.1161/CIRCULATIONAHA.105.558122
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2005;112:2143-2148.)
© 2005 American Heart Association, Inc.
Heart Failure |
Postconditioning the Human Heart
From Hôpital Cardiologique et Pneumologique Louis Pradel, Lyon (P.S., G.R., E.B., G.F., X.A.-F., M.O.); Hôpital Arnaud de Villeneuve, Montpellier (C.P., T.T.C.); Hôpital du Bocage, Dijon (Y.C., I.L.); Hôpital Saint Luc–Saint Joseph, Lyon (J.-F.A.); and Inserm E 0226, Lyon (G.R., G.F., M.O.), France.
Correspondence to Professor Michel Ovize, Hôpital L. Pradel, Hospices Civils de Lyon, 59, Bd Pinel, 69394 Lyon Cedex 03, France. E-mail ovize{at}sante.univ-lyon1.fr
Received April 25, 2005; revision received June 2, 2005; accepted June 17, 2005.
Background— In animal models, brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called postconditioning. In this prospective, randomized, controlled, multicenter study, we investigated whether postconditioning may protect the human heart during coronary angioplasty for acute myocardial infarction.
Methods and Results— Thirty patients, submitted to coronary angioplasty for ongoing acute myocardial infarction, contributed to the study. Patients were randomly assigned to either a control or a postconditioning group. After reperfusion by direct stenting, control subjects underwent no further intervention, whereas postconditioning was performed within 1 minute of reflow by 4 episodes of 1-minute inflation and 1-minute deflation of the angioplasty balloon. Infarct size was assessed by measuring total creatine kinase release over 72 hours. Area at risk and collateral blood flow were estimated on left ventricular and coronary angiograms. No adverse events occurred in the postconditioning group. Determinants of infarct size, including ischemia time, size of the area at risk, and collateral flow, were comparable between the 2 groups. Area under the curve of creatine kinase release was significantly reduced in the postconditioning compared with the control group, averaging 208 984±26 576 compared with 326 095±48 779 (arbitrary units) in control subjects, ie, a 36% reduction in infarct size. Blush grade, a marker of myocardial reperfusion, was significantly increased in postconditioned compared with control subjects: 2.44±0.17 versus 1.95±0.27, respectively (P<0.05).
Conclusions— This study suggests that postconditioning by coronary angioplasty protects the human heart during acute myocardial infarction.
Key Words: ischemia • myocardial infarction • postconditioning • reperfusion
Related Article:
Circulation 2005 112: 2077-2078.
This article has been cited by other articles:
 |
|
 |
|
  J. Musiolik, P. van Caster, A. Skyschally, K. Boengler, P. Gres, R. Schulz, and G. Heusch Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs Cardiovasc Res, January 1, 2010; 85(1): 110 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Iliodromitis, J. M. Downey, G. Heusch, and D. T. Kremastinos What Is the Optimal Postconditioning Algorithm? Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2009; 14(4): 269 - 273. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Tamareille, N. Ghaboura, F. Treguer, D. Khachman, A. Croue, D. Henrion, A. Furber, and F. Prunier Myocardial reperfusion injury management: erythropoietin compared with postconditioning Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2035 - H2043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Prasad, G. W. Stone, D. R. Holmes, and B. Gersh Reperfusion Injury, Microvascular Dysfunction, and Cardioprotection: The "Dark Side" of Reperfusion Circulation, November 24, 2009; 120(21): 2105 - 2112. [Full Text] [PDF]
|
|
|
|
 |
|
 O. C. Manintveld, M. t. L. Hekkert, N. T. van der Ploeg, P. D. Verdouw, and D. J. Duncker Interaction Between Pre- and Postconditioning in the In Vivo Rat Heart Experimental Biology and Medicine, November 1, 2009; 234(11): 1345 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lacerda, S. Somers, L. H. Opie, and S. Lecour Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway Cardiovasc Res, November 1, 2009; 84(2): 201 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Heusch No RISK, no ... cardioprotection? A critical perspective Cardiovasc Res, November 1, 2009; 84(2): 173 - 175. [Full Text] [PDF]
|
|
|
|
|
|
G. Heusch and R. Schulz Neglect of the coronary circulation: some critical remarks on problems in the translation of cardioprotection Cardiovasc Res, October 1, 2009; 84(1): 11 - 14. [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido, A. Tedgui, S. D. Kristensen, G. Pasterkamp, H. Schunkert, M. Wehling, P. G. Steg, W. Eisert, F. Rademakers, B. Casadei, et al. Identifying needs and opportunities for advancing translational research in cardiovascular disease Cardiovasc Res, August 1, 2009; 83(3): 425 - 435. [Full Text] [PDF]
|
|
|
|
|
|
K. Boengler, R. Schulz, and G. Heusch Loss of cardioprotection with ageing Cardiovasc Res, July 15, 2009; 83(2): 247 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gomez, B. Li, N. Mewton, I. Sanchez, C. Piot, M. Elbaz, and M. Ovize Inhibition of mitochondrial permeability transition pore opening: translation to patients Cardiovasc Res, July 15, 2009; 83(2): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Granfeldt, D. J. Lefer, and J. Vinten-Johansen Protective ischaemia in patients: preconditioning and postconditioning Cardiovasc Res, July 15, 2009; 83(2): 234 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, M. Ruiz-Meana, and H. M. Piper Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues Cardiovasc Res, July 15, 2009; 83(2): 165 - 168. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Krieg, Y. Liu, T. Rutz, C. Methner, X.-M. Yang, T. Dost, S. B. Felix, J.-P. Stasch, M. V. Cohen, and J. M. Downey BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts Eur. Heart J., July 1, 2009; 30(13): 1607 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Juhaszova, D. B. Zorov, Y. Yaniv, H. B. Nuss, S. Wang, and S. J. Sollott Role of Glycogen Synthase Kinase-3{beta} in Cardioprotection Circ. Res., June 5, 2009; 104(11): 1240 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Peart and J. P. Headrick Clinical cardioprotection and the value of conditioning responses Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1705 - H1720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Abdellaoui, G. Rioufol, and G. Finet Letter by Abdellaoui et al Regarding Article, "Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention" Circulation, January 27, 2009; 119(3): e19 - e19. [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Katare, M. Ando, Y. Kakinuma, M. Arikawa, T. Handa, F. Yamasaki, and T. Sato Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): 223 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Li, R. Chen, R. Huang, and W. Luo Clinical benefit of cardiac ischemic postconditioning in corrections of tetralogy of Fallot Interactive CardioVascular and Thoracic Surgery, January 1, 2009; 8(1): 17 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, I. Barba, V. Hernando, and D. Garcia-Dorado Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium Cardiovasc Res, January 1, 2009; 81(1): 116 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ishii, T. Amano, T. Matsubara, and T. Murohara Pharmacological Intervention for Prevention of Left Ventricular Remodeling and Improving Prognosis in Myocardial Infarction Circulation, December 16, 2008; 118(25): 2710 - 2718. [Full Text] [PDF]
|
|
|
|
|
|
P. G. Steg and G. Ducrocq Devices to protect against embolization during primary angioplasty for ST-segment elevation myocardial infarction: the good, the bad and the ugly Eur. Heart J., December 2, 2008; 29(24): 2953 - 2954. [Full Text] [PDF]
|
|
|
|
|
|
G. Heusch, K. Boengler, and R. Schulz Cardioprotection: Nitric Oxide, Protein Kinases, and Mitochondria Circulation, November 4, 2008; 118(19): 1915 - 1919. [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. G. Edwards, M. Y. White, and S. J. Cordwell The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery Mol. Cell. Proteomics, October 1, 2008; 7(10): 1824 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Bouhidel, S. Pons, R. Souktani, R. Zini, A. Berdeaux, and B. Ghaleh Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1580 - H1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xi, A. Das, Z.-Q. Zhao, V. F. Merino, M. Bader, and R. C. Kukreja Loss of Myocardial Ischemic Postconditioning in Adenosine A1 and Bradykinin B2 Receptors Gene Knockout Mice Circulation, September 30, 2008; 118(14_suppl_1): S32 - S37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. C. Yong, S. W. Lee, C. S. Foo, K. L. Neo, X. Chen, and J.-S. Bian Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1330 - H1340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. McAllister, H. Ashrafpour, N. Cahoon, N. Huang, M. A. Moses, P. C. Neligan, C. R. Forrest, J. E. Lipa, and C. Y. Pang Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R681 - R689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Xing, H. Chen, M. Zhang, D. Zhao, R. Jiang, X. Liu, and S. Zhang Ischemic Postconditioning Inhibits Apoptosis After Focal Cerebral Ischemia/Reperfusion Injury in the Rat Stroke, August 1, 2008; 39(8): 2362 - 2369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishino, I. G. Webb, S. M. Davidson, A. I. Ahmed, J. E. Clark, S. Jacquet, A. M. Shah, T. Miura, D. M. Yellon, M. Avkiran, et al. Glycogen Synthase Kinase-3 Inactivation Is Not Required for Ischemic Preconditioning or Postconditioning in the Mouse Circ. Res., August 1, 2008; 103(3): 307 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Hausenloy and D. M. Yellon Remote ischaemic preconditioning: underlying mechanisms and clinical application Cardiovasc Res, August 1, 2008; 79(3): 377 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Piot, P. Croisille, P. Staat, H. Thibault, G. Rioufol, N. Mewton, R. Elbelghiti, T. T. Cung, E. Bonnefoy, D. Angoulvant, et al. Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction N. Engl. J. Med., July 31, 2008; 359(5): 473 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Jin, J. S. Karliner, and D. A. Vessey Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation Cardiovasc Res, July 1, 2008; 79(1): 134 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dow, A. Bhandari, and R. A. Kloner Ischemic Postconditioning's Benefit on Reperfusion Ventricular Arrhythmias Is Maintained in the Senescent Heart Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2008; 13(2): 141 - 148. [Abstract] [PDF]
|
|
|
|
|
|
L. Gomez, M. Paillard, H. Thibault, G. Derumeaux, and M. Ovize Inhibition of GSK3{beta} by Postconditioning Is Required to Prevent Opening of the Mitochondrial Permeability Transition Pore During Reperfusion Circulation, May 27, 2008; 117(21): 2761 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Przyklenk, M. Maynard, C. E. Darling, and P. Whittaker Aging Mouse Hearts Are Refractory to Infarct Size Reduction With Post-Conditioning J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1393 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Jugdutt and A. Jelani Aging and Defective Healing, Adverse Remodeling, and Blunted Post-Conditioning in the Reperfused Wounded Heart J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1399 - 1403. [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, I. Barba, V. Hernando, A. Abellan, M. Ruiz-Meana, A. Rodriguez-Sinovas, and D. Garcia-Dorado Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage Cardiovasc Res, March 1, 2008; 77(4): 782 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thibault, C. Piot, P. Staat, L. Bontemps, C. Sportouch, G. Rioufol, T. T. Cung, E. Bonnefoy, D. Angoulvant, J.-F. Aupetit, et al. Long-Term Benefit of Postconditioning Circulation, February 26, 2008; 117(8): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Luo, B. Li, R. Chen, R. Huang, and G. Lin Effect of ischemic postconditioning in adult valve replacement Eur. J. Cardiothorac. Surg., February 1, 2008; 33(2): 203 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Chen, S. Moghaddas, C. L. Hoppel, and E. J. Lesnefsky Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria Am J Physiol Cell Physiol, February 1, 2008; 294(2): C460 - C466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Gustafsson and R. A. Gottlieb Heart mitochondria: gates of life and death Cardiovasc Res, January 15, 2008; 77(2): 334 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Piper, Y. Abdallah, S. Kasseckert, and K.-D. Schluter Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury Cardiovasc Res, January 15, 2008; 77(2): 234 - 236. [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Mentzer Jr, M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2008; 3(2008): 443 - 464. [Full Text]
|
|
|
|
|
|
S. L. Hale, A. Mehra, J. Leeka, and R. A. Kloner Postconditioning fails to improve no reflow or alter infarct size in an open-chest rabbit model of myocardial ischemia-reperfusion Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H421 - H425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferdinandy, R. Schulz, and G. F. Baxter Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning Pharmacol. Rev., December 1, 2007; 59(4): 418 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vinten-Johansen, Z.-Q. Zhao, R. Jiang, A. J. Zatta, and G. P. Dobson Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury J Appl Physiol, October 1, 2007; 103(4): 1441 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Morrison, X. L. Tan, C. Ledent, S. J. Mustafa, and P. A. Hofmann Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2523 - H2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Downey and M. V. Cohen Bypassing Big Pharma Circulation, September 18, 2007; 116(12): 1344 - 1345. [Full Text] [PDF]
|
|
|
|
|
|
S. P. Loukogeorgakis, R. Williams, A. T. Panagiotidou, S. K. Kolvekar, A. Donald, T. J. Cole, D. M. Yellon, J. E. Deanfield, and R. J. MacAllister Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a KATP Channel Dependent Mechanism Circulation, September 18, 2007; 116(12): 1386 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Yellon and D. J. Hausenloy Myocardial Reperfusion Injury N. Engl. J. Med., September 13, 2007; 357(11): 1121 - 1135. [Full Text] [PDF]
|
|
|
|
 |
|
 Hardev Ramandeep Singh Girn, S. Ahilathirunayagam, A. I. D. Mavor, and S. Homer-Vanniasinkam Reperfusion Syndrome: Cellular Mechanisms of Microvascular Dysfunction and Potential Therapeutic Strategies Vascular and Endovascular Surgery, September 1, 2007; 41(4): 277 - 293. [Abstract] [PDF]
|
|
|
|
|
|
K. Forster, A. Kuno, N. Solenkova, S. B. Felix, and T. Krieg The {delta}-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1604 - H1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Taki, T. Higuchi, A. Kawashima, M. Fukuoka, D. Kayano, J. F. Tait, I. Matsunari, K. Nakajima, S. Kinuya, and H. W. Strauss Effect of Postconditioning on Myocardial 99mTc-Annexin-V Uptake: Comparison with Ischemic Preconditioning and Caspase Inhibitor Treatment J. Nucl. Med., August 1, 2007; 48(8): 1301 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Deyhimy, N. W. Fleming, I. G. Brodkin, and H. Liu Anesthetic Preconditioning Combined with Postconditioning Offers No Additional Benefit Over Preconditioning or Postconditioning Alone Anesth. Analg., August 1, 2007; 105(2): 316 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Lim, S. M. Davidson, D. J. Hausenloy, and D. M. Yellon Preconditioning and postconditioning: The essential role of the mitochondrial permeability transition pore Cardiovasc Res, August 1, 2007; 75(3): 530 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thibault, L. Gomez, E. Donal, G. Pontier, M. Scherrer-Crosbie, M. Ovize, and G. Derumeaux Acute myocardial infarction in mice: assessment of transmurality by strain rate imaging Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H496 - H502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Penna, D. Mancardi, R. Rastaldo, G. Losano, and P. Pagliaro Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling Cardiovasc Res, July 1, 2007; 75(1): 168 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-X. Jin, J.-J. Zhou, M. Xin, D.-R. Peng, X.-M. Wang, S.-H. Bi, X.-F. Wei, and D.-H. Yi Postconditioning the Human Heart with Adenosine in Heart Valve Replacement Surgery Ann. Thorac. Surg., June 1, 2007; 83(6): 2066 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J Hausenloy and D. M Yellon The evolving story of "conditioning" to protect against acute myocardial ischaemia-reperfusion injury Heart, June 1, 2007; 93(6): 649 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Andreka, M. Vertesaljai, G. Szantho, G. Font, Z. Piroth, G. Fontos, E. D Juhasz, L. Szekely, Z. Szelid, M. S Turner, et al. Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs Heart, June 1, 2007; 93(6): 749 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Dirksen, G. J. Laarman, M. L. Simoons, and D. J.G.M. Duncker Reperfusion injury in humans: A review of clinical trials on reperfusion injury inhibitory strategies Cardiovasc Res, June 1, 2007; 74(3): 343 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Luo, B. Li, G. Lin, and R. Huang Postconditioning in cardiac surgery for tetralogy of Fallot J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1373 - 1374. [Full Text] [PDF]
|
|
|
|
|
|
W. Y. Vanagt, R. N. Cornelussen, T. C. Baynham, A. Van Hunnik, Q. P. Poulina, F. Babiker, J. Spinelli, T. Delhaas, and F. W. Prinzen Pacing-Induced Dyssynchrony During Early Reperfusion Reduces Infarct Size J. Am. Coll. Cardiol., May 1, 2007; 49(17): 1813 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Cohen, X.-M. Yang, and J. M. Downey The pH Hypothesis of Postconditioning: Staccato Reperfusion Reintroduces Oxygen and Perpetuates Myocardial Acidosis Circulation, April 10, 2007; 115(14): 1895 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Shi, X. Jiang, T. Kazui, N. Washiyama, K. Yamashita, H. Terada, and A. H. M. Bashar Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 942 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lerman, D. R. Holmes, J. Herrmann, and B. J. Gersh Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both? Eur. Heart J., April 1, 2007; 28(7): 788 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Schmidt, M. Smerup, I. E. Konstantinov, M. Shimizu, J. Li, M. Cheung, P. A. White, S. B. Kristiansen, K. Sorensen, V. Dzavik, et al. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1883 - H1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Opie and H. Selker Letter by Opie and Selker Regarding Article, "Reperfusion Starts in the Ambulance" Circulation, December 12, 2006; 114(24): e640 - e640. [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Tang, H. Sato, S. Tiwari, B. Dawn, Q. Bi, Q. Li, G. Shirk, and R. Bolli Cardioprotection by postconditioning in conscious rats is limited to coronary occlusions <45 min Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2308 - H2317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhu, J. Feng, E. Lucchinetti, G. Fischer, L. Xu, T. Pedrazzini, M. C. Schaub, and M. Zaugg Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway Cardiovasc Res, October 1, 2006; 72(1): 152 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Couvreur, L. Lucats, R. Tissier, A. Bize, A. Berdeaux, and B. Ghaleh Differential effects of postconditioning on myocardial stunning and infarction: a study in conscious dogs and anesthetized rabbits Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1345 - H1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, D. A. Neff, J. G. Krolikowski, D. Weihrauch, M. Bienengraeber, D. C. Warltier, J. R. Kersten, and P. S. Pagel The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits. Anesth. Analg., May 1, 2006; 102(5): 1355 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, J. Vinten-Johansen, and H. M. Piper Bringing preconditioning and postconditioning into focus Cardiovasc Res, May 1, 2006; 70(2): 167 - 169. [Full Text] [PDF]
|
|
|
|
|
|
D. Ramzy, V. Rao, and R. D. Weisel Clinical applicability of preconditioning and postconditioning: The cardiothoracic surgeons's view Cardiovasc Res, May 1, 2006; 70(2): 174 - 180. [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Zhao and J. Vinten-Johansen Postconditioning: Reduction of reperfusion-induced injury Cardiovasc Res, May 1, 2006; 70(2): 200 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Hausenloy and D. M. Yellon Survival kinases in ischemic preconditioning and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 240 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Gateau-Roesch, L. Argaud, and M. Ovize Mitochondrial permeability transition pore and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 264 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner and S. H. Rezkalla Preconditioning, postconditioning and their application to clinical cardiology Cardiovasc Res, May 1, 2006; 70(2): 297 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Philipp, X.-M. Yang, L. Cui, A. M. Davis, J. M. Downey, and M. V. Cohen Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade Cardiovasc Res, May 1, 2006; 70(2): 308 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Laskey, P. Staat, G. Rioufol, E. Bonnefoy, G. Finet, X. Andre-Fouet, M. Ovize, C. Piot, T. T. Cung, Y. Cottin, et al. Letter Regarding Article by Staat et al, "Postconditioning the Human Heart" Circulation, March 28, 2006; 113(12): e665 - e665. [Full Text] [PDF]
|
|