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(Circulation. 2007;115:50-58.)
© 2007 American Heart Association, Inc.

Health Services and Outcomes Research

Atherosclerotic Renovascular Disease in Older US Patients Starting Dialysis, 1996 to 2001

Haifeng Guo, MS; Philip A. Kalra, MD, FRCP; David T. Gilbertson, PhD; Jiannong Liu, PhD; Shu-Cheng Chen, MS; Allan J. Collins, MD; Robert N. Foley, MB

From the United States Renal Data System Coordinating Center (H.G., D.T.G., J.L., S.-C.C., A.J.C., R.N.F.), Minneapolis, Minn; Department of Renal Medicine (P.A.K.), Hope Hospital, Salford, United Kingdom; and Department of Medicine (A.J.C., R.N.F.), University of Minnesota, Minneapolis.

Correspondence to Robert N. Foley, MB, United States Renal Data System, 914 S 8th St, Suite S-253, Minneapolis, MN 55404. E-mail RFoley{at}usrds.org

Received May 3, 2006; accepted October 31, 2006.

Background— Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined.

Methods and Results— United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146 973). Medicare claims in the preceding 2 years were used to identify ARVD and revascularization procedures. Prior ARVD rose from 7.1% to 11.2% between 1996 and 2001 (adjusted odds ratio [AOR], 1.68). Other associations included hypertensive end-stage renal disease (ESRD; AOR, 2.21), ESRD network (AOR, 0.44 in network 17 versus 1.00 in network 1), peripheral vascular disease (AOR, 1.65), black race (AOR, 0.44), urologic cause of ESRD (AOR, 0.57), age >85 years (AOR, 0.58), substance dependency (AOR, 0.62), and inability to ambulate or transfer (AOR, 0.67). The proportion of ARVD patients undergoing revascularization rose from 14.6% to 16.7% between 1996 and 2001 (AOR, 1.27). Other associations included hypertension (AOR, 2.10), ESRD network (AOR, 2.07 for network 13 versus 1.00 in network 1), age >85 years (AOR, 0.53), and black race (AOR, 0.54). The rise in ARVD was not reflected in the proportion of patients with renovascular disease listed as cause of ESRD on the Medical Evidence Report at dialysis inception (5.5% in 1996, 5.0% in 2001).

Conclusions— ARVD diagnoses have become more common in older patients beginning dialysis therapy. The association of demographic factors including age, race, and geographic residence with utilization patterns suggests possible barriers to care.

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CLINICAL PERSPECTIVE

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