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(Circulation. 2007;115:3213-3223.)
© 2007 American Heart Association, Inc.

Basic Science for Clinicians

Diabetic Cardiomyopathy Revisited

Sihem Boudina, PhD; E. Dale Abel, MBBS, DPhil

From the Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City.

Correspondence to E. Dale Abel, Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, 15 N 2030 East, Bldg 533, Room 3410B, Salt Lake City, UT 84112. E-mail dale.abel{at}hmbg.utah.edu

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.

Key Words: diabetes mellitus • fatty acids • heart failure • metabolism • obesity

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