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(Circulation. 1956;13:515.)
© 1956 American Heart Association, Inc.

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Fluorescent Patterns of Intracutaneous Wheals in Normal and Edematous Extremities

RAY W. GIFFORD JR. M.D.¹; JOHN H. WINDESHEIM M.D.¹; J. EARLE ESTES JR. M.D.¹; GRACE M. ROTH PH.D.¹

¹ From the Section of Medicine and the Section of Physiology, Mayo Clinic; the Mayo Foundation, a part of the Graduate School of the University of Minnesota, Rochester, Minn.

Intradermal injection of a fluorescent dye (riboflavin) and ultraviolet light were used to demonstrate cutaneous lymphatic capillaries. The extremities of a control group and the nonedematous extremities of patients with arteriosclerosis obliterans were studied together with edematous extremities of patients with lymphedema, acute thrombophlebitis, chronic venous insufficiency and various other conditions.

The lymphatic capillaries showed up more extensively after a higher percentage of injections into edematous extremities of patients with lymphedema than after injections into the other extremities. On the other edematous extremities except in the cases of nephrotic syndrome and on the normal extremities, either no lymph capillaries or only a few were visible after most of the injections.