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(Circulation. 1956;13:586.)
© 1956 American Heart Association, Inc.

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Hemolytic Syndrome Following the Insertion of a Lucite Ball Valve Prosthesis into the Cardiovascular System

FREDERICK STOHLMAN JR. M.D.¹; STANLEY J. SARNOFF M.D.¹; ROBERT B. CASE M.D.¹; ARTHUR T. NESS PH.D.¹

¹ From the Laboratory of Pathology and Histochemistry of the National Institute of Arthritis and Metabolic Diseases and the Laboratory of Cardiovascular Hemodynamics, National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md.

Permanent bypass of the aortic valve was accomplished in the dog by placing a lucite conduit containing a Hufnagel valve between the left ventricular apex and thoracic aorta. Red cell destruction was produced by the valve in this position and was accompanied by hemoglobinemia, hemoglobinuria, anemia, reticulocytosis and renal hemosiderosis. Red cell survival, as determined with Cr⁵¹, was markedly shortened.

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