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(Circulation. 1956;14:60.)
© 1956 American Heart Association, Inc.

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The Relation of Cardiovascular Phenomena to Metabolic Changes in a Patient with Chronic Hypokalemia

EDWARD J. HUTH M.D.¹ RUSSELL D. SQUIRES M.D.¹

¹ From the Chemical Section of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa.

Cardiovascular phenomena were studied and correlated with metabolic data in an adult male with chronic hypokalemia. The appearance and disappearance of postural hypotension, the changes in heart rate, the S-T segment shifts, and the U-wave amplitudes correlated well with the changing serum potassium level during experimental acute potassium depletion. QRS and T-wave changes could not be correlated with metabolic data. Comparison with the cardiovascular manifestations of experimental potassium depletion in normal subjects suggested that this patient had a chronic potassium depletion of at least 300 mEq.