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(Circulation. 1957;15:405.)
© 1957 American Heart Association, Inc.

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Assay of Anti-Anginal Agents

I. A Curve Analysis with Multiple Control Periods

SEYMOUR L. COLE M.D.¹; HARRY KAYE M.D.¹; GEORGE C. GRIFFITH M.D.¹

¹ From the Department of Medicine (Cardiology), University of Southern California School of Medicine, and the Los Angeles County Hospital, Los Angeles, Calif.

The measure of an anti-anginal agent is its ability to decrease chest pain. Because of the subjective character of pain, extreme care is necessary in choosing patients upon whom anti-anginal medication is to be tested. We have used the double-blind technic and an initial control period to neutralize the many extraneous mental and physical factors, such as bias or the patient-physician relationship itself, that might interfere with an accurate appraisal. This study shows, in addition, that proper evaluation of an anti-anginal agent requires that its effect be measured against multiple control periods without medication throughout the various phases of angina pectoris.

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