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Circulation. 1957;15:547-558

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(Circulation. 1957;15:547.)
© 1957 American Heart Association, Inc.

Ventricular Arrhythmias after Intravenous Sodium Lactate in Heart Block

JOHN F. MURRAY M.D.1 S. H. BOYER IV M.D.1

1 From the Department of Medicine, State University of New York College of Medicine at New York City and Kings County Hospital, Brooklyn, N. Y.

Molar sodium lactate has been described as a safe and effective agent in the treatment of bradycardia accompanying complete heart block. However, in 12 patients with heart block, hypertonic lactate infusions produced ventricular tachycardia in 6 and an increased idioventricular rate in only 4. Isopropylnorepinephrine was more effective and without such hazard. The effects of alkalosis from molar lactate, 5 per cent sodium bicarbonate, and hyperventilation are compared. Of these 3, lactate was productive of the greatest ventricular acceleration.






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