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(Circulation. 1957;16:723.)
© 1957 American Heart Association, Inc.

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Effect of Sitosterol on the Concentration of Serum Lipids in Patients with Coronary Atherosclerosis

FLETCHER P. RILEY M.D.¹ ALFRED STEINER M.D.¹

¹ From the Research Service, First (Columbia University) Division, Goldwater Memorial Hospital and the Department of Medicine, College of Physicians and Sturgeons, Columbia University, New York, N. Y.

The oral administration of large amounts of sitosterol to patients with coronary atherosclerosis has resulted in statistically significant decrease in serum cholesterol in one half of the trial periods. However, because of the fluctuation of the serum cholesterol that occurs in patients with coronary atherosclerosis, further study will be necessary to demonstrate that the decrease in serum cholesterol coincident with sitosterol administration is not due to the lability of the serum lipids in this group of individuals.

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