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(Circulation. 1958;17:208.)
© 1958 American Heart Association, Inc.

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Interrelationship of Drugs Influencing Arterial Pressure in Man

WALTER REDISCH M.D.¹; FRANCISCO F. TANGCO M.D.¹; ARTHUR J. LEWIS M.D.¹; MARIA AURORA ANTONIO M.D.¹; KURT DECRINIS M.D.¹; J. MURRAY STEELE M.D.¹; Dorothy Andrews ¹; Stephen Menkes ¹

¹ From the Research Service (Third New York University) Medical Division, Goldwater Memorial Hospital, and the Department of Medicine, New York University College of Medicine, New York, N. Y.

Comparison of hemodynamic changes (cardiac output, renal plasma flow, and extremity blood flow) observed during reserpine-induced hypotension with those occurring during pentolinium-induced hypotension suggests better adaptation following reserpine. This difference is believed to be related to the gradation of onset of hypotension. It was found that reserpine-induced hypotension is potentiated by norepinephrine, and pentolinium-induced hypotension by serotonin. Pretreatment with the hypotensive agent increased the pressor response to norepinephrine and serotonin respectively, if the pressor substance was administered before the onset of hypotension.

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