This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by WAINFELD, B. Articles by SCHWARTZ, I. R. Search for Related Content PubMed PubMed Citation Articles by WAINFELD, B. Articles by SCHWARTZ, I. R.

(Circulation. 1958;17:918.)
© 1958 American Heart Association, Inc.

---

Effectiveness of an Oral, Nonmercurial Diuretic

Clinical Trial with Thirty-Five Patients

BENJAMIN WAINFELD M.D.¹; JACOB J. YARVIS M.D.¹; I. RICHARD SCHWARTZ M.D.¹

¹ From the Medical Clinic, Out-Patient Department, Kings County Hospital Center, Brooklyn, N. Y.

In a previous trial of aminometramid on 30 patients with peripheral edema, 19 became refractory to the drug. These 19 patients and another group of 16 with peripheral edema or ascites were placed on another nonmercurial diuretic aminoisometradine, which had shown promise in previous studies in animals and man. This group of 35 patients who had previously required frequent injections of mercurial diuretics were treated with the new diuretic for at least 8 months. Conclusions of this study are presented.