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(Circulation. 1958;18:1139.)
© 1958 American Heart Association, Inc.

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The Determination of Cardiac Output by the Dilution Method without Arterial Sampling

I. Analytical Concepts

WILLIAM J. MACINTYRE PH.D.¹; WALTER H. PRITCHARD M.D.¹; THOMHAS W. MOIR M.D.¹

¹ From the Departments of Medicine and Radiology, University Hospitals and Western Reserve University, Cleveland, Ohio.

The selection of an external site for a radioisotope determination of cardiac output is discussed with respect to satisfying the analytical conditions of the Stewart-Hamilton dilution equation. Examples of both single-chamber and multichamber recording are illustrated, along with a discussion of the difficulties of curve calibration and extrapolation from multiple sites. The development of a method independent of critical placement or patient variability is described.