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(Circulation. 1958;18:1167.)
© 1958 American Heart Association, Inc.

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Relation between Structural Changes in the Small Pulmonary Arteries and the Immediate Reversibility of Pulmonary Hypertension Following Closure of Ventricular and Atrial Septal Defects

DONALD HEATH M.D.¹; H. FREDERIC HELMHOLZ JR. M.D.¹; HOWARD B. BURCHELL M.D.¹; JAMES W. DUSHANE M.D.¹; JOHN W. KIRKLIN M.D.¹; JESSE E. EDWARDS M.D.¹

¹ From the Mayo Foundation and the Mayo Clinic, Rochester, Minn. The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.

The relative importance of organic changes and vasoconstrictive influences in the production of increased pulmonary vascular resistance in congenital heart disease is problematic. With use of a grading system previously described, a study was made of the relation between each of the grades of hypertensive pulmonary vascular disease associated with ventricular or atrial septal defects and the change of pulmonary artery blood pressure immediately following closure of the abnormal communications. The immediate reversibility of the pulmonary hypertension varies inversely with the severity of the structural changes.

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