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(Circulation. 1959;19:242.)
© 1959 American Heart Association, Inc.

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Familial Pseudoxanthoma Elasticum and Valvular Heart Disease

JAY D. COFFMAN M.D.¹ SHELDON C. SOMMERS M.D.¹

¹ From the Departments of Medicine and Pathology, Boston University School of Medicine, and Massachusetts Memorial Hospitals, Boston, Mass.

The clinical and pathologic findings are presented of a patient with pseudoxanthoma elasticum leading to fatal valvular heart disease. The literature concerning the involvement of the heart by this disease is reviewed and reveals that valvular heart disease has not been described as a clinical problem heretofore. The occurrence of the condition in the relatives of the patient is described.