This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by WEINBERG, S. L. Articles by MURPHY, J. P. Search for Related Content PubMed PubMed Citation Articles by WEINBERG, S. L. Articles by MURPHY, J. P. Pubmed/NCBI databases Substance via MeSH

(Circulation. 1959;19:590.)
© 1959 American Heart Association, Inc.

---

Normal Response Curve to Exercise of Relative Cardiac Output Measured with Radioiodinated Serum Albumin

SYLVAN L. WEINBERG M.D.¹; G. RICHARD GROVE PH.D.¹; ROBERT E. ZIPF M.D.¹; DAVID C. DANIELS B.S.¹; JAMES P. MURPHY B.S.¹

¹ From the Department of Research, Miami Valley Hospital, Dayton, Ohio.

A simple, relatively precise, and clinically applicable indirect method of determining relative cardiac output is presented. The principle involved is a modification of the dye-dilution principle and is performed by external monitoring of intravenously injected radioiodinated serum albumin combined with a standard detecting and recording device. This procedure was performed serially before and after a standard Master test, and the results in 19 healthy individuals describe a relative cardiac output exercise response curve for normal individuals. The utilization of cardiac output in the manner presented may add another clinical measurement of cardiac function.