This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by BEST, M. M. Articles by COE, W. S. Search for Related Content PubMed PubMed Citation Articles by BEST, M. M. Articles by COE, W. S.

(Circulation. 1950;2:344.)
© 1950 American Heart Association, Inc.

---

Effect of Khellin on Coronary Artery Insufficiency as Evaluated by Electrocardiographic Tests

MAURICE M. BEST M.D.¹ WALTER S. COE M.D.¹

¹ From the Institute for Medical Research and Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.

The effectiveness of khellin in 9 patients with angina pectoris was evaluated electrocardiographically by means of the exercise tolerance, anoxemia and ergonovine tests. Normalization occurred in the majority of the previously abnormal tests following khellin therapy. A beneficial effect was noted on symptoms accompanied by a reduction in nitroglycerin requirement. Mild toxicity, as a result of khellin therapy, was observed in 3 cases.