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(Circulation. 1950;2:505.)
© 1950 American Heart Association, Inc.

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The Nature of Pressor Substances in Pheochromocytomas

D. M. PITCAIRN M.D.¹ W. B. YOUMANS M.D.¹

¹ From the Department of Physiology, University of Oregon Medical School, Portland, Oregon.

The actions of aqueous extracts of two pheochromocytomas are compared before and after the administration of the adrenergic blocking agent, Dibenamine. One tumor contained predominantly a substance which, like norepinephrine, had pressor actions after Dibenamine. The other tumor contained chiefly an epinephrine-like substance. The significance of the presence of norepinephrine in pheochromocytomas and its role in epinephrine metabolism are discussed.

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